Gene

gpx4a

ID
ZDB-GENE-030410-2
Name
glutathione peroxidase 4a
Symbol
gpx4a Nomenclature History
Previous Names
  • cb563 (1)
  • cb691 (1)
  • PHGPxa (1)
  • sb:cb563
  • wu:fb82e03
  • zgc:92253
Type
protein_coding_gene
Location
Chr: 22 Mapping Details/Browsers
Description
Predicted to have glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. Predicted to be involved in response to oxidative stress. Predicted to localize to mitochondrion and nucleus. Is expressed in epidermal superficial stratum; gut; liver; otic vesicle; and yolk syncytial layer. Orthologous to human GPX4 (glutathione peroxidase 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
18 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Mendieta-Serrano et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gpx4a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Spondylometaphyseal dysplasia, Sedaghatian type 250220
Associated With gpx4a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR029759 Glutathione peroxidase active site
Conserved_site IPR029760 Glutathione peroxidase conserved site
Family IPR000889 Glutathione peroxidase
Homologous_superfamily IPR036249 Thioredoxin-like superfamily
Domain Details Per Protein
Protein Length Glutathione peroxidase Glutathione peroxidase active site Glutathione peroxidase conserved site Thioredoxin-like superfamily
UniProtKB:F6NSX3 186
UniProtKB:Q6DHK6 112
UniProtKB:D2CKK9 186
UniProtKB:Q802G2 163
UniProtKB:F6NPA3 176
UniProtKB:A0A140LG39 75
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-gpx4 polyclonal IgG Rabbit
  • IHC
  • WB
Santa Cruz Biotechnology, Inc.
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations