ZFIN Person: Dalla Valle, Luisa

ZFIN ID: ZDB-PERS-110808-2

ZFIN ID: ZDB-PERS-110808-2

Dalla Valle, Luisa

Email:	luisa.dallavalle@unipd.it
URL:	https://en.didattica.unipd.it/off/docente/981EEE927352EDF305AA4944532603D2
Affiliation:	Dalla Valle Lab
Address:	Department of Biology via U. Bassi 58/B University of Padova Padova, Italy
Country:
Phone:	390498276188
Fax:	390498276199
ORCID ID:	0000-0001-8097-6369

BIOGRAPHY AND RESEARCH INTERESTS

Research interests
Extraglandular steroidogenesis and the roles of steroid receptors in zebrafish development and adult life, with particular attention to glucocorticoid receptor. The roles of the autophagic proteins Ambra1a, Ambra1b and Epg5 on zebrafish development and autophagy. Use of the zebrafish model to study the anti-inflammatory and antioxidant properties of new potential therapeutic molecules.

PUBLICATIONS

Celeghin, R., Risato, G., Beffagna, G., Cason, M., Bueno Marinas, M., Della Barbera, M., Facchinello, N., Giuliodori, A., Brañas Casas, R., Caichiolo, M., Vettori, A., Grisan, E., Rizzo, S., Dalla Valle, L., Argenton, F., Thiene, G., Tiso, N., Pilichou, K., Basso, C. (2023) A novel DSP zebrafish model reveals training- and drug-induced modulation of arrhythmogenic cardiomyopathy phenotypes. Cell death discovery. 9:441441

Fontana, C.M., Terrin, F., Facchinello, N., Meneghetti, G., Dinarello, A., Gambarotto, L., Zuccarotto, A., Caichiolo, M., Brocca, G., Verin, R., Nazio, F., Carnevali, O., Cecconi, F., Bonaldo, P., Dalla Valle, L. (2023) Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction. Biological research. 56:1919

Maradonna, F., Fontana, C.M., Sella, F., Giommi, C., Facchinello, N., Rampazzo, C., Caichiolo, M., Hoseinifar, S.H., Dalla Valle, L., Van Doan, H., Carnevali, O. (2022) A zebrafish HCT116 xenograft model to predict anandamide outcomes on colorectal cancer. Cell Death & Disease. 13:10691069

Zampieri, R.M., Adessi, A., Caldara, F., De Philippis, R., Valle, L.D., La Rocca, N. (2022) In vivo anti-inflammatory and antioxidant effects of microbial polysaccharides extracted from Euganean therapeutic muds. International journal of biological macromolecules. 209(Pt B):1710-1719

Santacà, M., Dadda, M., Dalla Valle, L., Fontana, C., Gjinaj, G., Bisazza, A. (2022) Learning and visual discrimination in newly hatched zebrafish. iScience. 25:104283

Fontana, C.M., Locatello, L., Sabatelli, P., Facchinello, N., Lidron, E., Maradonna, F., Carnevali, O., Rasotto, M.B., Dalla Valle, L. (2022) epg5 knockout leads to the impairment of reproductive success and courtship behaviour in a zebrafish model of autophagy-related diseases. Biomedical journal. 45(2):377-386

Dinarello, A., Tesoriere, A., Martini, P., Fontana, C.M., Volpato, D., Badenetti, L., Terrin, F., Facchinello, N., Romualdi, C., Carnevali, O., Dalla Valle, L., Argenton, F. (2022) Zebrafish Mutant Lines Reveal the Interplay between nr3c1 and nr3c2 in the GC-Dependent Regulation of Gene Transcription. International Journal of Molecular Sciences. 23(5):

Piccione, M., Facchinello, N., Schrenk, S., Gasparella, M., Pathak, S., Ammar, R.M., Rabini, S., Dalla Valle, L., Di Liddo, R. (2021) STW 5 Herbal Preparation Modulates Wnt3a and Claudin 1 Gene Expression in Zebrafish IBS-like Model. Pharmaceuticals (Basel, Switzerland). 14(12):

Theodoridi, A., Dinarello, A., Badenetti, L., Pavlidis, M., Dalla Valle, L., Tsalafouta, A. (2021) Knockout of the hsd11b2 Gene Extends the Cortisol Stress Response in Both Zebrafish Larvae and Adults. International Journal of Molecular Sciences. 22(22):

Facchinello, N., Laquatra, C., Locatello, L., Beffagna, G., Brañas Casas, R., Fornetto, C., Dinarello, A., Martorano, L., Vettori, A., Risato, G., Celeghin, R., Meneghetti, G., Santoro, M.M., Delahodde, A., Vanzi, F., Rasola, A., Dalla Valle, L., Rasotto, M.B., Lodi, T., Baruffini, E., Argenton, F., Tiso, N. (2021) Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish. Cell Death & Disease. 12:100

Dinarello, A., Licciardello, G., Fontana, C.M., Tiso, N., Argenton, F., Dalla Valle, L. (2020) Glucocorticoid receptor activities in the zebrafish model: a review. The Journal of endocrinology. 247:R63-R82

Maradonna, F., Gioacchini, G., Notarstefano, V., Fontana, C.M., Citton, F., Dalla Valle, L., Giorgini, E., Carnevali, O. (2020) Knockout of the Glucocorticoid Receptor Impairs Reproduction in Female Zebrafish. International Journal of Molecular Sciences. 21(23):

Bruzzone, M., Gatto, E., Lucon Xiccato, T., Dalla Valle, L., Fontana, C.M., Meneghetti, G., Bisazza, A. (2020) Measuring recognition memory in zebrafish larvae: issues and limitations. PeerJ. 8:e8890

Zampieri, R.M., Adessi, A., Caldara, F., Codato, A., Furlan, M., Rampazzo, C., De Philippis, R., La Rocca, N., Dalla Valle, L. (2020) Anti-Inflammatory Activity of Exopolysaccharides from Phormidium sp. ETS05, the Most Abundant Cyanobacterium of the Therapeutic Euganean Thermal Muds, Using the Zebrafish Model. Biomolecules. 10(4):

Morbiato, E., Frigato, E., Dinarello, A., Maradonna, F., Facchinello, N., Argenton, F., Carnevali, O., Dalla Valle, L., Bertolucci, C. (2019) Feeding Entrainment of the Zebrafish Circadian Clock Is Regulated by the Glucocorticoid Receptor. Cells. 8(11):

D'Acunzo, P., Strappazzon, F., Caruana, I., Meneghetti, G., Di Rita, A., Simula, L., Weber, G., Del Bufalo, F., Dalla Valle, L., Campello, S., Locatelli, F., Cecconi, F. (2019) Reversible induction of mitophagy by an optogenetic bimodular system. Nature communications. 10:1533

Meneghetti, G., Skobo, T., Chrisam, M., Facchinello, N., Fontana, C.M., Bellesso, S., Sabatelli, P., Raggi, F., Cecconi, F., Bonaldo, P., Dalla Valle, L. (2019) The epg5 knockout zebrafish line: a model to study Vici syndrome. Autophagy. 15(8):1438-1454

Facchinello, N., Skobo, T., Meneghetti, G., Colletti, E., Dinarello, A., Tiso, N., Costa, R., Gioacchini, G., Carnevali, O., Argenton, F., Colombo, L., Dalla Valle, L. (2017) nr3c1 null mutant zebrafish are viable and reveal DNA-binding-independent activities of the glucocorticoid receptor. Scientific Reports. 7:4371

Santangeli, S., Maradonna, F., Gioacchini, G., Cobellis, G., Piccinetti, C.C., Dalla Valle, L., Carnevali, O. (2016) BPA-Induced Deregulation Of Epigenetic Patterns: Effects On Female Zebrafish Reproduction. Scientific Reports. 6:21982

Cianfanelli, V., Fuoco, C., Lorente, M., Salazar, M., Quondamatteo, F., Gherardini, P.F., De Zio, D., Nazio, F., Antonioli, M., D'Orazio, M., Skobo, T., Bordi, M., Rohde, M., Dalla Valle, L., Helmer-Citterich, M., Gretzmeier, C., Dengjel, J., Fimia, G.M., Piacentini, M., Di Bartolomeo, S., Velasco, G., Cecconi, F. (2015) AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation. Nature cell biology. 17:20-30

Benato, F., Colletti, E., Skobo, T., Moro, E., Colombo, L., Argenton, F., Dalla Valle, L. (2014) A living biosensor model to dynamically trace glucocorticoid transcriptional activity during development and adult life in zebrafish. Molecular and Cellular Endocrinology. 392(1-2):60-72

Benato, F., Skobo, T., Gioacchini, G., Moro, I., Ciccosanti, F., Piacentini, M., Fimia, G.M., Carnevali, O., and Dalla Valle, L. (2013) Ambra1 knockdown in zebrafish leads to incomplete development due to severe defects in organogenesis. Autophagy. 9(4):476-495

Pikulkaew, S., Benato, F., Celeghin, A., Zucal, C., Skobo, T., Colombo, L., and Dalla Valle , L. (2011) The knockdown of maternal glucocorticoid receptor mRNA alters embryo development in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 240(4):874-889

Pikulkaew, S., De Nadai, A., Belvedere, P., Colombo, L., and Dalla Valle, L. (2010) Expression analysis of steroid hormone receptor mRNAs during zebrafish embryogenesis. General and comparative endocrinology. 165(2):215-220

Vianello, S., Brazzoduro, L., Dalla Valle, L., Belvedere, P., and Colombo, L. (2003) Myostatin expression during development and chronic stress in zebrafish (Danio rerio). The Journal of endocrinology. 176(1):47-59

NON-ZEBRAFISH PUBLICATIONS
Holthaus KB, Eckhart L, Dalla Valle L, Alibardi L. 2018. Review: Evolution and diversification of corneous beta-proteins, the characteristic epidermal proteins of reptiles and birds. J. Exp. Zool. B Mol. Dev. Evol., 330, 438-453.
Candelma M, Dalla Valle L, Colella S, Santojanni A, Carnevali O. 2018. Cloning, characterization, and molecular expression of gonadotropin receptors in European hake (Merluccius merluccius), a multiple-spawning species. Fish Physiol. Biochem., 44, 895-910.
Miccoli A, Dalla Valle L, Carnevali O 2017. The maternal control in the embryonic development of zebrafish. Gen. Comp. Endocrinol., 245, 55-68.
Alibardi L, Michieli F, Dalla Valle L 2017. Low-cysteine alpha-keratins and corneous beta proteins are initially formed in the regenerating tail epidermis of lizard. J. Morphol., 278:119–130.
Vitulo N, Dalla Valle L, Skobo T, Valle G, Alibardi L 2017. Transcriptome analysis of the regenerating tail vs. the scarring limb in lizard reveals pathways leading to successful vs. unsuccessful organ regeneration in amniotes. Dev. Dyn., 246, 116-134.
Vitulo N, Dalla Valle L, Skobo T, Valle G, Alibardi L. 2017. Down-regulation of lizard immuno-genes in the regenerating tail and myo-genes in the scarring limb suggests that tail regeneration occurs in an immuno-privileged organ. Protoplasma.
Gasparini F, Skobo T, Benato F, Gioacchini G, Voskoboynik A, Carnevali O, Manni L, Dalla Valle L 2016. Characterization of Ambra1 in asexual cycle of a non-vertebrate chordate, the colonial tunicate Botryllus schlosseri, and phylogenetic analysis of the protein group in Bilateria. Mol. Phylogenetic. Evol., 95, 46-57.
Klionsky DJ et al, 2016 Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy, 12, 1-222.
Pomari E, Dalla Valle L, Pertile P, Colombo L, Thornton MJ 2015. Intracrine sex steroid synthesis and signaling in human epidermal keratinocytes and dermal fibroblasts. Faseb J., 29(2), 508-524.
Maradonna F, Nozzi V, Dalla Valle L, Traversi I, Gioacchini G, Benato F, Colletti E, Gallo P, Di Marco Pisciottano I, Mita DG, Hardiman G, Mandich A, Carnevali O 2014. A developmental hepatotoxicity study of dietary bisphenol A in Sparus aurata juveniles. Comp. Biochem. Physiol. C Toxicol, Pharmacol., 166:1-13.
Dalla Valle L, Michieli F, Benato F, Skobo T, Alibardi L 2013. Molecular characterization of alpha-keratins in comparison to associated beta-proteins in soft-shelled and hard-shelled turtles produced during the process of epidermal differentiation. J. Exp. Zool. B Mol. Dev. Evol., 320(7):428-441.
Dalla Valle L, Benato F, Paccanaro MC, Alibardi L 2013. Bioinformatic and molecular characterization of cathelicidin-like peptides isolated from the green lizard Anolis carolinensis (Reptilia: Lepidosauria: Iguanidae). Ital. J. Zool., 80, 177-186.
Alibardi L, Celeghin A, Dalla Valle L 2012. Wounding in lizards results in the release of beta-defense at the wound site and formation of an antimicrobial barrier. Dev. Comp. Immunol., 36(3), 557-565.
Alibardi L., Segalla A, Dalla Valle L 2012. Distribution of specific keratin-associated beta-proteins (beta-keratins) in the epidermis of the lizard Anolis carolinensis helps to clarify the process of cornification in lepidosaurians. J. Exp. Zool. B Mol. Dev. Evol., 318(5), 388-403.
Benato F, Dalla Valle L, Skobo T, Alibardi L 2013. Biomolecular identification of beta-defensin-like peptides from the skin of the soft-shelled turtle Apalone spinifera. J. Exp. Zool. B Mol. Dev. Evol., 320(4):210-7.
Dalla Valle L., Benato F., Maistro S., Quinzani S., Alibardi L. (2012). Bioinformatic and molecular characterization of beta-defensins-like peptides isolated from the green lizard anolis carolinensis. Dev. Comp. Immunol., 36, 222-229.
Dalla Valle L., Nardi A., Gelmi C., Toni M., Emera D., Alibardi L. (2009). Beta-keratins of the crocodilian epidermis: composition, structure, and phylogenetic relationships. J. Exp. Zool. B Mol. Dev. Evol., 312:42-57.
Dalla Valle L., Nardi A., Toni M., Emera D., Alibardi L. (2009). Beta-keratins of turtle shell are glycine-proline-tyrosine rich proteins similar to those of crocodilians and birds. Journal of Anatomy, 214, 284-300.
Eckhart L., Dalla Valle L., Jaeger K., Ballaun C., Szabo S., Nardi A., Buchberger M., Hermann M., Alibardi L., Tschachler E. (2008). Identification of reptilian genes encoding hair keratin-like proteins suggests a new scenario for the evolutionary origin of hair. PNAS, 105(47):18419-23.
Dalla Valle L., Toffolo V., Nardi A., Fiore C., Bernante P., Di Liddo R., Parnigotto P.P., Colombo L. (2006). Tissue-specific transcriptional initiation and activity of steroid sulfatase complementing dehydroepiandrosterone sulfate uptake and intracrine steroid activations in human adipose tissue. J. Endocrinol., 190, 129-139.
Dalla Valle L., Toffolo V., Belvedere P., Alibardi L. (2005). Isolation of a mRNA encoding a glycine-proline-rich β-keratin expressed in the regenerating epidermis of lizard. Dev Dyn., 234(4), 934-947.
Dalla Valle L., Toffolo V., Vianello S., Belvedere P., Colombo L. (2004). Expression of cytochrome P450scc mRNA and protein in the rat kidney from birth to adulthood. J. Steroid Biochem. Mol. Biol., 88(1), 79-89.
Dalla Valle L., Ramina A., Vianello S., Belvedere P., Colombo L. (2002). Cloning of two mRNA variants of brain aromatase cytochrome P450 in rainbow trout (Oncorhynchus mykiss Walbaum). J. Steroid Biochem. Mol. Biol., 82 (1), 19-32.
Dalla Valle L., Ramina A., Vianello S., Fassina A., Belvedere P., Colombo L. (1998). Potential for estrogen synthesis and action in human normal and neoplastic thyroid tissues. J. Clin. Endocrinol. Metab., 83, 3702-3709.
Vianello S., Waterman M.R., Dalla Valle L., Colombo L. (1997). Developmentally regulated expression and activity of 17α-hydroxylase/C-17,20 lyase cytochrome P450 (P450c17) in rat liver. Endocrinology, 138, 3166-3174.
Dalla Valle L., Couet J., Simard J., Labrie Y., Belvedere P., Simontacchi C., Labrie F., Colombo L. (1995). Occurrence of cytochrome P-450c17 and androgen biosynthesis in the oesophagus and gastrointestinal tract of the rat. Mol. Cell. Endocrinol., 111, 83-92.