PUBLICATION
Insights into the evolutionary history of the vertebrate zic3 locus from a teleost-specific zic6 gene in the zebrafish, Danio rerio
- Authors
- Keller, M.J., and Chitnis, A.B.
- ID
- ZDB-PUB-070523-10
- Date
- 2007
- Source
- Development genes and evolution 217(7): 541-547 (Journal)
- Registered Authors
- Chitnis, Ajay
- Keywords
- Fishes, Zic, Evolution, Gene expression, Synteny
- MeSH Terms
-
- Zebrafish/genetics*
- Homeodomain Proteins/genetics*
- Repressor Proteins/genetics*
- Animals
- Models, Genetic
- Evolution, Molecular*
- Mice
- Gene Expression Regulation, Developmental
- Molecular Sequence Data
- Transcription Factors/genetics*
- Synteny
- Amino Acid Sequence
- Zebrafish Proteins/genetics*
- Sequence Alignment
- PubMed
- 17503076 Full text @ Dev. Genes Evol.
Citation
Keller, M.J., and Chitnis, A.B. (2007) Insights into the evolutionary history of the vertebrate zic3 locus from a teleost-specific zic6 gene in the zebrafish, Danio rerio. Development genes and evolution. 217(7):541-547.
Abstract
The Zic gene family of zinc-finger transcription factors includes five orthologues, zic1-5, that are common to the Euteleostian vertebrates (fish, frogs, birds, and mammals). The Zic genes have been implicated as regulators of a number of critical developmental processes, including neurulation, neuronal differentiation, neural crest specification, the establishment of left-right asymmetry, and regulation of cell proliferation. The different Zic genes encode proteins that are expressed in broadly overlapping spatial domains, have conserved DNA-binding domains that recognize a common motif, are capable of physical interactions, and can co-regulate one another's transcription. Thus, the transcriptional regulation of individual proteins and their effects on downstream targets must be assessed within the context of co-expression with other family members. We describe a novel gene, zic6, that is specific to the teleost fishes and lacks the lateral and rostral expression domains typical of the other Zic family members. We present evidence that zic6 is an ancestral locus arising by chromosomal duplication early in the Euteleostomi that was subsequently lost in the terrestrial vertebrates.
Genes / Markers
Expression
Phenotype
Mutations / Transgenics
Human Disease / Model
Sequence Targeting Reagents
Fish
Orthology
Engineered Foreign Genes
Mapping