Gene

hbs1l

ID

ZDB-GENE-030131-2987

Name

HBS1-like translational GTPase

Symbol

hbs1l Nomenclature History

Previous Names

wu:fc23c07
zgc:55400

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have GTPase activity. Predicted to be involved in translation. Human ortholog(s) of this gene implicated in beta thalassemia. Orthologous to human HBS1L (HBS1 like translational GTPase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:55400 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Cabrera-Quio et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hbs1l Human Ortholog

No data available

Associated With hbs1l Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000795	Translational (tr)-type GTP-binding domain
Domain	IPR004160	Translation elongation factor EFTu/EF1A, C-terminal
Domain	IPR004161	Translation elongation factor EFTu-like, domain 2
Domain	IPR015033	HBS1-like protein, N-terminal
Homologous_superfamily	IPR009000	Translation protein, beta-barrel domain superfamily
Homologous_superfamily	IPR009001	Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR037189	HBS1-like protein, N-terminal domain superfamily

Domain Details Per Protein

Protein	Length	HBS1-like protein, N-terminal	HBS1-like protein, N-terminal domain superfamily	P-loop containing nucleoside triphosphate hydrolase	Translational (tr)-type GTP-binding domain	Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal	Translation elongation factor EFTu/EF1A, C-terminal	Translation elongation factor EFTu-like, domain 2	Translation protein, beta-barrel domain superfamily
UniProtKB:A0A8M6YV72 InterPro	576
UniProtKB:F1Q5Z6 InterPro	682

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	hbs1l-201 (1) Ensembl	Havana	1204 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	hbs1l-203 (1) Ensembl	Havana	2424 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	hbs1l-003 (1) Ensembl	Havana	643 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations