ZFIN ID: ZDB-GENE-020423-2
Gene Name: ATPase H+ transporting accessory protein 1b
Gene Symbol: atp6ap1b    Nomenclature History

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Previous Names: atp6ap1, atp6s1, bbl, bleached blond, etID36826.23 (1), fb33b05, wu:fb33b05 (1), zgc:103523

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have proton-transporting ATP synthase activity, rotational mechanism and proton-transporting ATPase activity, rotational mechanism. Involved in several processes, including Kupffer's vesicle development; pigment granule organization; and retinal pigment epithelium development. Localizes to plasma membrane. Is expressed in several structures, including Kupffer's vesicle; digestive system; forerunner cell group; integument; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human ATP6AP1 (ATPase H+ transporting accessory protein 1).
Genome Resources: Alliance (1),  Gene:195824 (1),  Ensembl(GRCz11):ENSDARG00000037153 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
au82 Point Mutation Unknown Premature Stop ENU
hi112Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24346 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-atp6ap1b N/A 1
    MO2-atp6ap1b N/A 1
    DISEASE ASSOCIATED WITH atp6ap1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Immunodeficiency 47 300972
    DISEASE ASSOCIATED WITH atp6ap1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of heart looping (more)
    Cellular Component plasma membrane (more)
    Molecular Function proton-transporting ATPase activity, rotational mechanism (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA atp6ap1b-201 (1)    Ensembl 2347
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-atp6ap1 polyclonal IgG Rabbit IHC, WB Sigma-Aldrich
    1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM atp6ap1b No data available
    MARKER RELATIONSHIPS
    atp6ap1b Contained in: [BAC] DKEY-78K11 (1) (order this)
    atp6ap1b Encodes: [EST] fb33b05 (1)
    [cDNA] MGC:103523 (1), MGC:191717 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_173265 (1) 2034 nt
    Genomic GenBank:AL845287 (1) 174301 nt
    Select Tool
    Polypeptide UniProtKB:A2AR67 (1) 459 aa
    Sequence Information (all 19)
    ORTHOLOGY for atp6ap1b ( Chr: 23 )
    CITATIONS (38)