ZFIN ID: ZDB-GENE-030410-3
Gene Name: glutathione peroxidase 4b
Gene Symbol: gpx4b    Nomenclature History

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Previous Names: cb692 (1), PHGPxb (1), zgc:110018

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. Involved in negative regulation of Wnt signaling pathway. Predicted to localize to mitochondrion and nucleus. Is expressed in several structures, including alar plate midbrain region; blastoderm; digestive system; musculature system; and visual system. Orthologous to human GPX4 (glutathione peroxidase 4).
Genome Resources: Alliance (1),  Gene:352929 (1),  Ensembl(GRCz11):ENSDARG00000076836 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ouc1 Small Deletion Unknown Frameshift CRISPR
ouc2 Small Deletion Unknown Frameshift CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-gpx4b 1
MO1-gpx4b N/A 1
DISEASE ASSOCIATED WITH gpx4b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Spondylometaphyseal dysplasia, Sedaghatian type 250220
DISEASE ASSOCIATED WITH gpx4b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process negative regulation of Wnt signaling pathway (more)
Cellular Component mitochondrion (more)
Molecular Function glutathione peroxidase activity (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-gpx4 polyclonal IgG Rabbit IHC, WB Santa Cruz Biotechnology, Inc.
2
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM gpx4b No data available
MARKER RELATIONSHIPS
gpx4b Encodes: [EST] cb692 (1) (order this)
[cDNA] MGC:110018 (1), MGC:192986 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001030070 (1) 899 nt
Polypeptide UniProtKB:A0A2R8RWH8 (1) 170 aa
Sequence Information (all 25)
ORTHOLOGY for gpx4b ( Chr: 2 )
CITATIONS (40)