Gene
foxi1
- ID
- ZDB-GENE-030505-1
- Name
- forkhead box i1
- Symbol
- foxi1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity. Acts upstream of or within several processes, including embryonic organ morphogenesis; epidermal cell fate specification; and nervous system development. Predicted to be located in nucleus. Is expressed in several structures, including ectoderm; epibranchial ganglion; head; neural crest; and neurogenic field. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 4. Orthologous to several human genes including FOXI2 (forkhead box I2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 70 figures from 46 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb724 (51 images)
Wild Type Expression Summary
- All Phenotype Data
- 38 figures from 19 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| em1 | Allele with one delins | Unknown | Frameshift | spontaneous | |
| foxi1_unspecified | Unspecified Allele | Unknown | Unknown | not specified | |
| hi1321Tg | Transgenic insertion | 3' UTR | Unknown | DNA | |
| hi1359aTg | Transgenic insertion | Exon 2 | Unknown | DNA | |
| hi3239Tg | Transgenic insertion | Exon 2 | Unknown | DNA | |
| hi3747Tg | Transgenic insertion | Exon 1 | Unknown | DNA | |
| m271 | unknown | Unknown | Unknown | ENU | |
| m809 | Allele with one point mutation | Unknown | Missense | ENU |
1 - 8 of 8
Show
1 - 10 of 15
Show
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 4 | Alliance | Enlarged vestibular aqueduct | 600791 |
1 - 1 of 1
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018122 | Fork head domain conserved site1 |
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Family | IPR050211 | Forkhead box domain-containing protein |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
1 - 5 of 6 Show all
Domain Details Per Protein
| Protein | Length | Forkhead box domain-containing protein | Fork head domain | Fork head domain conserved site1 | Fork head domain conserved site 2 | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q804B2
|
377 |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(foxi1:d2EGFP) |
|
| 1 | (3) | |
| Tg(HSE-CMV:foxi1,EGFP) |
|
| 1 | Yao et al., 2014 | |
| Tg(hsp70l:foxi1) |
|
| 1 | (4) |
1 - 3 of 3
Show
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-329N5 | ZFIN Curated Data | |
| Encodes | EST | cb724 | Thisse et al., 2001 | |
| Encodes | cDNA | MGC:92424 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191985 | ZFIN Curated Data |
1 - 4 of 4
Show
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_181735 (1) | 1597 nt | ||
| Genomic | GenBank:CU914622 (2) | 112193 nt | ||
| Polypeptide | UniProtKB:Q804B2 (1) | 377 aa |
- Saunders, L.M., Srivatsan, S.R., Duran, M., Dorrity, M.W., Ewing, B., Linbo, T.H., Shendure, J., Raible, D.W., Moens, C.B., Kimelman, D., Trapnell, C. (2023) Embryo-scale reverse genetics at single-cell resolution. Nature. 623(7988):782-791
- Chen, X., Huang, Y., Gao, P., Lv, Y., Jia, D., Sun, K., Han, Y., Hu, H., Tang, Z., Ren, X., Liu, M. (2021) Knockout of mafba Causes Inner-Ear Developmental Defects in Zebrafish via the Impairment of Proliferation and Differentiation of Ionocyte Progenitor Cells. Biomedicines. 9(11):
- Greenfeld, H., Lin, J., Mullins, M.C. (2021) The BMP signaling gradient is interpreted through concentration thresholds in dorsal-ventral axial patterning. PLoS Biology. 19:e3001059
- Weuring, W.J., Dilevska, I., Hoekman, J., van de Vondervoort, J., Koetsier, M., van 't Slot, R.H., Braun, K.P.J., Koeleman, B.P.C. (2021) CRISPRa-Mediated Upregulation of scn1laa During Early Development Causes Epileptiform Activity and dCas9-Associated Toxicity. The CRISPR journal. 4:575-582
- He, M., Zhang, R., Jiao, S., Zhang, F., Ye, D., Wang, H., Sun, Y. (2020) Nanog safeguards early embryogenesis against global activation of maternal β-catenin activity by interfering with TCF factors. PLoS Biology. 18:e3000561
- Liu, Y., Zhu, Z., Ho, I.H.T., Shi, Y., Li, J., Wang, X., Chan, M.T.V., Cheng, C.H.K. (2020) Genetic Deletion of miR-430 Disrupts Maternal-Zygotic Transition and Embryonic Body Plan. Frontiers in genetics. 11:853
- Rogers, K.W., ElGamacy, M., Jordan, B.M., Müller, P. (2020) Optogenetic investigation of BMP target gene expression diversity. eLIFE. 9:
- Soh, G.H., Pomreinke, A.P., Müller, P. (2020) Integration of Nodal and BMP Signaling by Mutual Signaling Effector Antagonism. Cell Reports. 31:107487
- Zeng, C.W., Sheu, J.C., Tsai, H.J. (2020) A new member of the forkhead box protein family in zebrafish: Domain composition, phylogenetic implication and embryonic expression pattern. Gene expression patterns : GEP. 35:119093
- Ye, D., Wang, X., Wei, C., He, M., Wang, H., Wang, Y., Zhu, Z., Sun, Y. (2019) Marcksb plays a key role in the secretory pathway of zebrafish Bmp2b. PLoS Genetics. 15:e1008306
1 - 10 of 90
Show