Gene
erbb3a
- ID
- ZDB-GENE-030916-3
- Name
- erb-b2 receptor tyrosine kinase 3a
- Symbol
- erbb3a Nomenclature History
- Previous Names
-
- erbb3
- im:7148890
- si:dz150i12.1
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable neuregulin binding activity and neuregulin receptor activity. Predicted to be involved in several processes, including negative regulation of apoptotic process; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in membrane. Predicted to be part of receptor complex. Predicted to be active in basal plasma membrane. Is expressed in epidermis; fin; glial cell; and heart. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2; lung adenocarcinoma; lung non-small cell carcinoma; and neuronal intestinal dysplasia type A. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7148890 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| lethal congenital contracture syndrome 2 | Alliance | ?Lethal congenital contractural syndrome 2 | 607598 |
| neuronal intestinal dysplasia type A | Alliance | Visceral neuropathy, familial, 1, autosomal recessive | 243180 |
| {?Erythroleukemia, familial, susceptibility to} | 133180 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000494 | Receptor L-domain |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR006211 | Furin-like cysteine-rich domain |
| Domain | IPR032778 | Growth factor receptor domain 4 |
| Family | IPR016245 | Tyrosine protein kinase, EGF/ERB/XmrK receptor |
| Family | IPR050122 | Receptor Tyrosine Kinase |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036941 | Receptor L-domain superfamily |
| Homologous_superfamily | IPR044912 | Epidermal growth factor receptor, juxtamembrane domain |
| Repeat | IPR006212 | Furin-like repeat |
Domain Details Per Protein
| Protein | Length | Epidermal growth factor receptor, juxtamembrane domain | Furin-like cysteine-rich domain | Furin-like repeat | Growth factor receptor cysteine-rich domain superfamily | Growth factor receptor domain 4 | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Receptor L-domain | Receptor L-domain superfamily | Receptor Tyrosine Kinase | Serine-threonine/tyrosine-protein kinase, catalytic domain | Tyrosine protein kinase, EGF/ERB/XmrK receptor |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q8AW81
|
1305 | |||||||||||||
|
UniProtKB:A0A8M2BCY9
|
1432 | |||||||||||||
|
UniProtKB:A0A8M2BD22
|
1438 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA | erbb3a-001 (1) | Havana | 3,918 nt | ||
| mRNA |
erbb3a-201
(1)
|
Ensembl | 3,918 nt | ||
| mRNA |
erbb3a-203
(1)
|
Ensembl | 6,282 nt | ||
| mRNA |
erbb3a-204
(1)
|
Ensembl | 412 nt | ||
| ncRNA |
erbb3a-002
(1)
|
Ensembl | 532 nt | ||
| ncRNA |
erbb3a-005
(1)
|
Ensembl | 519 nt |
Interactions and Pathways
Plasmids
No data available