ZFIN ID: ZDB-GENE-010130-2
Gene Name: C-terminal binding protein 2a
Gene Symbol: ctbp2a    Nomenclature History

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Previous Names: CtBP2 (1), ctbp2, fe05b01, riba, ribeye a (1), wu:fb96g03 (1), wu:fe05b01 (1), wu:fk19e02

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have NAD binding activity and oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Involved in camera-type eye development; nervous system development; and regulation of melanocyte differentiation. Is expressed in nervous system; neural plate; otic vesicle; pectoral fin; and pharyngeal arch. Orthologous to human CTBP2 (C-terminal binding protein 2).
Genome Resources: Alliance (1),  Gene:65230 (1),  Ensembl(GRCz11):ENSDARG00000044062 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020241Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la020242Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • nk17bEt Transgenic Insertion Unknown Unknown DNA
    sa297 Point Mutation Unknown Premature Stop ENU
    sa10746 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12314 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17809 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23003 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30695 Point Mutation Unknown Missense, Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32122 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32123 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32124 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42870 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42871 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ya400 Small Deletion Unknown Unknown ZINC_FINGER_NUCLEASE
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ctbp2a N/A 2
    MO2-ctbp2a N/A 2
    MO3-ctbp2a N/A 1
    MO4-ctbp2a N/A 1
    MO5-ctbp2a N/A 1
    MO6-ctbp2a N/A 1
    MO7-ctbp2a N/A 1
    MO8-ctbp2a N/A 1
    MO9-ctbp2a N/A 1
    DISEASE ASSOCIATED WITH ctbp2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ctbp2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process clustering of voltage-gated calcium channels (more)
    Molecular Function NAD binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR029753 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain conserved site
    Domain IPR006139 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
    Domain IPR006140 D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding domain
    Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ctbp2a-201 (1)    Ensembl 3746
    ctbp2a-203 (1)    Ensembl 3035
    ctbp2a-204 (1)    Ensembl 3471
    ctbp2a-205 (1)    Ensembl 825
    ctbp2a-206 (1)    Ensembl 2013
    ctbp2a-207 (1)    Ensembl 2877
    ctbp2a-208 (1)    Ensembl 2605
    ctbp2a-209 (1)    Ensembl 1197
    ctbp2a-210 (1)    Ensembl 937
    ctbp2a-211 (1)    Ensembl 765
    ctbp2a-212 (1)    Ensembl 2375
    ctbp2a-213 (1)    Ensembl 592
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    AB2-ctbp2a Chicken 1
    Ab1-ctbp2a polyclonal Rabbit IHC 9
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ctbp2a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-1.8ctbp2a:clta-EGFP) ctbp2a cltaEGFP Danio rerio 1 2
    Tg(-1.8ctbp2a:clta-mCherry) ctbp2a cltamCherry Danio rerio 1 2
    Tg(-1.8ctbp2a:dnm2a-EGFP) ctbp2a dnm2aEGFP Danio rerio 1 2
    Tg(-1.8ctbp2a:GAP-EGFP) ctbp2a EGFP Danio rerio 1 3
    Tg(-1.8ctbp2a:mCherry-ctbp2a) ctbp2a ctbp2amCherry Danio rerio 1 3
    Tg(-1.8ctbp2a:Rno.Syp-GCaMP2) ctbp2a GCaMP Danio rerioRattus norvegicus 1 9
    Tg(-1.8ctbp2a:Rno.Syp-GCaMP6) ctbp2a GCaMP Danio rerioRattus norvegicus 1 4
    Tg(-1.8ctbp2a:sypb-EGFP) ctbp2a EGFPsypb Danio rerio 1 2
    Tg(-1.8ctbp2a:SYPHY) ctbp2a SYPHY Danio rerio 1 6
    Tg(-6myo6b:ctbp2a-mCherry) myo6b ctbp2amCherry Danio rerio 1 2
    Tg(cryaa:mCherry,ctbp2a:NLS-Eco.TrpR-GAL4) cryaactbp2a GAL4mCherry Danio rerioEscherichia coli 1 4
    Tg(ctbp2a:Cr.ChR2-CFP) ctbp2a CFPChR2 Chlamydomonas reinhaDanio rerio 1 1
    Tg(myo6b:ctbp2a-mCherry) myo6b ctbp2amCherry Danio rerio 1 2
    Tg(myo6b:ctbp2a-TagRFP) myo6b ctbp2aTagRFP Danio rerio 0 1
    Tg(pvalb8:ctbp2a-mCherry) pvalb8 ctbp2amCherry Danio rerio 1 3
    Tg(pvalb9:ctbp2a-mCherry) pvalb9 ctbp2amCherry Danio rerio 1 1
    MARKER RELATIONSHIPS
    ctbp2a Contained in: [BAC] CH211-108I17 (1)
    ctbp2a Encodes: [EST] fe05b01 (1), fk19e02
    [cDNA] MGC:55495 (1), MGC:65878 (1), MGC:77268 (1), MGC:77355 (1), MGC:175158 (1), MGC:191960 (1)
    ctbp2a Has Artifact: [EST] fb96g03
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001195491 (1) 3444 nt
    Genomic GenBank:CU459182 (1) 142261 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QBA1 (1) 1200 aa
    Sequence Information (all 52)
    ORTHOLOGY for ctbp2a ( Chr: 17 )
    CITATIONS (57)