ZFIN ID: ZDB-PERS-110112-2
Zhang, Bo
Email: bzhang@pku.edu.cn
Affiliation: PKU Zebrafish Functional Genomics Group
Address: No 5 YiHeYuan Rd. Haidian District College of Life Sciences Peking University Beijing, 100871 China
Country: China
Phone: 86-10-62759072


Niu, X., Zhang, F., Gu, W., Zhang, B., Chen, X. (2024) FBLN2 is associated with Goldenhar syndrome and is essential for cranial neural crest cell development. Annals of the New York Academy of Sciences. 1537(1):113-128
Song, W., Xia, X., Fan, Y., Zhang, B., Chen, X. (2024) Functional and Genetic Analyses Unveil the Implication of CDC27 in Hemifacial Microsomia. International Journal of Molecular Sciences. 25(9):
Sun, L., Ping, L., Fan, X., Fan, Y., Zhang, B., Chen, X. (2024) amer1 Regulates Zebrafish Craniofacial Development by Interacting with the Wnt/β-Catenin Pathway. International Journal of Molecular Sciences. 25(2):
Sun, L., Ping, L., Gao, R., Zhang, B., Chen, X. (2023) lmo4a Contributes to Zebrafish Inner Ear and Vestibular Development via Regulation of the Bmp Pathway. Genes. 14(7):
Wu, Z., Shi, Y., Cui, Y., Xing, X., Zhang, L., Liu, D., Zhang, Y., Dong, J., Jin, L., Pang, M., Xiao, R.P., Zhu, Z., Xiong, J.W., Tong, X., Zhang, Y., Wang, S., Tang, F., Zhang, B. (2023) Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration. Protein & cell. 14:350368350-368
Niu, X., Zhang, F., Ping, L., Wang, Y., Zhang, B., Wang, J., Chen, X. (2023) vwa1 Knockout in Zebrafish Causes Abnormal Craniofacial Chondrogenesis by Regulating FGF Pathway. Genes. 14(4):
Han, B., Zhang, Y., Zhou, Y., Zhang, B., Krueger, C.J., Bi, X., Zhu, Z., Tong, X., Zhang, B. (2022) ErCas12a and T5exo-ErCas12a Mediate Simple and Efficient Genome Editing in Zebrafish. Biology. 11(3):
Li, T., Wang, Y., Li, D., Zhou, J., Zhang, B., He, X. (2021) Potential role for the tumor suppressor CYLD in brain and notochord development. Thoracic cancer. 12(12):1900-1908
Lu, J., Cheng, C., Cheng, Z.C., Wu, Q., Shen, H., Yuan, M.X., Zhang, B., Yang, J.K. (2020) The dual role of RFX6 in directing β cell development and insulin production. Journal of molecular endocrinology. 66(2):129-140
Wang, Y., Ping, L., Luan, X., Chen, Y., Fan, X., Li, L., Liu, Y., Wang, P., Zhang, S., Zhang, B., Chen, X. (2020) A Mutation in VWA1, Encoding von Willebrand Factor A Domain-Containing Protein 1, Is Associated With Hemifacial Microsomia. Frontiers in cell and developmental biology. 8:571004
Han, B., Zhang, Y., Bi, X., Zhou, Y., Krueger, C.J., Hu, X., Zhu, Z., Tong, X., Zhang, B. (2020) Bi-FoRe: an efficient bidirectional knockin strategy to generate pairwise conditional alleles with fluorescent indicators. Protein & cell. 12(1):39-56
Pang, L., Zhang, Z., Shen, Y., Cheng, Z., Gao, X., Zhang, B., Wang, X., Tian, H. (2020) Mutant dlx3b disturbs normal tooth mineralization and bone formation in zebrafish. PeerJ. 8:e8515
Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
Wang, L., Ren, A., Tian, T., Li, N., Cao, X., Zhang, P., Jin, L., Li, Z., Shen, Y., Zhang, B., Finnell, R.H., Lei, Y. (2019) Whole-Exome Sequencing Identifies Damaging de novo Variants in Anencephalic Cases. Frontiers in neuroscience. 13:1285
Li, W., Zhang, Y., Han, B., Li, L., Li, M., Lu, X., Chen, C., Lu, M., Zhang, Y., Jia, X., Zhu, Z., Tong, X., Zhang, B. (2019) One-step efficient generation of dual-function conditional knockout and geno-tagging alleles in zebrafish. eLIFE. 8:
Lu, C.J., Fan, X.Y., Guo, Y.F., Cheng, Z.C., Dong, J., Chen, J.Z., Li, L.Y., Wang, M.W., Wu, Z.K., Wang, F., Tong, X.J., Luo, L.F., Tang, F.C., Zhu, Z.Y., Zhang, B. (2018) Single-cell analyses identify distinct and intermediate states of zebrafish pancreatic islet development. Journal of molecular cell biology. 11(6):435-447
Wang, K., Zhao, S., Liu, B., Zhang, Q., Li, Y., Liu, J., Shen, Y., Ding, X., Lin, J., Wu, Y., Yan, Z., Chen, J., Li, X., Song, X., Niu, Y., Liu, J., Chen, W., Ming, Y., Du, R., Chen, C., Long, B., Zhang, Y., Tong, X., Zhang, S., Posey, J.E., Zhang, B., Wu, Z., Wythe, J.D., Liu, P., Lupski, J.R., Yang, X., Wu, N. (2018) Perturbations of BMP/TGF-β and VEGF/VEGFR signalling pathways in non-syndromic sporadic brain arteriovenous malformations (BAVM). Journal of Medical Genetics. 55(10):675-684
Tian, T., Wang, L., Shen, Y., Zhang, B., Finnell, R.H., Ren, A. (2018) Hypomethylation of GRHL3 gene is associated with the occurrence of neural tube defects. Epigenomics. 10(7):891-901
Yan, Q., Zhai, L., Zhang, B., Dallman, J.E. (2017) Spatial patterning of excitatory and inhibitory neuropil territories during spinal circuit development. The Journal of comparative neurology. 525(7):1649-1667
Zhao, J., Xu, T., Yin, D., Zhang, B., Bai, J. (2017) The Regulatory Roles of MicroRNA in Effects of 2,2'4,4'-Tetrabromodiphenyl Ether (BDE47) on the Transcriptome of Zebrafish Larvae. PLoS One. 12:e0169599
Zhang, J., Wang, C., Shen, Y., Chen, N., Wang, L., Liang, L., Guo, T., Yin, X., Ma, Z., Zhang, B., Yang, L. (2016) A mutation in ADIPOR1 causes nonsyndromic autosomal dominant retinitis pigmentosa. Human genetics. 135(12):1375-1387
Li, W., Zheng, N.Z., Yuan, Q., Xu, K., Yang, F., Gu, L., Zheng, G.Y., Luo, G.J., Fan, C., Ji, G.J., Zhang, B., Cao, H., Tian, X.L. (2016) NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation. Journal of molecular medicine (Berlin, Germany). 94(9):993-1002
Cox, J.A., Zhang, B., Pope, H.M., Voigt, M.M. (2016) Transcriptome Analysis of Chemically-Induced Sensory Neuron Ablation in Zebrafish. PLoS One. 11:e0148726
Tao, X., Li, C., Zhang, B., He, Y. (2016) Effects of aqueous stable fullerene nanocrystals (nC60) on the food conversion from Daphnia magna to Danio rerio in a simplified freshwater food chain. Chemosphere. 145:157-162
Xiao, A., Zhang, B. (2016) Generation of Targeted Genomic Deletions Through CRISPR/Cas System in Zebrafish. Methods in molecular biology (Clifton, N.J.). 1451:65-79
Huang, P., Xiao, A., Tong, X., Lin, S., Zhang, B. (2016) Targeted Mutagenesis in Zebrafish by TALENs. Methods in molecular biology (Clifton, N.J.). 1338:191-206
Zhang, Y., Huang, H., Zhang, B., Lin, S. (2016) TALEN- and CRISPR-enhanced DNA homologous recombination for gene editing in zebrafish. Methods in cell biology. 135:107-20
Liu, H.J., Zhang, C.Y., Song, F., Xiao, T., Meng, J., Zhang, Q., Liang, C.L., Li, S., Wang, J., Zhang, B., Liu, Y.R., Sun, T., Zhou, H.G. (2015) A Novel Partial Agonist of Peroxisome Proliferator-Activated Receptor γ with Excellent Effect on Insulin Resistance and Type 2 Diabetes. The Journal of pharmacology and experimental therapeutics. 353:573-81
Lee, H.J., Lowdon, R.F., Maricque, B., Zhang, B., Stevens, M., Li, D., Johnson, S.L., Wang, T. (2015) Developmental enhancers revealed by extensive DNA methylome maps of zebrafish early embryos. Nature communications. 6:6315
Hüsken, U., Stickney, H.L., Gestri, G., Bianco, I.H., Faro, A., Young, R.M., Roussigne, M., Hawkins, T.A., Beretta, C.A., Brinkmann, I., Paolini, A., Jacinto, R., Albadri, S., Dreosti, E., Tsalavouta, M., Schwarz, Q., Cavodeassi, F., Barth, A.K., Wen, L., Zhang, B., Blader, P., Yaksi, E., Poggi, L., Zigman, M., Lin, S., Wilson, S.W., Carl, M. (2014) Tcf7l2 Is Required for Left-Right Asymmetric Differentiation of Habenular Neurons. Current biology : CB. 24(19):2217-27
Huang, P., Xiao, A., Tong, X., Zu, Y., Wang, Z., Zhang, B. (2014) TALEN construction via "Unit Assembly" method and targeted genome modifications in zebrafish. Methods (San Diego, Calif.). 69(1):67-75
Zhang, Y., Ear, J., Yang, Z., Morimoto, K., Zhang, B., Lin, S. (2014) Defects of protein production in erythroid cells revealed in a zebrafish Diamond-Blackfan anemia model for mutation in RPS19. Cell Death & Disease. 5:e1352
Zheng, C., Zhou, H., Liu, X., Pang, Y., Zhang, B., and Huang, Y. (2014) Fish in chips: an automated microfluidic device to study drug dynamics in vivo using zebrafish embryos. Chemical communications (Cambridge, England). 50(8):981-984
Liu, D., Wang, Z., Xiao, A., Zhang, Y., Li, W., Zu, Y., Yao, S., Lin, S., and Zhang, B. (2014) Efficient gene targeting in zebrafish mediated by a zebrafish-codon-optimized cas9 and evaluation of off-targeting effect. Journal of genetics and genomics = Yi chuan xue bao. 41(1):43-46
Tong, X., Zu, Y., Li, Z., Li, W., Ying, L., Yang, J., Wang, X., He, S., Liu, D., Zhu, Z., Chen, J., Lin, S., and Zhang, B. (2014) Kctd10 regulates heart morphogenesis by repressing the transcriptional activity of Tbx5a in zebrafish. Nature communications. 5:3153
Xia, Z., Tong, X., Liang, F., Zhang, Y., Kuok, C., Zhang, Y., Liu, X., Zhu, Z., Lin, S., and Zhang, B. (2013) Eif3ba regulates cranial neural crest development by modulating p53 in zebrafish. Developmental Biology. 381(1):83-96
Xiao, A., Wang, Z., Hu, Y., Wu, Y., Luo, Z., Yang, Z., Zu, Y., Li, W., Huang, P., Tong, X., Zhu, Z., Lin, S., and Zhang, B. (2013) Chromosomal deletions and inversions mediated by TALENs and CRISPR/Cas in zebrafish. Nucleic acids research. 41(14):e141
Wang, L., Liu, T., Xu, L., Gao, Y., Wei, Y., Duan, C., Chen, G.Q., Lin, S., Patient, R., Zhang, B., Hong, D., and Liu, F. (2013) Fev regulates hematopoietic stem cell development via ERK signaling. Blood. 122(3):367-75
Jiang, L., Zhang, J., Wang, J.J., Wang, L., Zhang, L., Li, G., Yang, X., Ma, X., Sun, X., Cai, J., Zhang, J., Huang, X., Yu, M., Wang, X., Liu, F., Wu, C.I., He, C., Zhang, B., Ci, W., and Liu, J. (2013) Sperm, but not oocyte, DNA methylome is inherited by zebrafish early embryos. Cell. 153(4):773-784
Shen, Y., Huang, P., and Zhang, B. (2013) A protocol for TALEN construction and gene targeting in zebrafish. Yi chuan = Hereditas. 35(4):533-544
Liu, X.X., Zhang, Y.T., and Zhang, B. (2013) A surgery protocol to construct zebrafish heart damage and regeneration model. Yi chuan = Hereditas. 35(4):529-532
Shen, Y., Xiao, A., Huang, P., Wang, W.Y., Zhu, Z.Y., and Zhang, B. (2013) TALE nuclease engineering and targeted genome modification. Yi chuan = Hereditas. 35(4):395-409
Zu, Y., Tong, X., Wang, Z., Liu, D., Pan, R., Li, Z., Hu, Y., Luo, Z., Huang, P., Wu, Q., Zhu, Z., Zhang, B., and Lin, S. (2013) TALEN-mediated precise genome modification by homologous recombination in zebrafish. Nature Methods. 10(4):329-31
Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
Tong, X., Xia, Z., Zu, Y., Telfer, H., Hu, J., Yu, J., Liu, H., Zhang, Q., Sodmergen, D., Lin, S., and Zhang, B. (2013) Ngs (notochord granular surface) encodes a novel type of intermediate filament family protein essential for notochord maintenance in zebrafish. The Journal of biological chemistry. 288(4):2711-2720
Huang, P., Xu, L., Liang, W., Tam, C.I., Zhang, Y., Qi, F., Zhu, Z., Lin, S., and Zhang, B. (2013) Genomic deletion induced by Tol2 transposon excision in zebrafish. Nucleic acids research. 41(2):e36
Huang, P., Zhu, Z., Lin, S., and Zhang, B. (2012) Reverse genetic approaches in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 39(9):421-433
Mu, Y., Li, X.Q., Zhang, B., and Du, J.L. (2012) Visual Input Modulates Audiomotor Function via Hypothalamic Dopaminergic Neurons through a Cooperative Mechanism. Neuron. 75(4):688-699
Dong, W., Yang, Z., Yang, F., Wang, J., Zhuang, Y., Xu, C., Zhang, B., Tian, X.L., and Liu, D. (2012) Suppression of rap1 impairs cardiac myofibrils and conduction system in zebrafish. PLoS One. 7(11):e50960
Zhang, Y., Morimoto, K., Danilova, N., Zhang, B., and Lin, S. (2012) Zebrafish Models for Dyskeratosis Congenita Reveal Critical Roles of p53 Activation Contributing to Hematopoietic Defects through RNA Processing. PLoS One. 7(1):e30188
Huang, P., Xiao, A., Zhou, M., Zhu, Z., Lin, S., and Zhang, B. (2011) Heritable gene targeting in zebrafish using customized TALENs. Nat. Biotechnol.. 29(8):699-700
Gao, W., Xu, L., Guan, R., Liu, X., Han, Y., Wu, Q., Xiao, Y., Qi, F., Zhu, Z., Lin, S., and Zhang, B. (2011) Wdr18 Is Required for Kupffer's Vesicle Formation and Regulation of Body Asymmetry in Zebrafish. PLoS One. 6(8):e23386
Wen, L., Wei, W., Gu, W., Huang, P., Ren, X., Zhang, Z., Zhu, Z., Lin, S., and Zhang, B. (2008) Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish. Developmental Biology. 314(1):84-92