ZFIN is now using GRCz12tu for Genomic Data
Gene
gpx4a
- ID
- ZDB-GENE-030410-2
- Name
- glutathione peroxidase 4a
- Symbol
- gpx4a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable glutathione peroxidase activity and phospholipid-hydroperoxide glutathione peroxidase activity. Predicted to be involved in cellular response to oxidative stress and lipoxygenase pathway. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion and nucleus. Is expressed in epidermal superficial stratum; gut; liver; otic vesicle; and yolk syncytial layer. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma; colorectal cancer; and spondylometaphyseal dysplasia Sedaghatian type. Orthologous to human GPX4 (glutathione peroxidase 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 26 figures from 14 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb563 (7 images)
- cb691 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Mendieta-Serrano et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondylometaphyseal dysplasia Sedaghatian type | Alliance | Spondylometaphyseal dysplasia, Sedaghatian type | 250220 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glutathione peroxidase | Glutathione peroxidase active site | Glutathione peroxidase conserved site | Thioredoxin-like superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1N2T9 | InterPro | 186 | ||||
| UniProtKB:A0A8M1PAF3 | InterPro | 194 |
- Genome Browsers
Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-gpx4 | polyclonal | IgG | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
2 |
Plasmids
No data available
- Genome Browsers