Gene

mllt10

ID

ZDB-GENE-041114-176

Name

MLLT10 histone lysine methyltransferase DOT1L cofactor

Symbol

mllt10 Nomenclature History

Previous Names

id:ibd5120
wu:fe48f12
zgc:92208 (1)

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have metal ion binding activity. Involved in canonical Wnt signaling pathway; cellular homeostasis; and intestinal epithelial structure maintenance. Human ortholog(s) of this gene implicated in acute monocytic leukemia and acute myeloid leukemia. Is expressed in brain; hindbrain; intestine; and midbrain. Orthologous to human MLLT10 (MLLT10 histone lysine methyltransferase DOT1L cofactor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92208 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Mahmoudi et al., 2010
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mllt10 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
acute myeloid leukemia	Alliance	Leukemia, acute myeloid	601626

Associated With mllt10 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR019786	Zinc finger, PHD-type, conserved site
Domain	IPR001965	Zinc finger, PHD-type
Domain	IPR019787	Zinc finger, PHD-finger
Domain	IPR034732	Extended PHD (ePHD) domain
Domain	IPR049773	AF10-like, coiled-coil domain
Domain	IPR049775	AF-10, extended PHD finger
Domain	IPR049781	AF-10/AF-17, PHD finger
Family	IPR050701	Histone Modification Regulator
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type

Domain Details Per Protein

Protein	Length	AF-10/AF-17, PHD finger	AF-10, extended PHD finger	AF10-like, coiled-coil domain	Extended PHD (ePHD) domain	Histone Modification Regulator	Zinc finger, FYVE/PHD-type	Zinc finger, PHD-finger	Zinc finger, PHD-type	Zinc finger, PHD-type, conserved site	Zinc finger, RING/FYVE/PHD-type
UniProtKB:F8W451 InterPro	1133
UniProtKB:A0A8M6YVP0 InterPro	1162
UniProtKB:A0A8M3AZ26 InterPro	1090
UniProtKB:A0A8M6Z452 InterPro	1161
UniProtKB:A0A8M6Z457 InterPro	951
UniProtKB:A0A8M6YVP4 InterPro	1100
UniProtKB:A0A8M6YWB4 InterPro	916
UniProtKB:A0A8M6Z4S2 InterPro	1132
UniProtKB:A0A8M3AP65 InterPro	1120
UniProtKB:A0A8M9PUD9 InterPro	1131
UniProtKB:A0A8M6YY56 InterPro	1154
UniProtKB:A0A8M6YWA9 InterPro	1158
UniProtKB:A0A8M6YY61 InterPro	908

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mllt10-201 (1) Ensembl	Ensembl	2,829 nt	Select Tool ZFIN BLAST
mRNA	mllt10-202 (1) Ensembl	Ensembl	3,069 nt	Select Tool ZFIN BLAST
mRNA	mllt10-204 (1) Ensembl	Ensembl	4,589 nt	Select Tool
mRNA	mllt10-206 (1) Ensembl	Ensembl	6,768 nt	Select Tool
mRNA	mllt10-208 (1) Ensembl	Ensembl	5,383 nt	Select Tool
mRNA	mllt10-212 (1) Ensembl	Ensembl	3,270 nt	Select Tool ZFIN BLAST
mRNA	mllt10-213 (1) Ensembl	Ensembl	3,156 nt	Select Tool ZFIN BLAST
mRNA	mllt10-214 (1) Ensembl	Ensembl	3,180 nt	Select Tool ZFIN BLAST
ncRNA	mllt10-004 (1) Ensembl	Ensembl	834 nt	Select Tool
ncRNA	mllt10-005 (1) Ensembl	Ensembl	840 nt	Select Tool
ncRNA	mllt10-006 (1) Ensembl	Ensembl	784 nt	Select Tool
ncRNA	mllt10-007 (1) Ensembl	Ensembl	714 nt	Select Tool
ncRNA	mllt10-008 (1) Ensembl	Ensembl	711 nt	Select Tool
ncRNA	mllt10-009 (1) Ensembl	Ensembl	849 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations