Gene

gpx4b

ID
ZDB-GENE-030410-3
Name
glutathione peroxidase 4b
Symbol
gpx4b Nomenclature History
Previous Names
  • cb692 (1)
  • PHGPxb (1)
  • zgc:110018
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to have glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. Involved in negative regulation of Wnt signaling pathway. Predicted to localize to mitochondrion and nucleus. Is expressed in several structures, including alar plate midbrain region; blastoderm; digestive system; musculature system; and visual system. Orthologous to human GPX4 (glutathione peroxidase 4).
Genome Resources
Note
None
Expression
All Expression Data
13 figures from 5 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gpx4b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Spondylometaphyseal dysplasia, Sedaghatian type 250220
Associated With gpx4b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR029759 Glutathione peroxidase active site
Conserved_site IPR029760 Glutathione peroxidase conserved site
Family IPR000889 Glutathione peroxidase
Homologous_superfamily IPR036249 Thioredoxin-like superfamily
Domain Details Per Protein
Protein Length Glutathione peroxidase Glutathione peroxidase active site Glutathione peroxidase conserved site Thioredoxin-like superfamily
UniProtKB:Q503Y1 112
UniProtKB:Q802G1 169
UniProtKB:A0A2R8RWH8 170
UniProtKB:C3S171 170
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-gpx4 polyclonal IgG Rabbit
  • IHC
  • WB
Santa Cruz Biotechnology, Inc.
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations