Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-001212-1
Gene Name: ATPase, Na+/K+ transporting, alpha 1a polypeptide, tandem duplicate 1
Gene Symbol: atp1a1a.1
Previous Names: atp1a1, atp[a]1B1 (1), cb70 (1), had (1), snakehead (1), snk (1), heart and mind (1), wu:fa03c03, wu:fb92h10 (1)
Location: Chr: 1   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 29 figures from 12 publications
Directly Submitted Expression Data: 6 figures (19 images) from Rauch et al., 2003 [fb81h09]
  6 figures (22 images) from Thisse et al., 2001 [cb70]
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
  adaxial cell, alar plate midbrain region, blastomere, brain (all 35) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 24 genotypes
Alleles: hi3475Tg, la028094Tg, la1, m115, m273 (all 19) expand
Knockdown reagents: MO1-atp1a1a.1 (1), MO2-atp1a1a.1 (1), MO3-atp1a1a.1 (1)
PHENOTYPE
Data: 31 figures from 10 publications
Observed in: anatomical system, blood circulation, brain, cell migration involved in heart formation (all 39) expand
GENE ONTOLOGY
Ontology GO Term
Biological Process otolith development (more)
Cellular Component integral component of membrane (more)
Molecular Function sodium:potassium-exchanging ATPase activity (more)
GO Terms (all 25)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001757 (1)
  • InterPro:IPR004014 (1)
  • InterPro:IPR005775 (1)
  • InterPro:IPR006068 (1)
  • InterPro:IPR008250 (1)
  • InterPro:IPR018303 (1)
  • InterPro:IPR023214 (1)
  • InterPro:IPR023298 (1)
  • InterPro:IPR023299 (1)
  • PROSITE:PS00154 (1)
  • Pfam:PF00122 (1)
  • Pfam:PF00689 (1)
  • Pfam:PF00690 (1)
  • Pfam:PF00702 (1)
  • Pfam:PF08282 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA atp1a1a.1-001 (1) 3506
    ncRNA atp1a1a.1-002 (1) 867
    atp1a1a.1-003 (1) 416
    atp1a1a.1-004 (1) 313
    atp1a1a.1-005 (1) 652
    atp1a1a.1-006 (1) 772
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab3-atp1a1 (1)
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM atp1a1a.1 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    atp1a1a.1 Contained in: [BAC] DKEY-208K14 (1)
    atp1a1a.1 Encodes: [EST] cb70 (1) (order this), fa03c03 (1), fb81h09 (1), fb92h10 (1)
    [cDNA] MGC:55250 (1) (order this), MGC:77580 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131686 (1) 3497 bp
    Genomic GenBank:CU185242 (1) 180192 bp
    Select Tool
    Polypeptide UniProtKB:Q7ZU25 (1) 1028 aa
    Sequence Clusters UniGene:75307 (1)
    Sequence Information (all 25)
    OTHER atp1a1a.1 GENE PAGES
  • Gene:64612 (1)
  • VEGA:OTTDARG00000029782 (1)
  • Ensembl(Zv9):ENSDARG00000002791 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish atp1a1a.1 1  
    Human ATP1A1 1 (1p21)
  • OMIM:182310
  • Gene:476
  • Mouse Atp1a1 3 ( 44.30 cM)
  • MGI:88105
  • Gene:11928
  • Orthology Details
    CITATIONS (57)