Gene
gpr101
- ID
- ZDB-GENE-070914-1
- Name
- G protein-coupled receptor 101
- Symbol
- gpr101 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled receptor activity. Acts upstream of or within hypothalamus development and regulation of embryonic development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain. Human ortholog(s) of this gene implicated in growth hormone secreting pituitary adenoma 2. Orthologous to human GPR101 (G protein-coupled receptor 101).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Trivellin et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| growth hormone secreting pituitary adenoma 2 | Alliance | Pituitary adenoma 2, GH-secreting | 300943 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|
|
UniProtKB:E7FA10
|
437 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gpr101-201
(1)
|
Ensembl | 1,762 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(4xUAS:gpr101,cryaa:CFP) |
|
| 1 | Trivellin et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-127L15 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005173224 (1) | 2294 nt | ||
| Genomic | GenBank:AL929434 (1) | 178948 nt | ||
| Polypeptide | UniProtKB:E7FA10 (1) | 437 aa |
- Comparative Orthology
- Alliance
- Trivellin, G., Tirosh, A., Hernández-Ramírez, L.C., Gupta, T., Tsai-Morris, C.H., Faucz, F.R., Burgess, H.A., Feldman, B., Stratakis, C.A. (2020) The X-linked acrogigantism-associated gene gpr101 is a regulator of early embryonic development and growth in zebrafish. Molecular and Cellular Endocrinology. 520:111091
- Trivellin, G., Bjelobaba, I., Daly, A.F., Larco, D.O., Palmeira, L., Faucz, F.R., Thiry, A., Leal, L.F., Rostomyan, L., Quezado, M., Schernthaner-Reiter, M.H., Janjic, M., Villa, C., Wu, T.J., Stojilkovic, S.S., Albert, B., Feldman, B., Stratakis, C.A. (2016) Characterization of GPR101 transcripts structure and expression patterns. Journal of molecular endocrinology. 57(2):97-111
- Biswas, G., Kinoshita, S., Kono, T., Hikima, J.I., Sakai, M. (2015) Evolutionary evidence of tumor necrosis factor super family members in the Japanese pufferfish (Takifugu rubripes): Comprehensive genomic identification and expression analysis. Marine genomics. 22:25-36
- Keller, M.J., and Chitnis, A.B. (2007) Insights into the evolutionary history of the vertebrate zic3 locus from a teleost-specific zic6 gene in the zebrafish, Danio rerio. Development genes and evolution. 217(7):541-547
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