Gene
atp6ap1b
- ID
- ZDB-GENE-020423-2
- Name
- ATPase H+ transporting accessory protein 1b
- Symbol
- atp6ap1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable ATPase activator activity. Acts upstream of or within several processes, including Kupffer's vesicle development; apical protein localization; and pigment granule organization. Located in plasma membrane. Is expressed in several structures, including Kupffer's vesicle; digestive system; forerunner cell group; integument; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in immunodeficiency 47. Orthologous to human ATP6AP1 (ATPase H+ transporting accessory protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 15 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:103523 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 24 figures from 8 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-atp6ap1b | N/A | Gokey et al., 2015 |
| MO2-atp6ap1b | N/A | Gokey et al., 2015 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| immunodeficiency 47 | Alliance | Immunodeficiency 47 | 300972 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | V0 complex accessory subunit Ac45 | V-type proton ATPase subunit S1, luminal domain | V-type proton ATPase subunit S1/VOA1, transmembrane domain |
|---|---|---|---|---|---|
| UniProtKB:A2AR67 | InterPro | 459 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
atp6ap1b-201
(1)
|
Ensembl | 2,347 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-atp6ap1 | polyclonal | IgG | Rabbit |
|
Sigma-Aldrich
|
1 |
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Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| Tg(QUAS:atp6ap1b-GFP,cryaa:mCherry) |
| 1 | Levic et al., 2020 | ||
| Tg(QUAS:atp6ap1b-HA-BioID2,cryaa:mCherry) |
| 1 | Levic et al., 2020 |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-78K11 | ZFIN Curated Data | |
| Encodes | EST | fb33b05 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:103523 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:191717 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_173265 (1) | 2344 nt | ||
| Genomic | GenBank:AL845287 (2) | 174301 nt | ||
| Polypeptide | UniProtKB:A2AR67 (1) | 459 aa |
- Li, Y., Liu, C., Bai, X., Li, M., Duan, C. (2023) FK506-binding protein 5 regulates cell quiescence-proliferation decision in zebrafish epithelium. FEBS letters. 597(14):1868-1879
- Levic, D.S., Ryan, S., Marjoram, L., Honeycutt, J., Bagwell, J., Bagnat, M. (2020) Distinct roles for luminal acidification in apical protein sorting and trafficking in zebrafish. The Journal of cell biology. 219(4):
- Fillatre, J., Fauny, J.D., Fels, J.A., Li, C., Goll, M., Thisse, C., Thisse, B. (2019) TEADs, Yap, Taz, Vgll4s transcription factors control the establishment of Left-Right asymmetry in Zebrafish. eLIFE. 8:
- Meireles, A.M., Shen, K., Zoupi, L., Iyer, H., Bouchard, E.L., Williams, A., Talbot, W.S. (2018) The Lysosomal Transcription Factor TFEB Represses Myelination Downstream of the Rag-Ragulator Complex. Developmental Cell. 47:319-330.e5
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Slade, L., Cowie, A., Martynuik, C.J., Kienesberger, P.C., Pulinilkunnil, T. (2017) Dieldrin Augments mTOR Signaling and Regulates Genes Associated with Cardiovascular Disease in the Adult Zebrafish Heart (Danio rerio).. The Journal of pharmacology and experimental therapeutics. 361(3):375-385
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gokey, J.J., Dasgupta, A., Amack, J.D. (2015) The V-ATPase accessory protein Atp6ap1b mediates dorsal forerunner cell proliferation and left-right asymmetry in zebrafish. Developmental Biology. 407(1):115-30
- Ramos-Balderas, J.L., Carrillo-Rosas, S., Guzman, A., Navarro, R.E., and Maldonado, E. (2013) The zebrafish mutants for the V-ATPase subunits d, ac45, E, H and c and their variable pigment dilution phenotype. BMC research notes. 6:39
- Eauclaire, S.F., Cui, S., Ma, L., Matous, J., Marlow, F.L., Gupta, T., Burgess, H.A., Abrams, E.W., Kapp, L.D., Granato, M., Mullins, M.C., and Matthews, R.P. (2012) Mutations in vacuolar H(+)-ATPase subunits lead to biliary developmental defects in zebrafish. Developmental Biology. 365(2):434-444
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