Gene

ctnnb1

ID

ZDB-GENE-980526-362

Name

catenin (cadherin-associated protein), beta 1

Symbol

ctnnb1 Nomenclature History

Previous Names

ctnnb (1)
id:ibd2058
wu:fb73e10 (1)
wu:fi81c06 (1)
wu:fk25h01

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Description

Exhibits cadherin binding activity. Involved in several processes, including determination of dorsal/ventral asymmetry; glomerular filtration; and positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification. Localizes to several cellular components, including catenin complex; intercalated disc; and zonula adherens. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant non-syndromic intellectual disability 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple). Is expressed in several structures, including EVL; adaxial cell; brain; germ ring; and gonad. Orthologous to human CTNNB1 (catenin beta 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

46 figures from 39 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56048 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 4 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ctnnb1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant intellectual developmental disorder 19	Alliance	Neurodevelopmental disorder with spastic diplegia and visual defects	615075
colorectal cancer	Alliance	Colorectal cancer, somatic	114500
exudative vitreoretinopathy 7	Alliance	Exudative vitreoretinopathy 7	617572
hepatocellular carcinoma	Alliance	Hepatocellular carcinoma, somatic	114550
medulloblastoma	Alliance	Medulloblastoma, somatic	155255
ovarian cancer	Alliance	Ovarian cancer, somatic	167000
pilomatrixoma	Alliance	Pilomatricoma, somatic	132600

Associated With ctnnb1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR013284	Beta-catenin
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold
Repeat	IPR000225	Armadillo

Domain Details Per Protein

Protein	Length	Armadillo	Armadillo-like helical	Armadillo-type fold	Beta-catenin
UniProtKB:A0A5H1ZRJ2 InterPro	789
UniProtKB:F1QGH7 InterPro PDB	780
UniProtKB:A0A8M6Z121 InterPro	731

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	ctnnb1-201 (1) Ensembl	Ensembl		3,558 nt	Select Tool
mRNA	ctnnb1-202 (1) Ensembl	Ensembl		2,419 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab3-ctnnb1	monoclonal	ctnnb1	IgG1 , k	Mouse	IHC WB	Millipore	7
Ab2-ctnnb1	polyclonal	ctnnb1		Rabbit	IHC WB	Sigma-Aldrich	29
Ab1-ctnnb1	monoclonal	ctnnb1	IgG1 , k	Mouse	IHC	Life Technologies (Invitrogen)	3
Ab2-ctnnb	monoclonal	ctnnb1	IgG1	Mouse	IHC WB	BD Biosciences	31

Plasmids

Addgene:M58 pPET28b-TEV-full-length zebrafish beta catenin

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations