Gene

ctnnb1

ID
ZDB-GENE-980526-362
Name
catenin (cadherin-associated protein), beta 1
Symbol
ctnnb1 Nomenclature History
Previous Names
  • ctnnb (1)
  • id:ibd2058
  • wu:fb73e10 (1)
  • wu:fi81c06 (1)
  • wu:fk25h01
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Exhibits cadherin binding activity. Involved in several processes, including determination of dorsal/ventral asymmetry; glomerular filtration; and positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification. Localizes to several cellular components, including catenin complex; intercalated disc; and zonula adherens. Is expressed in several structures, including EVL; adaxial cell; brain; germ ring; and gonad. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant non-syndromic intellectual disability 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); reproductive organ cancer (multiple); and urinary system cancer (multiple). Orthologous to human CTNNB1 (catenin beta 1).
Genome Resources
Note
None
Expression
All Expression Data
32 figures from 26 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ctnnb1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant non-syndromic intellectual disability 19 Alliance Neurodevelopmental disorder with spastic diplegia and visual defects 615075
colorectal cancer Alliance Colorectal cancer, somatic 114500
exudative vitreoretinopathy 7 Alliance Exudative vitreoretinopathy 7 617572
hepatocellular carcinoma Alliance Hepatocellular carcinoma, somatic 114550
medulloblastoma Alliance Medulloblastoma, somatic 155255
ovarian cancer Alliance Ovarian cancer, somatic 167000
pilomatrixoma Alliance Pilomatricoma, somatic 132600
Associated With ctnnb1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR013284 Beta-catenin
Homologous_superfamily IPR011989 Armadillo-like helical
Homologous_superfamily IPR016024 Armadillo-type fold
Repeat IPR000225 Armadillo
Domain Details Per Protein
Protein Length Armadillo Armadillo-like helical Armadillo-type fold Beta-catenin
UniProtKB:A0A5H1ZRJ2 789
UniProtKB:F1QGH7 780
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab3-ctnnb1 monoclonal IgG1 , k Mouse
  • IHC
  • WB
Millipore
4
Ab2-ctnnb1 polyclonal Rabbit
  • IHC
  • WB
Sigma-Aldrich
25
Ab1-ctnnb1 monoclonal IgG1 , k Mouse
  • IHC
Life Technologies (Invitrogen)
2
Ab2-ctnnb monoclonal IgG1 Mouse
  • IHC
  • WB
BD Biosciences
27
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations