Gene
bambia
- ID
- ZDB-GENE-010416-1
- Name
- BMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a
- Symbol
- bambia Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable frizzled binding activity. Acts upstream of or within dorsal/ventral pattern formation; negative regulation of BMP signaling pathway; and platelet activation. Predicted to be located in plasma membrane. Is expressed in several structures, including eye; germ ring; integument; optic cup; and pectoral fin bud. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human BAMBI (BMP and activin membrane bound inhibitor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 27 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb998 (16 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from O'Connor et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-bambia | N/A | O'Connor et al., 2009 |
| MO2-bambia | N/A | O'Connor et al., 2009 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | BMP and activin membrane-bound inhibitor | BMP and activin membrane-bound inhibitor, C-terminal domain | BMP and activin membrane-bound inhibitor, N-terminal domain | Snake toxin-like superfamily |
|---|---|---|---|---|---|---|
| UniProtKB:Q9DFZ0 | InterPro | 258 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
bambia-201
(1)
|
Ensembl | 1,569 nt |
Interactions and Pathways
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-112K3 | ZFIN Curated Data | |
| Contains | SNP | rs3728472 | ZFIN Curated Data | |
| Contains | SNP | rs3728473 | ZFIN Curated Data | |
| Contains | SNP | rs3728474 | ZFIN Curated Data | |
| Encodes | EST | cb998 | Thisse et al., 2001 | |
| Encodes | EST | fc44c12 | ||
| Encodes | EST | fe01e03 | ZFIN Curated Data | |
| Encodes | EST | ibd5020 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:6910718 | Thisse et al., 2004 | |
| Encodes | cDNA | MGC:73034 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131784 (1) | 1560 nt | ||
| Genomic | GenBank:BX005058 (2) | 170139 nt | ||
| Polypeptide | UniProtKB:Q9DFZ0 (1) | 258 aa |
- Dong, X.R., Wan, S.M., Zhou, J.J., Nie, C.H., Chen, Y.L., Diao, J.H., Gao, Z.X. (2022) Functional Differentiation of BMP7 Genes in Zebrafish: bmp7a for Dorsal-Ventral Pattern and bmp7b for Melanin Synthesis and Eye Development. Frontiers in cell and developmental biology. 10:838721
- Greenfeld, H., Lin, J., Mullins, M.C. (2021) The BMP signaling gradient is interpreted through concentration thresholds in dorsal-ventral axial patterning. PLoS Biology. 19:e3001059
- Knickmeyer, M.D., Mateo, J.L., Heermann, S. (2021) BMP Signaling Interferes with Optic Chiasm Formation and Retinal Ganglion Cell Pathfinding in Zebrafish. International Journal of Molecular Sciences. 22(9):
- Zhang, G., Lübke, L., Chen, F., Beil, T., Takamiya, M., Diotel, N., Strähle, U., Rastegar, S. (2021) Neuron-Radial Glial Cell Communication via BMP/Id1 Signaling Is Key to Long-Term Maintenance of the Regenerative Capacity of the Adult Zebrafish Telencephalon. Cells. 10(10):
- Eckert, P., Knickmeyer, M.D., Heermann, S. (2020) In Vivo Analysis of Optic Fissure Fusion in Zebrafish: Pioneer Cells, Basal Lamina, Hyaloid Vessels, and How Fissure Fusion is Affected by BMP. International Journal of Molecular Sciences. 21(8):
- Rogers, K.W., ElGamacy, M., Jordan, B.M., Müller, P. (2020) Optogenetic investigation of BMP target gene expression diversity. eLIFE. 9:
- Zhang, G., Ferg, M., Lübke, L., Takamiya, M., Beil, T., Gourain, V., Diotel, N., Strähle, U., Rastegar, S. (2020) Bone morphogenetic protein signaling regulates Id1-mediated neural stem cell quiescence in the adult zebrafish brain via a phylogenetically conserved enhancer module. Stem cells (Dayton, Ohio). 38(7):875-889
- Eckert, P., Knickmeyer, M.D., Schütz, L., Wittbrodt, J., Heermann, S. (2019) Morphogenesis and axis specification occur in parallel during optic cup and optic fissure formation, differentially modulated by BMP and Wnt. Open Biology. 9:180179
- Richardson, R., Owen, N., Toms, M., Young, R.M., Tracey-White, D., Moosajee, M. (2019) Transcriptome profiling of zebrafish optic fissure fusion. Scientific Reports. 9:1541
- Dasgupta, S., Cheng, V., Vliet, S.M.F., Mitchell, C.A., Volz, D.C. (2018) Tris(1,3-dichloro-2-propyl) phosphate Exposure During Early-Blastula Alters the Normal Trajectory of Zebrafish Embryogenesis. Environmental science & technology. 52(18):10820-10828
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