ZFIN ID: ZDB-GENE-991207-22
Gene Name: junction plakoglobin a
Gene Symbol: jupa    Nomenclature History

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Previous Names: jup, cb80 (1), danPG, fb11b06, gamma-catenin (1), plakoglobin (1), wu:fb11b06 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have several functions, including alpha-catenin binding activity; cadherin binding activity; and transcription coactivator activity. Involved in atrioventricular valve morphogenesis and negative regulation of Wnt signaling pathway involved in heart development. Localizes to several cellular components, including adherens junction; catenin complex; and desmosome. Is expressed in several structures, including EVL; ectoderm; forerunner cell group; sensory system; and solid lens vesicle. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); palmoplantar keratosis (multiple); renal cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human JUP (junction plakoglobin).
Genome Resources: Alliance (1),  Gene:30415 (1),  Ensembl(GRCz11):ENSDARG00000070787 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ct520aGt Transgenic Insertion Unknown Unknown DNA
la011634Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12692 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12961 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14171 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31818 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-jupa N/A 3
    MO2-jupa N/A 1
    DISEASE ASSOCIATED WITH jupa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    arrhythmogenic right ventricular dysplasia 12 Alliance Arrhythmogenic right ventricular dysplasia 12 611528
    Naxos disease Alliance Naxos disease 601214
    DISEASE ASSOCIATED WITH jupa VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of Wnt signaling pathway involved in heart development (more)
    Cellular Component adherens junction (more)
    Molecular Function alpha-catenin binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA jupa-201 (1)    Ensembl 3272
    ncRNA jupa-002 (1)    Ensembl 771
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-jup monoclonal IgG2a Mouse IHC, WB BD Biosciences
    5
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM jupa
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(her4.1:jupa-EGFP) her4.1 EGFPjupa Danio rerio 1 2
    MARKER RELATIONSHIPS
    jupa Contained in: [BAC] DKEY-8O15 (1) (order this)
    jupa Encodes: [EST] cb80 (1) (order this), fb11b06 (1)
    [cDNA] MGC:55216 (1), MGC:65740 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131177 (1) 3269 nt
    Genomic GenBank:CR848705 (1) 261584 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QDB8 (1) 729 aa
    Sequence Information (all 39)
    ORTHOLOGY for jupa ( Chr: 11 )
    CITATIONS (37)