Gene

fanci

ID

ZDB-GENE-030131-2905

Name

FA complementation group I

Symbol

fanci Nomenclature History

Previous Names

fc21c10
wu:fc21c10
zgc:152941

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable DNA polymerase binding activity. Predicted to act upstream of or within DNA repair. Is expressed in central nervous system; head; heart; pectoral fin; and rostral blood island. Human ortholog(s) of this gene implicated in Fanconi anemia; Fanconi anemia complementation group I; and female breast cancer. Orthologous to human FANCI (FA complementation group I).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Titus et al., 2009

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Ramanagoudr-Bhojappa et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fanci Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Fanconi anemia complementation group I	Alliance	Fanconi anemia, complementation group I	609053

Associated With fanci Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR029305	FANCI solenoid 1 cap
Domain	IPR029308	FANCI solenoid 1 domain
Domain	IPR029310	FANCI helical domain 1
Domain	IPR029312	FANCI helical domain 2
Domain	IPR029313	FANCI solenoid 3 domain
Domain	IPR029314	FANCI solenoid 4 domain
Domain	IPR029315	FANCI solenoid 2 domain
Family	IPR026171	Fanconi anemia group I protein