ZFIN ID: ZDB-GENE-001212-1
Gene Name: ATPase, Na+/K+ transporting, alpha 1a polypeptide, tandem duplicate 1
Gene Symbol: atp1a1a.1
Previous Names: atp1a1, atp[a]1B1 (1), cb70 (1), had (1), snk (1), heart and mind (1), snakehead (1), wu:fa03c03, wu:fb92h10 (1)
Location: Chr: 1   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 29 figures from 12 publications
Directly Submitted Expression Data: 6 figures (19 images) from Rauch et al., 2003 [fb81h09]
  6 figures (22 images) from Thisse et al., 2001 [cb70]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
  adaxial cell, alar plate midbrain region, blastomere, brain (all 35) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 24 Genotypes
Knockdown reagents: MO1-atp1a1a.1 (1), MO2-atp1a1a.1 (1), MO3-atp1a1a.1 (1)

Allele Type Mutagen Suppliers
hi3475Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la1 Indel SPONTANEOUS
    la028094Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m115 Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m273 Unknown ENU
    m291 Unknown
    m523 Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m883 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • mw15b Small Deletion ENU
    sa12184 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13646 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa15598 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa19398 Point Mutation ENU
    tj223 Unknown ENU
  • Nüsslein-Volhard Lab
  • European Zebrafish Resource Center (EZRC) (order this)
  • tl30 Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Nüsslein-Volhard Lab
  • tm52 Unknown ENU
  • Nüsslein-Volhard Lab
  • European Zebrafish Resource Center (EZRC) (order this)
  • to273a Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tu236 Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Nüsslein-Volhard Lab
  • tw3b Unknown ENU
  • Nüsslein-Volhard Lab
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE
    Data: 31 figures from 10 publications
    Observed in: anatomical system, blood circulation, brain, cell migration involved in heart formation (all 39) expand
    DISEASE ASSOCIATED WITH atp1a1a.1 HUMAN ORTHOLOG No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process otolith development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function sodium:potassium-exchanging ATPase activity (more)
    GO Terms (all 24)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001757 (1)
  • InterPro:IPR004014 (1)
  • InterPro:IPR005775 (1)
  • InterPro:IPR006068 (1)
  • InterPro:IPR008250 (1)
  • InterPro:IPR018303 (1)
  • InterPro:IPR023214 (1)
  • InterPro:IPR023298 (1)
  • InterPro:IPR023299 (1)
  • PROSITE:PS00154 (1)
  • Pfam:PF00122 (1)
  • Pfam:PF00689 (1)
  • Pfam:PF00690 (1)
  • Pfam:PF00702 (1)
  • Pfam:PF08282 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA atp1a1a.1-001 (1) 3506
    ncRNA atp1a1a.1-002 (1) 867
    atp1a1a.1-003 (1) 416
    atp1a1a.1-004 (1) 313
    atp1a1a.1-005 (1) 652
    atp1a1a.1-006 (1) 772
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab3-atp1a1 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM atp1a1a.1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    atp1a1a.1 Contained in: [BAC] DKEY-208K14 (1) (order this)
    atp1a1a.1 Encodes: [EST] cb70 (1) (order this), fa03c03 (1), fb81h09 (1) (order this), fb92h10 (1)
    [cDNA] MGC:55250 (1) (order this), MGC:77580 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131686 (1) 3497 bp
    Genomic GenBank:CU185242 (1) 180192 bp
    Select Tool
    Polypeptide UniProtKB:Q7ZU25 (1) 1028 aa
    Sequence Clusters UniGene:75307 (1)
    Sequence Information (all 25)
    OTHER atp1a1a.1 GENE PAGES
  • Gene:64612 (1)
  • VEGA:OTTDARG00000029782 (1)
  • Ensembl(Zv9):ENSDARG00000002791 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish atp1a1a.1 1  
    Human ATP1A1 1 (1p21)
  • OMIM:182310
  • Gene:476
  • Mouse Atp1a1 3 ( 44.30 cM)
  • MGI:88105
  • Gene:11928
  • Orthology Details
    CITATIONS (57)