ZFIN ID: ZDB-PERS-960805-299
Knapik, Ela W.
Email: ela.knapik@vanderbilt.edu
Affiliation: Knapik Lab
Address: Division of Genetic Medicine Department of Cell and Developmental Biology Developmental Biology Program Vanderbilt University 1165 Light Hall 2215 Garland Av. Nashville, TN 37232-0275 USA
Country: United States
Phone: (615) 322-7559
Fax: (615) 322-7549


Ritter, D.J., Choudhary, D., Unlu, G., Knapik, E.W. (2023) Rgp1 contributes to craniofacial cartilage development and Rab8a-mediated collagen II secretion. Frontiers in endocrinology. 14:11204201120420
Luderman, L.N., Michaels, M.T., Levic, D.S., Knapik, E.W. (2022) Zebrafish Erc1b mediates motor innervation and organization of craniofacial muscles in control of jaw movement. Developmental Dynamics : an official publication of the American Association of Anatomists. 252(1):104-123
Bayraktar, E.C., La, K., Karpman, K., Unlu, G., Ozerdem, C., Ritter, D.J., Alwaseem, H., Molina, H., Hoffmann, H.H., Millner, A., Atilla-Gokcumen, G.E., Gamazon, E.R., Rushing, A.R., Knapik, E.W., Basu, S., Birsoy, K. (2020) Metabolic coessentiality mapping identifies C12orf49 as a regulator of SREBP processing and cholesterol metabolism. Nature metabolism. 2:487-498
Unlu, G., Qi, X., Gamazon, E.R., Melville, D.B., Patel, N., Rushing, A.R., Hashem, M., Al-Faifi, A., Chen, R., Li, B., Cox, N.J., Alkuraya, F.S., Knapik, E.W. (2020) Phenome-based approach identifies RIC1-linked Mendelian syndrome through zebrafish models, biobank associations and clinical studies. Nature medicine. 26:98-109
Unlu, G., Gamazon, E.R., Qi, X., Levic, D.S., Bastarache, L., Denny, J.C., Roden, D.M., Mayzus, I., Breyer, M., Zhong, X., Konkashbaev, A.I., Rzhetsky, A., Knapik, E.W., Cox, N.J. (2019) GRIK5 Genetically Regulated Expression Associated with Eye and Vascular Phenomes: Discovery through Iteration among Biobanks, Electronic Health Records, and Zebrafish. American journal of human genetics. 104(3):503-519
Cox, N.J., Unlu, G., Bisnett, B.J., Meister, T.R., Condon, B., Luo, P.M., Smith, T.J., Hanna, M., Chhetri, A., Soderblom, E.J., Audhya, A., Knapik, E.W., Boyce, M. (2017) Dynamic glycosylation governs the vertebrate COPII protein trafficking pathway. Biochemistry. 57(1):91-107
Hockman, D., Burns, A., Schlosser, G., Gates, K.P., Jevans, B., Mongera, A., Fisher, S., Unlu, G., Knapik, E.W., Kaufman, C.K., Mosimann, C., Zon, L.I., Lancman, J.J., Dong, P.D., Lickert, H., Tucker, A.S., Baker, C.V. (2017) Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes. eLIFE. 6
Luderman, L.N., Unlu, G., Knapik, E.W. (2017) Zebrafish Developmental Models of Skeletal Diseases. Current topics in developmental biology. 124:81-124
Zou, P., Wu, S.Y., Koteiche, H.A., Mishra, S., Levic, D.S., Knapik, E., Chen, W., Mchaourab, H.S. (2015) A conserved role of αA-crystallin in the development of the zebrafish embryonic lens. Experimental Eye Research. 138:104-13
Levic, D.S., Minkel, J., Wang, W., Rybski, W.M., Melville, D.B., Knapik, E.W. (2015) Animal model of Sar1b deficiency presents lipid absorption deficits similar to Anderson disease. Journal of molecular medicine (Berlin, Germany). 93(2):165-176
Niu, X., Hong, J., Zheng, X., Melville, D.B., Knapik, E.W., Meng, A., Peng, J. (2014) The Nuclear Pore Complex Function of Sec13 Protein Is Required for Cell Survival during Retinal Development. The Journal of biological chemistry. 289:11971-85
Vacaru, A.M., Unlu, G., Spitzner, M., Mione, M., Knapik, E.W., and Sadler, K.C. (2014) In vivo cell biology in zebrafish - providing insights into vertebrate development and disease. Journal of Cell Science. 127(Pt 3):485-495
Venkateswaran, A., Sekhar, K.R., Levic, D.S., Melville, D.B., Clark, T.A., Rybski, W.M., Walsh, A.J., Skala, M.C., Crooks, P.A., Knapik, E.W., and Freeman, M.L. (2014) The NADH Oxidase ENOX1, a Critical Mediator of Endothelial Cell Radiosensitization, Is Crucial for Vascular Development. Cancer research. 74(1):38-43
Lee, R.T., Knapik, E.W., Thiery, J.P., and Carney, T.J. (2013) An exclusively mesodermal origin of fin mesenchyme demonstrates that zebrafish trunk neural crest does not generate ectomesenchyme. Development (Cambridge, England). 140(14):2923-2932
Müller, I.I., Melville, D.B., Tanwar, V., Rybski, W.M., Mukherjee, A., Shoemaker, B.M., Wang, W.D., Schoenhard, J.A., Roden, D.M., Darbar, D., Knapik, E.W., and Hatzopoulos, A.K. (2013) Functional modeling in zebrafish demonstrates that the atrial-fibrillation-associated gene GREM2 regulates cardiac laterality, cardiomyocyte differentiation and atrial rhythm. Disease models & mechanisms. 6(2):332-341
Wang, W.D., Melville, D.B., Montero-Balaguer, M., Hatzopoulos, A.K., and Knapik, E.W. (2011) Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population. Developmental Biology. 360(1):173-85
Melville, D.B., Montero-Balaguer, M., Levic, D.S., Bradley, K., Smith, J.R., Hatzopoulos, A.K., and Knapik, E.W. (2011) The feelgood mutation in zebrafish dysregulates COPII-dependent secretion of select extracellular matrix proteins in skeletal morphogenesis. Disease models & mechanisms. 4(6):763-76
Eames, B.F., Yan, Y.L., Swartz, M.E., Levic, D.S., Knapik, E.W., Postlethwait, J.H., and Kimmel, C.B. (2011) Mutations in fam20b and xylt1 Reveal That Cartilage Matrix Controls Timing of Endochondral Ossification by Inhibiting Chondrocyte Maturation. PLoS Genetics. 7(8):e1002246
Liu, D., Wang, W.D., Melville, D.B., Cha, Y.I., Yin, Z., Issaeva, N., Knapik, E.W., and Yarbrough, W.G. (2011) Tumor suppressor Lzap regulates cell cycle progression, doming, and zebrafish epiboly. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(6):1613-1625
Bradley, K.M., Breyer, J.P., Melville, D.B., Broman, K.W., Knapik, E.W., and Smith, J.R. (2011) An SNP-Based Linkage Map for Zebrafish Reveals Sex Determination Loci. G3 (Bethesda). 1(1):3-9
Melville, D.B., and Knapik, E.W. (2011) Traffic jams in fish bones: ER-to-Golgi protein transport during zebrafish development. Cell adhesion & migration. 5(2):114-118
Sarmah, S., Barrallo-Gimeno, A., Melville, D.B., Topczewski, J., Solnica-Krezel, L., and Knapik, E.W. (2010) Sec24D-dependent transport of extracellular matrix proteins is required for zebrafish skeletal morphogenesis. PLoS One. 5(4):e10367
Kucenas, S., Wang, W.D., Knapik, E.W., and Appel, B. (2009) A selective glial barrier at motor axon exit points prevents oligodendrocyte migration from the spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(48):15187-15194
Granero-Moltó, F., Sarmah, S., O'Rear, L., Spagnoli, A., Abrahamson, D., Saus, J., Hudson, B.G., and Knapik, E.W. (2008) Goodpasture antigen-binding protein and its spliced variant, ceramide transfer protein, have different functions in the modulation of apoptosis during zebrafish development. The Journal of biological chemistry. 283(29):20495-20504
Bradley, K.M., Elmore, J.B., Breyer, J.P., Yaspan, B.L., Jessen, J.R., Knapik, E.W., and Smith, J.R. (2007) A major zebrafish polymorphism resource for genetic mapping. Genome biology. 8(4):R55
Montero-Balaguer, M., Lang, M.R., Sachdev, S.W., Knappmeyer, C., Stewart, R.A., De La Guardia, A., Hatzopoulos, A.K., and Knapik, E.W. (2006) The mother superior mutation ablates foxd3 activity in neural crest progenitor cells and depletes neural crest derivatives in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(12):3199-3212
Muller, I.I., Knapik, E.W., and Hatzopoulos, A.K. (2006) Expression of the protein related to Dan and Cerberus gene—prdc—During eye, pharyngeal arch, somite, and swim bladder development in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(10):2881-2888
Lang, M.R., Lapierre, L.A., Frotscher, M., Goldenring, J.R., and Knapik, E.W. (2006) Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation. Nature Genetics. 38(10):1198-1203
Barrallo Gimeno, A., Holzschuh, J., Driever, W., and Knapik, E.W. (2004) Neural crest survival and differentiation in zebrafish depends on mont blanc/tfap2a gene function. Development (Cambridge, England). 131(7):1463-1477
Holzschuh, J., Barrallo Gimeno, A., Ettl, A.K., Durr, K., Knapik, E.W., and Driever, W. (2003) Noradrenergic neurons in the zebrafish hindbrain are induced by retinoic acid and require tfap2a for expression of the neurotransmitter phenotype. Development (Cambridge, England). 130(23):5741-5754
Dethleffsen, K., Heinrich, G., Lauth, M., Knapik, E.W., and Meyer, M. (2003) Insert-containing neurotrophins in teleost fish and their relationship to nerve growth factor. Molecular and cellular neurosciences. 24(2):380-394
Sachdev, S.W. and Knapik, E.W. (2001) Positional cloning and characterization of mother superior, a mutation affecting the layout of the pharyngeal skeleton. Molecular biology of the cell. (Suppl.) 12:2020
Sachdev, S.W., Dietz, U.H., Oshima, Y., Lang, M.R., Knapik, E.W., Hiraki, Y., and Shukunami, C. (2001) Sequence analysis of zebrafish chondromodulin-1 and expression profile in the notochord and chondrogenic regions during cartilage morphogenesis. Mechanisms of Development. 105(1-2):157-162
Knapik, E.W. (2000) ENU mutagenesis in zebrafish - from genes to complex diseases. Mammalian genome : official journal of the International Mammalian Genome Society. 11(7):511-519
Chevrette, M., Joly, L., Tellis, P., Knapik, E.W., Miles, J., Fishman, M., and Ekker, M. (2000) Characterization of a zebrafish/mouse somatic cell hybrid panel. Genomics. 64(1):119-26
Shimoda, N., Knapik, E.W., Ziniti, J., Sim, C., Yamada, E., Kaplan, S., Jackson, D., de Sauvage, F., Jacob, H., and Fishman, M.C. (1999) Zebrafish genetic map with 2000 microsatellite markers. Genomics. 58(3):219-232
Förnzler, D., Her, H., Knapik, E.W., Clark, M., Lehrach, H., Postlethwait, J.H., Zon, L.I., Beier, D.R. (1998) Gene mapping in zebrafish using single-strand conformation polymorphism analysis. Genomics. 51:216-222
Postlethwait, J.H, Yan, Y.-L., Gates, M.A., Horne, S., Amores, A., Brownlie, A., Donovan, A., Egan, E.S., Force, A., Gong, Z., Goutel, C., Fritz, A., Kelsh, R., Knapik, E., Liao, E., Paw, B., Ransom, D., Singer, A., Thomson, M., Abduljabbar, T.S., Yelick, P., Beier, D., Joly, J.-S., Larhammar, D., Rosa, F., Westerfield, M., Zon, L.I., Johnson, S.L., and Talbot, W.S. (1998) Vertebrate genome evolution and the zebrafish gene map. Nature Genetics. 18:345-349
Knapik, E.W., Goodman, A., Ekker, M., Chevrette, M., Delgado, J., Neuhauss, S., Shimoda, N., Driever, W., Fishman, M.C., and Jacob, H.J. (1998) A microsatellite genetic linkage map for zebrafish (Danio rerio). Nature Genetics. 18:338-343
Knapik, E.W., Goodman, A., Atkinson, O.S., Roberts, C.T., Shiozawa, M., Sim, C.U., Weksler-Zagen, S., Trolliet, M.R., Futrell, C., Innes, B.A., Koike, G., McLaughlin, M., Pierre, L., Simon, J.S., Vilallonga, E., Roy, M., Chiang, P.W., Fishman, M.C., Driever, W., and Jacob, H.J. (1996) A reference cross DNA panel for zebrafish (Danio rerio) anchored with simple sequence length polymorphisms. Development (Cambridge, England). 123:451-460

Neuman T, Keen A, Knapik E, Shain D, Ross M, Nornes HO, Zuber MX (1992) ME1 and GE1: Basic helix-loop-helix transcription factors expressed at high levels in the developing nervous system and in morphogenetically active regions. Euro. J. Neurosci. 5, 311-318

Nornes HO, Dressler GR, Knapik EW, Deutsch U, Gruss P (1990) Spatially and temporally restricted expression of Pax2 during murine neurogenesis. Development 109, 797-809