Gene
abl2
- ID
- ZDB-GENE-020809-2
- Name
- c-abl oncogene 2, non-receptor tyrosine kinase
- Symbol
- abl2 Nomenclature History
- Previous Names
-
- cb272 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable protein tyrosine kinase activity. Predicted to be involved in epidermal growth factor receptor signaling pathway. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in plasma membrane. Is expressed in adaxial cell; myotome; and somite. Orthologous to human ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from Thisse et al., 2001
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb272 (6 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR015015 | F-actin binding |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR035837 | Tyrosine-protein kinase ABL, SH2 domain |
| Family | IPR050198 | Non-receptor tyrosine kinases involved in cell signaling |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | F-actin binding | Non-receptor tyrosine kinases involved in cell signaling | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily | Tyrosine-protein kinase ABL, SH2 domain | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2BEX3 | InterPro | 1134 | |||||||||||||
| UniProtKB:A0A8M2BE86 | InterPro | 1181 | |||||||||||||
| UniProtKB:A0A8M6Z7N2 | InterPro | 1125 | |||||||||||||
| UniProtKB:B0UXN7 | InterPro | 1135 | |||||||||||||
| UniProtKB:A0A0R4IYB8 | InterPro | 1182 |
Interactions and Pathways
No data available
Plasmids
No data available