Gene

nrp1a

ID

ZDB-GENE-030519-2

Name

neuropilin 1a

Symbol

nrp1a Nomenclature History

Previous Names

np-1
npn-1A (1)
nrp1
znrp1
zgc:111785 (1)
zgc:136674 (1)

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Exhibits vascular endothelial growth factor-activated receptor activity. Involved in several processes, including animal organ development; circulatory system development; and generation of neurons. Predicted to localize to integral component of membrane. Is expressed in several structures, including blood vasculature; cranial neural crest cell; hematopoietic stem cell; hypochord; and nervous system. Orthologous to human NRP1 (neuropilin 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

39 figures from 31 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 13 figures from 12 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nrp1a Human Ortholog

No data available

Associated With nrp1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000421	Coagulation factor 5/8 C-terminal domain
Domain	IPR000859	CUB domain
Domain	IPR000998	MAM domain
Domain	IPR022579	Neuropilin, C-terminal
Family	IPR014648	Neuropilin
Homologous_superfamily	IPR008979	Galactose-binding-like domain superfamily
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR035914	Spermadhesin, CUB domain superfamily

Domain Details Per Protein

Protein	Length	Coagulation factor 5/8 C-terminal domain	Concanavalin A-like lectin/glucanase domain superfamily	CUB domain	Galactose-binding-like domain superfamily	MAM domain	Neuropilin	Neuropilin, C-terminal	Spermadhesin, CUB domain superfamily
UniProtKB:A0A0R4IFP8 InterPro	926
UniProtKB:Q8QFX6 InterPro	923
UniProtKB:Q69DB8 InterPro	923
UniProtKB:A0A8M3AYV8 InterPro	919
UniProtKB:Q1RLY9 InterPro	916

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	nrp1a-201 (1) Ensembl	Havana	3875 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	nrp1a-202 (1) Ensembl	Havana	3644 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	nrp1a-203 (1) Ensembl	Havana	1977 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations