Gene

tfe3a

ID
ZDB-GENE-010919-2
Name
transcription factor binding to IGHM enhancer 3a
Symbol
tfe3a Nomenclature History
Previous Names
  • cb873 (1)
  • zgc:109815
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Acts upstream of or within DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including hindbrain neural plate; intermediate cell mass of mesoderm; solid lens vesicle; ventral mesoderm; and yolk syncytial layer. Human ortholog(s) of this gene implicated in renal cell carcinoma. Orthologous to human TFE3 (transcription factor binding to IGHM enhancer 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Allele Type Localization Consequence Mutagen Supplier
la026694TgTransgenic insertionUnknownUnknownDNA
sa7120Allele with one point mutationUnknownSplice SiteENU
st124Allele with one deletionExon 2UnknownCRISPR
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Sequence Targeting Reagents
Targeting Reagent Created Alleles Citations
CRISPR1-tfe3aIyer et al., 2022
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Human Disease
Associated With tfe3a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
renal cell carcinoma Alliance Renal cell carcinoma, papillary, 1 300854
Intellectual developmental disorder, X-linked syndromic, with pigmentary mosaicism and coarse facies 301066
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Associated With tfe3a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Domain IPR021802 MiT/TFE transcription factors, C-terminal
Domain IPR031867 MiT/TFE transcription factors, N-terminal
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
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Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily MiT/TFE transcription factors, C-terminal MiT/TFE transcription factors, N-terminal Myc-type, basic helix-loop-helix (bHLH) domain
UniProtKB:A0A8M2BE60 442
UniProtKB:Q561Z2 539
UniProtKB:A0A8M2BE83 292
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Transcripts
Genome Browsers
Genome Build: GRCz11Chromosome: 8
Type Name Annotation Method Has Havana Data Length (nt) Analysis
mRNA tfe3a-201 (1) Ensembl 872 nt
mRNA tfe3a-202 (1) Ensembl 2,195 nt
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Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
No data available
Marker Relationships
Relationship Marker Type Marker Accession Numbers Citations
Contained inBACDKEY-242K1ZFIN Curated Data
EncodesESTcb873Thisse et al., 2001
EncodescDNAMGC:109815ZFIN Curated Data
EncodescDNAMGC:193046ZFIN Curated Data
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Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Species Symbol Chromosome Accession # Evidence
HumanTFE3X
Phylogenetic tree (1)
Amino acid sequence comparison (6)
Conserved genome location (synteny) (2)
MouseTfe3X
Amino acid sequence comparison (6)
Phylogenetic tree (1)
Conserved genome location (synteny) (1)
Citations
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