Gene
tfe3a
- ID
- ZDB-GENE-010919-2
- Name
- transcription factor binding to IGHM enhancer 3a
- Symbol
- tfe3a Nomenclature History
- Previous Names
-
- cb873 (1)
- zgc:109815
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including hindbrain neural plate; intermediate cell mass of mesoderm; solid lens vesicle; ventral mesoderm; and yolk syncytial layer. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human TFE3 (transcription factor binding to IGHM enhancer 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb873 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Allele | Type | Localization | Consequence | Mutagen | Supplier |
---|---|---|---|---|---|
la026694Tg | Transgenic insertion | Unknown | Unknown | DNA | |
sa7120 | Allele with one point mutation | Unknown | Splice Site | ENU | |
st124 | Allele with one deletion | Exon 2 | Unknown | CRISPR |
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Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
renal cell carcinoma | Alliance | Renal cell carcinoma, papillary, 1 | 300854 |
Intellectual developmental disorder, X-linked syndromic, with pigmentary mosaicism and coarse facies | 301066 |
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Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Helix-loop-helix DNA-binding domain superfamily | MiT/TFE transcription factors, C-terminal | MiT/TFE transcription factors, N-terminal | Myc-type, basic helix-loop-helix (bHLH) domain |
---|---|---|---|---|---|
UniProtKB:A0A8M2BE60
|
442 | ||||
UniProtKB:Q561Z2
|
539 | ||||
UniProtKB:A0A8M2BE83
|
292 |
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Interactions and Pathways
No data available
Plasmids
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-242K1 | ZFIN Curated Data | |
Encodes | EST | cb873 | Thisse et al., 2001 | |
Encodes | cDNA | MGC:109815 | ZFIN Curated Data | |
Encodes | cDNA | MGC:193046 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_131848 (1) | 2205 nt | ||
Genomic | GenBank:CR931813 (1) | 150062 nt | ||
Polypeptide | UniProtKB:Q561Z2 (1) | 539 aa |
- Ritter, D.J., Choudhary, D., Unlu, G., Knapik, E.W. (2023) Rgp1 contributes to craniofacial cartilage development and Rab8a-mediated collagen II secretion. Frontiers in endocrinology. 14:11204201120420
- Iyer, H., Shen, K., Meireles, A.M., Talbot, W.S. (2022) A lysosomal regulatory circuit essential for the development and function of microglia. Science advances. 8:eabp8321
- Pohl, J., Golovko, O., Carlsson, G., Örn, S., Schmitz, M., Ahi, E.P. (2021) Gene co-expression network analysis reveals mechanisms underlying ozone-induced carbamazepine toxicity in zebrafish (Danio rerio) embryos. Chemosphere. 276:130282
- Li, M., Zhu, F., and Hong, Y. (2013) Differential evolution of duplicated medakafish mitf genes. International journal of biological sciences. 9(5):496-508
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Lister, J.A., Lane, B.M., Nguyen, A., and Lunney, K. (2011) Embryonic expression of zebrafish MiT family genes tfe3b, tfeb, and tfec. Developmental Dynamics : an official publication of the American Association of Anatomists. 240:2529-2538
- Fu, Y.F., Du, T.T., Dong, M., Zhu, K.Y., Jing, C.B., Zhang, Y., Wang, L., Fan, H.B., Chen, Y., Jin, Y., Yue, G.P., Chen, S.J., Chen, Z., Huang, Q.H., Jing, Q., Deng, M., and Liu, T.X. (2009) Mir-144 selectively regulates embryonic {alpha}-hemoglobin synthesis during primitive erythropoiesis. Blood. 113(6):1340-1349
- Morley, R.H., Lachani, K., Keefe, D., Gilchrist, M.J., Flicek, P., Smith, J.C., and Wardle, F.C. (2009) A gene regulatory network directed by zebrafish No tail accounts for its roles in mesoderm formation. Proceedings of the National Academy of Sciences of the United States of America. 106(10):3829-3834
- Wang, Y., Chen, K., Yao, Q., Zheng, X., and Yang, Z. (2009) Phylogenetic Analysis of Zebrafish Basic Helix-Loop-Helix Transcription Factors. Journal of molecular evolution. 68(6):629-640
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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