Gene

ctbp2a

ID

ZDB-GENE-010130-2

Name

C-terminal binding protein 2a

Symbol

ctbp2a Nomenclature History

Previous Names

CtBP2 (1)
ctbp2
fe05b01
riba
ribeye a (1)
wu:fb96g03 (1)
wu:fe05b01 (1)
wu:fk19e02

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Predicted to have NAD binding activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in camera-type eye development; nervous system development; and regulation of melanocyte differentiation. Is expressed in nervous system; neural plate; otic vesicle; pectoral fin; and pharyngeal arch. Orthologous to human CTBP2 (C-terminal binding protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

21 figures from 9 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:77268 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 5 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ctbp2a Human Ortholog

No data available

Associated With ctbp2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR029753	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
Domain	IPR006139	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Domain	IPR006140	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
Family	IPR043322	C-terminal binding protein
Family	IPR051638	C-terminal-binding dehydrogenase
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily

Domain Details Per Protein

Protein	Length	C-terminal-binding dehydrogenase	C-terminal binding protein	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site	NAD(P)-binding domain superfamily
UniProtKB:Q5BU19 InterPro	1147
UniProtKB:Q9DEG6 InterPro	444

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ctbp2a-201 (1) Ensembl	Ensembl	3,746 nt	Select Tool ZFIN BLAST
mRNA	ctbp2a-202 (1) Ensembl	Ensembl	3,447 nt	Select Tool ZFIN BLAST
mRNA	ctbp2a-203 (1) Ensembl	Ensembl	3,035 nt	Select Tool ZFIN BLAST
mRNA	ctbp2a-204 (1) Ensembl	Ensembl	3,471 nt	Select Tool ZFIN BLAST
mRNA	ctbp2a-205 (1) Ensembl	Ensembl	825 nt	Select Tool ZFIN BLAST
mRNA	ctbp2a-206 (1) Ensembl	Ensembl	2,013 nt	Select Tool ZFIN BLAST
mRNA	ctbp2a-207 (1) Ensembl	Ensembl	2,877 nt	Select Tool ZFIN BLAST
mRNA	ctbp2a-208 (1) Ensembl	Ensembl	2,605 nt	Select Tool ZFIN BLAST
mRNA	ctbp2a-209 (1) Ensembl	Ensembl	1,197 nt	Select Tool ZFIN BLAST
mRNA	ctbp2a-210 (1) Ensembl	Ensembl	937 nt	Select Tool ZFIN BLAST
mRNA	ctbp2a-211 (1) Ensembl	Ensembl	765 nt	Select Tool ZFIN BLAST
mRNA	ctbp2a-212 (1) Ensembl	Ensembl	2,375 nt	Select Tool ZFIN BLAST
mRNA	ctbp2a-213 (1) Ensembl	Ensembl	592 nt	Select Tool ZFIN BLAST
mRNA	ctbp2a-214 (1) Ensembl	Ensembl	6,192 nt	Select Tool ZFIN BLAST
mRNA	ctbp2a-215 (1) Ensembl	Ensembl	6,395 nt	Select Tool ZFIN BLAST
mRNA	ctbp2a-216 (1) Ensembl	Ensembl	1,242 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
AB2-ctbp2a		ctbp2a		Chicken			1
Ab1-ctbp2a	polyclonal	ctbp2a		Rabbit	IHC		10

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations