Gene
gpx4b
- ID
- ZDB-GENE-030410-3
- Name
- glutathione peroxidase 4b
- Symbol
- gpx4b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. Involved in negative regulation of Wnt signaling pathway. Predicted to localize to mitochondrion and nucleus. Is expressed in several structures, including alar plate midbrain region; blastoderm; digestive system; musculature system; and visual system. Orthologous to human GPX4 (glutathione peroxidase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb692 (20 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondylometaphyseal dysplasia Sedaghatian type | Alliance | Spondylometaphyseal dysplasia, Sedaghatian type | 250220 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Glutathione peroxidase | Glutathione peroxidase active site | Glutathione peroxidase conserved site | Thioredoxin-like superfamily |
|---|---|---|---|---|---|
|
UniProtKB:B5DDU3
|
112 | ||||
|
UniProtKB:A0A8M1N743
|
191 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-gpx4 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
2 |
Plasmids
No data available