Gene

erbb3a

ID

ZDB-GENE-030916-3

Name

erb-b2 receptor tyrosine kinase 3a

Symbol

erbb3a Nomenclature History

Previous Names

erbb3
im:7148890
si:dz150i12.1

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have transmembrane receptor protein tyrosine kinase activity. Predicted to be involved in several processes, including positive regulation of cell population proliferation; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to basal plasma membrane; integral component of plasma membrane; and receptor complex. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 2. Is expressed in epidermis; fin; glial cell; and heart. Orthologous to human ERBB3 (erb-b2 receptor tyrosine kinase 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 6 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7148890 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With erbb3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
lethal congenital contracture syndrome 2	Alliance	?Lethal congenital contractural syndrome 2	607598
neuronal intestinal dysplasia type A	Alliance	Visceral neuropathy, familial, 1, autosomal recessive	243180
		{?Erythroleukemia, familial, susceptibility to}	133180

Associated With erbb3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000494	Receptor L-domain
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR006211	Furin-like cysteine-rich domain
Domain	IPR032778	Growth factor receptor domain 4
Family	IPR016245	Tyrosine protein kinase, EGF/ERB/XmrK receptor
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR036941	Receptor L-domain superfamily
Homologous_superfamily	IPR044912	Epidermal growth factor receptor, juxtamembrane domain
Repeat	IPR006212	Furin-like repeat

Domain Details Per Protein

Protein	Length	Epidermal growth factor receptor, juxtamembrane domain	Furin-like cysteine-rich domain	Furin-like repeat	Growth factor receptor cysteine-rich domain superfamily	Growth factor receptor domain 4	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Receptor L-domain	Receptor L-domain superfamily	Serine-threonine/tyrosine-protein kinase, catalytic domain	Tyrosine protein kinase, EGF/ERB/XmrK receptor
UniProtKB:Q8AW81 InterPro	1305
UniProtKB:A0A8M2BCY9 InterPro	1432
UniProtKB:A0A8M2BD22 InterPro	1438

Transcripts

Genome Browsers

UCSC

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	erbb3a-001 (1)	Havana	3918 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	erbb3a-203 (1) Ensembl	Havana	6282 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	erbb3a-204 (1) Ensembl	Havana	412 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	erbb3a-002 (1) Ensembl	Havana	532 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	erbb3a-005 (1) Ensembl	Havana	519 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations