ZFIN ID: ZDB-GENE-991213-5
Gene Name: lymphocyte cytosolic protein 1 (L-plastin)
Gene Symbol: lcp1    Nomenclature History

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Previous Names: cb245 (1), fj24b12, l plastin, L-plastin (1), leucocyte-specific plastin, wu:fj24b12

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity. Predicted to be involved in actin filament bundle assembly and actin filament network formation. Localizes to cytoplasm. Is expressed in several structures, including eye; hematopoietic cell; hematopoietic system; mesoderm; and renal system. Orthologous to human LCP1 (lymphocyte cytosolic protein 1).
Genome Resources: Alliance (1),  Gene:30583 (1),  Ensembl(GRCz11):ENSDARG00000023188 (2)
GENE EXPRESSION
All Expression Data: 192 figures from 142 publications
Directly Submitted Expression Data: 6 figures (10 images) from Thisse et al., 2001 [cb245]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Juvenile:Days 45-89 (45d-90d, 14 mm, 12 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa45867 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ud1 Indel Exon 2 Frameshift, Premature Stop CRISPR
    ud2 Indel Exon 2 Frameshift, Premature Stop CRISPR
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ud3 Small Deletion Exon 2 Frameshift, Premature Stop CRISPR
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-lcp1 1
    CRISPR2-lcp1
    1
    PHENOTYPE
    Data: 3 figures from Kell et al., 2018
    Observed in:
    DISEASE ASSOCIATED WITH lcp1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH lcp1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process actin filament bundle assembly (more)
    Cellular Component cytoplasm (more)
    Molecular Function actin binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab3-lcp1 polyclonal Rabbit IHC 7
    Ab5-lcp1 polyclonal IgG Rabbit IHC GeneTex
    3
    Ab2-lcp1 polyclonal Rabbit IHC, WB 39
    Ab1-lcp1 polyclonal Rabbit IHC 20
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lcp1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(lcp1:Cre-P2A-EGFP-CAAX) lcp1 2ACAAXCreEGFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    lcp1 Contained in: [Fosmid] ZFOS-1926B4 (1)
    lcp1 Encodes: [EST] cb245 (1) (order this), fj24b12
    [cDNA] MGC:66040 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131320 (1) 2324 nt
    Genomic GenBank:CU914623 (1) 37492 nt
    Select Tool
    Polypeptide UniProtKB:A0A140LGK1 (1) 624 aa
    Sequence Information (all 18)
    ORTHOLOGY for lcp1 ( Chr: 9 )
    CITATIONS (246)