Gene
pdgfc
- ID
- ZDB-GENE-071217-2
- Name
- platelet derived growth factor c
- Symbol
- pdgfc Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable platelet-derived growth factor receptor binding activity. Predicted to be involved in several processes, including platelet-derived growth factor receptor signaling pathway; positive regulation of cell migration; and positive regulation of intracellular signal transduction. Predicted to be located in extracellular region and membrane. Predicted to be active in extracellular space. Is expressed in mouth and otic vesicle. Orthologous to human PDGFC (platelet derived growth factor C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6350 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CUB domain | Cystine-knot cytokine | PDGF/VEGF domain | Spermadhesin, CUB domain superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PBW1 | InterPro | 305 | ||||
| UniProtKB:A0A8N7TD29 | InterPro | 343 | ||||
| UniProtKB:A0AB32T266 | InterPro | 265 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-203D1 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-5I20 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-37G16 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_021472872 (1) | 5529 nt | ||
| Genomic | GenBank:CT009687 (1) | 189137 nt | ||
| Polypeptide | UniProtKB:A0A8N7TD29 (1) | 343 aa |
- Comparative Orthology
- Alliance
- Maugars, G., Nourizadeh-Lillabadi, R., Weltzien, F.A. (2020) New Insights Into the Evolutionary History of Melatonin Receptors in Vertebrates, With Particular Focus on Teleosts. Frontiers in endocrinology. 11:538196
- Tsata, V., Möllmert, S., Schweitzer, C., Kolb, J., Möckel, C., Böhm, B., Rosso, G., Lange, C., Lesche, M., Hammer, J., Kesavan, G., Beis, D., Guck, J., Brand, M., Wehner, D. (2020) A switch in pdgfrb+ cell-derived ECM composition prevents inhibitory scarring and promotes axon regeneration in the zebrafish spinal cord. Developmental Cell. 56(4):509-524.e9
- Mullapudi, S.T., Boezio, G.L.M., Rossi, A., Marass, M., Matsuoka, R.L., Matsuda, H., Helker, C.S.M., Yang, Y.H.C., Stainier, D.Y.R. (2019) Disruption of the pancreatic vasculature in zebrafish affects islet architecture and function. Development (Cambridge, England). 146(21):
- Bloomekatz, J., Singh, R., Prall, O.W., Dunn, A.C., Vaughan, M., Loo, C.S., Harvey, R.P., Yelon, D. (2017) Platelet-derived growth factor (PDGF) signaling directs cardiomyocyte movement toward the midline during heart tube assembly. eLIFE. 6
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Eberhart, J.K., He, X., Swartz, M.E., Yan, Y.L., Song, H., Boling, T.C., Kunerth, A.K., Walker, M.B., Kimmel, C.B., and Postlethwait, J.H. (2008) MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis. Nature Genetics. 40(3):290-298
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