Gene
cyp2ad2
- ID
- ZDB-GENE-020812-2
- Name
- cytochrome P450, family 2, subfamily AD, polypeptide 2
- Symbol
- cyp2ad2 Nomenclature History
- Previous Names
-
- cyp2j28
- cyp2ja
- fb62g08
- wu:fb62g08 (1)
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable heme binding activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen. Predicted to be involved in organic acid metabolic process and xenobiotic metabolic process. Predicted to be located in membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in intestine; kidney; liver; and spleen. Human ortholog(s) of this gene implicated in hypertension (multiple); myocardial infarction; and renal fibrosis. Orthologous to human CYP2J2 (cytochrome P450 family 2 subfamily J member 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa6633 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cytochrome P450 | Cytochrome P450, conserved site | Cytochrome P450, E-class, group I | Cytochrome P450, E-class, group I, CYP2D-like | Cytochrome P450 family 2 | Cytochrome P450 superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:Q98T96
|
492 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyp2ad2-201
(1)
|
Ensembl | 1,902 nt | ||
| ncRNA |
cyp2ad2-002
(1)
|
Ensembl | 500 nt | ||
| ncRNA |
cyp2ad2-003
(1)
|
Ensembl | 327 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-183N20 | ZFIN Curated Data | |
| Encodes | EST | fb62g08 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:56151 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192442 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_152954 (1) | 1915 nt | ||
| Genomic | GenBank:BX322665 (1) | 192437 nt | ||
| Polypeptide | UniProtKB:Q98T96 (1) | 492 aa |
No data available
- Nawaji, T., Yamashita, N., Umeda, H., Zhang, S., Mizoguchi, N., Seki, M., Kitazawa, T., Teraoka, H. (2020) Cytochrome P450 Expression and Chemical Metabolic Activity before Full Liver Development in Zebrafish. Pharmaceuticals (Basel, Switzerland). 13(12):
- So, J., Kim, M., Lee, S.H., Ko, S., Lee, D.A., Park, H., Azuma, M., Parsons, M.J., Prober, D., Shin, D. (2020) Attenuating the EGFR-ERK-SOX9 axis promotes liver progenitor cell-mediated liver regeneration in zebrafish. Hepatology (Baltimore, Md.). 73(4):1494-1508
- Wang, W., Ru, S., Wang, L., Qin, J., Ru, Y., Zhang, J., Zhang, X. (2020) Bisphenol S induces ectopic angiogenesis in embryos via VEGFR2 signaling, leading to lipid deposition in blood vessels of larval zebrafish. Environmental science & technology. 54(11):6822-6831
- Kubota, A., Kawai, Y.K., Yamashita, N., Lee, J.S., Kondoh, D., Zhang, S., Nishi, Y., Suzuki, K., Kitazawa, T., Teraoka, H. (2019) Transcriptional profiling of cytochrome P450 genes in the liver of adult zebrafish, Danio rerio. The Journal of Toxicological Sciences. 44:347-356
- Puthumana, J., Kim, B.M., Jeong, C.B., Kim, D.H., Kang, H.M., Jung, J.H., Kim, I.C., Hwang, U.K., Lee, J.S. (2017) Nine co-localized cytochrome P450 genes of the CYP2N, CYP2AD, and CYP2P gene families in the mangrove killifish Kryptolebias marmoratus genome: Identification and expression in response to B[α]P, BPA, OP, and NP. Aquatic toxicology (Amsterdam, Netherlands). 187:132-140
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Hu, P., Liu, M., Zhang, D., Wang, J., Niu, H., Liu, Y., Wu, Z., Han, B., Zhai, W., Shen, Y., Chen, L. (2015) Global identification of the genetic networks and cis-regulatory elements of the cold response in zebrafish. Nucleic acids research. 43(19):9198-213
- Zheng, W., Xu, H., Lam, S.H., Luo, H., Karuturi, R.K., and Gong, Z. (2013) Transcriptomic analyses of sexual dimorphism of the zebrafish liver and the effect of sex hormones. PLoS One. 8(1):e53562
- Warner, C.M., Gust, K.A., Stanley, J.K., Habib, T., Wilbanks, M.S., Garcia-Reyero, N., and Perkins, E.J. (2012) A Systems Toxicology Approach to Elucidate the Mechanisms Involved in RDX Species-Specific Sensitivity. Environmental science & technology. 46(14):7790-7798
- Kirischian, N., McArthur, A.G., Jesuthasan, C., Krattenmacher, B., and Wilson, J.Y. (2011) Phylogenetic and Functional Analysis of the Vertebrate Cytochrome P450 2 Family. Journal of molecular evolution. 72(1):56-71
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