Gene
ctnnb1
- ID
- ZDB-GENE-980526-362
- Name
- catenin (cadherin-associated protein), beta 1
- Symbol
- ctnnb1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Enables cadherin binding activity. Involved in canonical Wnt signaling pathway. Acts upstream of or within several processes, including determination of dorsal/ventral asymmetry; ectoderm development; and glomerular filtration. Located in several cellular components, including intercalated disc; microvillus; and zonula adherens. Part of catenin complex. Is expressed in several structures, including EVL; adaxial cell; brain; germ ring; and gonad. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant intellectual developmental disorder 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple). Orthologous to human CTNNB1 (catenin beta 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 47 figures from 40 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56048 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| hg101 | Allele with one deletion | Unknown | Unknown | CRISPR | |
| la019872Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa11589 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-ctnnb1 | (4) | |
| CRISPR2-ctnnb1 | (2) | |
| CRISPR3-ctnnb1 | Rosello et al., 2021 | |
| MO1-ctnnb1 | N/A | (11) |
| MO2-ctnnb1 | N/A | (8) |
| MO3-ctnnb1 | N/A | (3) |
| MO4-ctnnb1 | N/A | Bellipanni et al., 2006 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 19 | Alliance | Neurodevelopmental disorder with spastic diplegia and visual defects | 615075 |
| colorectal cancer | Alliance | Colorectal cancer, somatic | 114500 |
| exudative vitreoretinopathy 7 | Alliance | Exudative vitreoretinopathy 7 | 617572 |
| hepatocellular carcinoma | Alliance | Hepatocellular carcinoma, somatic | 114550 |
| medulloblastoma | Alliance | Medulloblastoma, somatic | 155255 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Armadillo | Armadillo-like helical | Armadillo-type fold | Beta-catenin |
|---|---|---|---|---|---|
|
UniProtKB:A0A5H1ZRJ2
|
789 | ||||
|
UniProtKB:F1QGH7
|
780 | ||||
|
UniProtKB:A0A8M6Z121
|
731 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ctnnb1-201
(1)
|
Ensembl | 3,558 nt | ||
| mRNA |
ctnnb1-202
(1)
|
Ensembl | 2,419 nt |
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Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab3-ctnnb1 | monoclonal | IgG1 , k | Mouse |
|
Millipore
|
7 | |
| Ab2-ctnnb1 | polyclonal | Rabbit |
|
Sigma-Aldrich
|
30 | ||
| Ab1-ctnnb1 | monoclonal | IgG1 , k | Mouse |
|
Life Technologies (Invitrogen)
|
3 | |
| Ab2-ctnnb | monoclonal | IgG1 | Mouse |
|
BD Biosciences
|
33 |
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Plasmids
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(hsp70l:ca-ctnnb1) |
|
| 1 | Palsamy et al., 2023 | |
| Tg(UAS:cactnnb1-2A-mKate2,myl7:EGFP) |
| 1 | (2) | ||
| Tg(UAS:ctnnb1-RFP) |
|
| 1 | (3) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-49B13 | ZFIN Curated Data | |
| Contains | SNP | rs3728768 | ZFIN Curated Data | |
| Encodes | EST | fb73e10 | ZFIN Curated Data | |
| Encodes | EST | fi81c06 | ZFIN Curated Data | |
| Encodes | EST | fk25h01 | ||
| Encodes | EST | ibd2058 | ||
| Encodes | cDNA | MGC:56048 | ZFIN Curated Data | |
| Has Artifact | EST | fj58f01 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131059 (1) | 3375 nt | ||
| Genomic | GenBank:AL845513 (1) | 164117 nt | ||
| Polypeptide | UniProtKB:A0A5H1ZRJ2 (1) | 789 aa |
- Bell, J.M., Turner, E.M., Biesemeyer, C., Vanderbeck, M.M., Hendricks, R., McGraw, H.F. (2024) foxg1a is required for hair cell development and regeneration in the zebrafish lateral line. Biology Open. 13(9):
- Dennhag, N., Kahsay, A., Nissen, I., Nord, H., Chermenina, M., Liu, J., Arner, A., Liu, J.X., Backman, L.J., Remeseiro, S., von Hofsten, J., Pedrosa Domellöf, F. (2024) fhl2b mediates extraocular muscle protection in zebrafish models of muscular dystrophies and its ectopic expression ameliorates affected body muscles. Nature communications. 15:19501950
- Karimi, Z., Zarifkar, A., Mirzaei, E., Dianatpour, M., Dara, M., Aligholi, H. (2024) Therapeutic effects of nanosilibinin in valproic acid-zebrafish model of autism spectrum disorder: Focusing on Wnt signaling pathway and autism spectrum disorder-related cytokines. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 84(5):454-468
- Megerson, E., Kuehn, M., Leifer, B., Bell, J.M., Snyder, J.L., McGraw, H.F. (2023) Kremen1 regulates the regenerative capacity of support cells and mechanosensory hair cells in the zebrafish lateral line. iScience. 27:108678108678
- Palsamy, K., Chen, J.Y., Skaggs, K., Qadeer, Y., Connors, M., Cutler, N., Richmond, J., Kommidi, V., Poles, A., Affrunti, D., Powell, C., Goldman, D., Parent, J.M. (2023) Microglial depletion after brain injury prolongs inflammation and impairs brain repair, adult neurogenesis and pro-regenerative signaling. Glia. 71(11):2642-2663
- Tao, Z., Yang, D., Ni, R. (2023) Tmed10 deficiency results in impaired exocrine pancreatic differentiation in zebrafish larvae. Developmental Biology. 503:43-52
- Ulhaq, Z.S., Ogino, Y., Tse, W.K.F. (2023) FGF8 rescues motor deficits in zebrafish model of limb-girdle muscular dystrophy R18. Biochemical and Biophysical Research Communications. 652:768376-83
- Zhang, Z., Yang, C., Wang, Z., Guo, L., Xu, Y., Gao, C., Sun, Y., Zhang, Z., Peng, J., Hu, M., Jan Lo, L., Ma, Z., Chen, J. (2023) Wdr5-mediated H3K4me3 coordinately regulates cell differentiation, proliferation termination, and survival in digestive organogenesis. Cell death discovery. 9:227227
- Chen, X., Liu, F., Chen, K., Wang, Y., Yin, A., Kang, X., Yang, S., Zhao, H., Dong, S., Li, Y., Chen, J., Wu, Y. (2022) TFG mutation induces haploinsufficiency and drives axonal Charcot-Marie-Tooth disease by causing neurite degeneration. CNS neuroscience & therapeutics. 28(12):2076-2089
- Duan, X., Shi, Y., Zhao, S., Yao, L., Sheng, J., Liu, D. (2022) Foxc1a regulates zebrafish vascular integrity and brain vascular development through targeting amotl2a and ctnnb1. Microvascular Research. 143:104400
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