ZFIN is now using GRCz12tu for Genomic Data
Gene
txnrd3
- ID
- ZDB-GENE-030327-3
- Name
- thioredoxin reductase 3
- Symbol
- txnrd3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable thioredoxin-disulfide reductase (NADPH) activity. Predicted to be involved in cell redox homeostasis. Predicted to be active in cytosol and mitochondrion. Is expressed in several structures, including digestive system; hematopoietic system; nervous system; pectoral fin musculature; and ventral mesoderm. Orthologous to human TXNRD3 (thioredoxin reductase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 22 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:64035 (1 image)
- cb682 (17 images)
- cb683 (19 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR011767 | Glutaredoxin active site |
| Active_site | IPR012999 | Pyridine nucleotide-disulphide oxidoreductase, class I, active site |
| Domain | IPR002109 | Glutaredoxin |
| Domain | IPR004099 | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain |
| Domain | IPR011899 | Glutaredoxin, eukaryotic/virial |
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Domain Details Per Protein
| Protein | Additional Resources | Length | FAD/NAD-linked reductase, dimerisation domain superfamily | FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain superfamily | Glutaredoxin | Glutaredoxin active site | Glutaredoxin, eukaryotic/virial | Glutathione reductase/thioredoxin reductase-like | Pyridine nucleotide-disulphide oxidoreductase, class I | Pyridine nucleotide-disulphide oxidoreductase, class I, active site | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain | Thioredoxin/glutathione reductase selenoprotein | Thioredoxin-like superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1PCD1 | InterPro | 602 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
txnrd3-201
(1)
|
Ensembl | 3,116 nt | ||
| mRNA |
txnrd3-202
(1)
|
Ensembl | 1,803 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Encodes | EST | cb682 | Thisse et al., 2001 | |
| Encodes | EST | cb683 | Thisse et al., 2001 | |
| Encodes | EST | fb83a08 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:64035 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:174821 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192941 | ZFIN Curated Data |
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- Genome Browsers
| Type | Accession # | Genome Assembly | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_183072 (1) | 3116 nt | ||
| Genomic | GenBank:HB912107 (1) | 1803 nt | ||
| Polypeptide | UniProtKB:A0A8M1PCD1 (1) | 602 aa |
No data available
- Li, H.Y., Zeng, W.L., Ye, Y.W., Chen, X., Zhang, M.M., Chen, Y.S., Liu, C.T., Zhong, Z.Q., Li, J., Wang, Y. (2025) Glia maturation factor-β in hepatocytes enhances liver regeneration and mitigates steatosis and ballooning in zebrafish. American journal of physiology. Gastrointestinal and liver physiology. :
- Üstündağ, Ü.V., Ünal, İ., Cansız, D., Beler, M., Kanagaraj, N.K., Kumar, A.R., Peravali, R., Emekli-Alturfan, E. (2024) 520 nm and 660 nm light-emitting diodes modulates pancreatic development and beta cell functions in zebrafish embryos. Photochemistry and photobiology. :
- Wang, H., Siren, J., Perttunen, S., Immonen, K., Chen, Y.C., Narumanchi, S., Kosonen, R., Paavola, J., Laine, M., Tikkanen, I., Lakkisto, P. (2024) Deficiency of heme oxygenase 1a causes detrimental effects on cardiac function. Journal of Cellular and Molecular Medicine. 28:e18243e18243
- Schoenmakers, E., Marelli, F., Jørgensen, H.F., Visser, W.E., Moran, C., Groeneweg, S., Avalos, C., Jurgens, S.J., Figg, N., Finigan, A., Wali, N., Agostini, M., Wardle-Jones, H., Lyons, G., Rusk, R., Gopalan, D., Twiss, P., Visser, J.J., Goddard, M., Nashef, S.A.M., Heijmen, R., Clift, P., Sinha, S., Pirruccello, J.P., Ellinor, P.T., Busch-Nentwich, E.M., Ramirez-Solis, R., Murphy, M.P., Persani, L., Bennett, M., Chatterjee, K. (2023) Selenoprotein deficiency disorder predisposes to aortic aneurysm formation. Nature communications. 14:79947994
- Kiledjian, N.T., Shah, R., Vetick, M.B., Copeland, P.R. (2022) The expression of essential selenoproteins during development requires SECIS-binding protein 2-like. Life science alliance. 5(5):
- Rana, A.K., Sharma, S., Saini, S.K., Singh, D. (2022) Rutin protects hemorrhagic stroke development via supressing oxidative stress and inflammatory events in a zebrafish model. European Journal of Pharmacology. 925:174973
- Facchinello, N., Laquatra, C., Locatello, L., Beffagna, G., Brañas Casas, R., Fornetto, C., Dinarello, A., Martorano, L., Vettori, A., Risato, G., Celeghin, R., Meneghetti, G., Santoro, M.M., Delahodde, A., Vanzi, F., Rasola, A., Dalla Valle, L., Rasotto, M.B., Lodi, T., Baruffini, E., Argenton, F., Tiso, N. (2021) Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish. Cell Death & Disease. 12:100
- Li, X., Liu, H., Li, D., Lei, H., Wei, X., Schlenk, D., Mu, J., Chen, H., Yan, B., Xie, L. (2021) Dietary Seleno-l-Methionine Causes Alterations in Neurotransmitters, Ultrastructure of the Brain, and Behaviors in Zebrafish (Danio rerio). Environmental science & technology. 55:11894-11905
- Sharma, S., Rana, A.K., Sharma, A., Singh, D. (2021) Inhibition of Mammalian Target of Rapamycin Attenuates Recurrent Seizures Associated Cardiac Damage in a Zebrafish Kindling Model of Chronic Epilepsy. Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 17(1-2):334-349
- Gu, Q., Ali, S.F., Kanungo, J. (2020) Effects of acetyl L-carnitine on zebrafish embryos: Phenotypic and gene expression studies. Journal of applied toxicology : JAT. 41(2):256-264
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