ZFIN Gene: lcp1

ZFIN ID: ZDB-GENE-991213-5

ZFIN ID: ZDB-GENE-991213-5

Gene Name:

lymphocyte cytosolic protein 1 (L-plastin)

Gene Symbol:

lcp1 Nomenclature History

Previous Names:

cb245 (1), fj24b12, l plastin, L-plastin (1), leucocyte-specific plastin, wu:fj24b12

Gene Type:

protein_coding_gene

Location:

Chr: 9 Mapping Details/Browsers

Description:

Predicted to have actin filament binding activity. Predicted to be involved in actin filament bundle assembly and actin filament network formation. Localizes to cytoplasm. Is expressed in several structures, including eye; hematopoietic cell; hematopoietic system; mesoderm; and renal system. Orthologous to human LCP1 (lymphocyte cytosolic protein 1).

Genome Resources:

Alliance (1), Gene:30583 (1), Ensembl(GRCz11):ENSDARG00000023188 (2)

GENE EXPRESSION
All Expression Data:	192 figures from 142 publications
Directly Submitted Expression Data:	6 figures (10 images) from Thisse et al., 2001 [cb245]
Wild-type Stages, Structures:	Gastrula:50%-epiboly (5.25h-5.66h) to Juvenile:Days 45-89 (45d-90d, 14 mm, 12 teeth)
	anterior lateral plate mesoderm ball anterior region blood blood island myeloid cell caudal hematopoietic tissue common myeloid progenitor endoderm EVL eye macrophage granulocyte granulocyte monocyte progenitor cell head macrophage head head kidney myeloid lineage restricted progenitor cell head kidney hematopoietic cell hematopoietic multipotent progenitor cell hematopoietic system posterior region hematopoietic system intermediate cell mass of mesoderm macrophage intermediate cell mass of mesoderm kidney lateral plate mesoderm leukocyte lymphocyte macrophage mesoderm anterior side microglial cell monocyte myeloid cell myeloid leukocyte myeloid lineage restricted progenitor cell neutrophil optic tectum microglial cell periderm post-vent region hematopoietic stem cell post-vent region myeloid cell post-vent region posterior cardinal vein macrophage posterior lateral mesoderm pro-T cell pronephric duct anatomical structure pronephros monocyte pronephros retina macrophage rostral blood island myeloid cell rostral blood island thymus hematopoietic multipotent progenitor cell thymus trunk unspecified ventral wall of dorsal aorta myeloid cell ventral wall of dorsal aorta vitreous macrophage whole organism cell whole organism yolk macrophage yolk syncytial layer myeloid cell
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa45867	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
ud1	Indel	Exon 2	Frameshift, Premature Stop	CRISPR
ud2	Indel	Exon 2	Frameshift, Premature Stop	CRISPR	Zebrafish International Resource Center (ZIRC) (order this)
ud3	Small Deletion	Exon 2	Frameshift, Premature Stop	CRISPR	Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-lcp1	ud1 ud2 ud3	1
CRISPR2-lcp1		1

PHENOTYPE

Data:	3 figures from Kell et al., 2018
Observed in:	leukocyte whole organism

DISEASE ASSOCIATED WITH lcp1 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH lcp1 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	actin filament bundle assembly (more)
Cellular Component	cytoplasm (more)
Molecular Function	actin binding (more)

GO Terms (all 15)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

Browsers: NCBI

INTERACTIONS AND PATHWAYS

ANTIBODIES

Name	Type	Isotype	Host Organism	Assay	Source	Publications
Ab3-lcp1	polyclonal		Rabbit	IHC		7
Ab5-lcp1	polyclonal	IgG	Rabbit	IHC	GeneTex	3
Ab2-lcp1	polyclonal		Rabbit	IHC, WB		39
Ab1-lcp1	polyclonal		Rabbit	IHC		20

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM lcp1

Construct	Regulatory Regions	Coding Sequences	Species	Tg Lines	Publications
Tg(lcp1:Cre-P2A-EGFP-CAAX)	lcp1	2A, CAAX, Cre, EGFP	Danio rerio	1	2

MARKER RELATIONSHIPS

lcp1 Contained in:	[Fosmid] ZFOS-1926B4 (1)
lcp1 Encodes:	[EST] cb245 (1) (order this), fj24b12 [cDNA] MGC:66040 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_131320 (1)	2324 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU914623 (1)	37492 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A140LGK1 (1)	624 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 18)

ORTHOLOGY for lcp1 ( Chr: 9 )

CITATIONS (246)

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