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Gene

jupa

ID
ZDB-GENE-991207-22
Name
junction plakoglobin a
Symbol
jupa Nomenclature History
Previous Names
  • jup
  • cb80 (1)
  • danPG
  • fb11b06
  • gamma-catenin (1)
  • plakoglobin (1)
  • wu:fb11b06 (1)
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable several functions, including alpha-catenin binding activity; cadherin binding activity; and transcription coactivator activity. Acts upstream of or within atrioventricular valve morphogenesis and negative regulation of Wnt signaling pathway involved in heart development. Located in adherens junction; desmosome; and nucleus. Part of catenin complex. Is expressed in several structures, including EVL; ectoderm; forerunner cell group; sensory system; and solid lens vesicle. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); palmoplantar keratosis (multiple); renal cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human JUP (junction plakoglobin).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
18 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With jupa Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
arrhythmogenic right ventricular dysplasia 12 Alliance ?Arrhythmogenic right ventricular dysplasia 12 611528
Naxos disease Alliance Naxos disease 601214
Associated With jupa Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR013284 Beta-catenin
Family IPR030461 Junction plakoglobin
Homologous_superfamily IPR011989 Armadillo-like helical
Homologous_superfamily IPR016024 Armadillo-type fold
Repeat IPR000225 Armadillo
Domain Details Per Protein
Protein Length Armadillo Armadillo-like helical Armadillo-type fold Beta-catenin Junction plakoglobin
UniProtKB:A0A2R8QDB8 729
UniProtKB:B7ZGY7 415
UniProtKB:Q9PVF7 729
UniProtKB:Q7ZWH9 390
UniProtKB:F1QTT3 729
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-jup monoclonal IgG2a Mouse
  • IHC
  • WB
BD Biosciences
5
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations