Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-020509-2
Gene Name: gastrulation brain homeo box 2
Gene Symbol: gbx2
Previous Names: gbx-2 (1), fd07f12, wu:fd07f12 (1)
Nomenclature History
GENE EXPRESSION
All Expression Data: 23 figures from 13 publications
Directly Submitted Expression Data: 10 figures (39 images) from Rhinn et al., 2003 [mb2]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Long-pec (48.0h-60.0h)
  caudal fin, cerebellum, diencephalon, ectoderm (all 20) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 5 genotypes
Alleles: e30, fh248, fh253, gbx2_unrecovered
Knockdown reagents: MO1-gbx2 (1)
PHENOTYPE
Data: 4 figures from Burroughs-Garcia et al., 2011
Observed in: cell proliferation in forebrain, cell proliferation in hindbrain, cranial nerve V motor neuron, cranial nerve V neuronal cell body (all 10) expand
GENE ONTOLOGY
Ontology GO Term
Biological Process hindbrain development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • InterPro:IPR020479 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA gbx2-001 (1) 2095
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM gbx2
    Tg(gbx2.1-hsp70l:EGFP), Tg(gbx2.2-hsp70l:EGFP), Tg(gbx2.4-hsp70l:EGFP), Tg(hsp70l:gbx2), Tg3(gbx2-hsp70l:EGFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    gbx2 Contained in: [BAC] DKEY-30F11 (1)
    gbx2 Encodes: [EST] fd07f12 (1), mb2 (1)
    [cDNA] MGC:73023 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_152964 (1) 2113 bp
    Genomic GenBank:CR847983 (1) 199111 bp
    Select Tool
    Polypeptide UniProtKB:Q8AXK9 (1) 342 aa
    Sequence Clusters UniGene:17548 (1)
    Sequence Information (all 18)
    OTHER gbx2 GENE PAGES
  • Gene:245948 (1)
  • VEGA:OTTDARG00000034418 (1)
  • Ensembl(Zv9):ENSDARG00000002933 (1)
  • MAPPING INFORMATION
    Chr: 6 Details View Map: Merged   Individual Panels
    ORTHOLOGY
      Evidence
    Species Symbol Chromosome (Position) Accession # AA CL
    Zebrafish gbx2 6  
    Human GBX2 2 (2q37.2)
  • OMIM:601135
  • Gene:2637
  • Mouse Gbx2 1 ( 45.06 cM)
  • MGI:95668
  • Gene:14472
  • CITATIONS (42)