ZFIN ID: ZDB-GENE-990914-3
Gene Name: glial fibrillary acidic protein
Gene Symbol: gfap    Nomenclature History

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Previous Names: af506734 (1), cb345 (1), etID36982.3 (1), wu:fb34h11 (1), wu:fk42c12, xx:af506734 (1), zgc:110485, zrf-1 antigen (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have structural molecule activity. Localizes to cytoplasm and type III intermediate filament. Is expressed in several structures, including anterior neural keel; nervous system; neural tube; neuronal stem cell; and optic vesicle. Human ortholog(s) of this gene implicated in Alexander disease. Orthologous to human GFAP (glial fibrillary acidic protein).
Genome Resources: Alliance (1),  Gene:30646 (1),  Ensembl(GRCz11):ENSDARG00000025301 (2)
GENE EXPRESSION
All Expression Data: 84 figures from 54 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2001 [cb345]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cig6Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
ion44Tg Transgenic Insertion Intron 8 Unknown DNA_AND_CRISPR
sa2123 Point Mutation Unknown Premature Stop ENU
sa20045 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33210 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gfap
    1
    CRISPR2-gfap 1
    CRISPR3-gfap 1
    TALEN1-gfap 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gfap HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Alexander disease Alliance Alexander disease 203450
    DISEASE ASSOCIATED WITH gfap VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component cytoplasm (more)
    Molecular Function structural molecule activity (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gfap-201 (1)    Ensembl 2651
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-gfap monoclonal IgG1 Mouse IHC Dako North America, Inc.
    Abcam plc
    MP Biomedicals
    2
    zrf-1 monoclonal IgG1 Mouse IHC Zebrafish International Resource Center (ZIRC)  (order this)
    104
    Ab2-gfap polyclonal Rabbit IHC Dako North America, Inc.
    32
    Ab4-gfap polyclonal Rabbit IHC 6
    CONSTRUCTS WITH SEQUENCES FROM gfap
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Et(gfap:EGFP) gfap EGFP Danio rerio 1 3
    Tg(2.3gfap:GFP) gfap GFP Danio rerio 1 2
    Tg(bcl2b:mCherry,gfap:LOX2272-EGFP) bcl2bgfap EGFPLOX2272mCherry Danio rerio 291 3
    tg(gfap:cochr-egfp) gfap CoChREGFP Danio rerio 1 1
    Tg(gfap:Cre) gfap Cre Danio rerio 1 1
    Tg(gfap:Cre-ERT2,cryaa:YFP) cryaagfap CreERT2YFP Danio rerio 1 1
    Tg(gfap:Eco.GltL-cpEGFP) gfap cpEGFP Danio rerioEscherichia coli 1 2
    Tg(gfap:EGFP) gfap EGFP Danio rerio 1 30
    Tg(gfap:EGFP-2A-FLAG-park7) gfap 2AEGFPFLAGpark7 Danio rerio 1 1
    tg(gfap:egfp-hsa.idh1) gfap EGFP Danio rerioHomo sapiens 1 1
    tg(gfap:egfp-hsa.idh1_g70d) gfap EGFP Danio rerioHomo sapiens 1 1
    tg(gfap:egfp-hsa.idh1_r132c) gfap EGFP Danio rerioHomo sapiens 1 1
    tg(gfap:egfp-hsa.idh1_r132h) gfap EGFP Danio rerioHomo sapiens 1 1
    Tg(gfap:GAL4) gfap GAL4 Danio rerio 1 2
    Tg(gfap:GAL4FF) gfap GAL4FF Danio rerio 3 1
    tg(gfap:gcamp6f) gfap GCaMP Danio rerio 1 1
    Tg(gfap:GFP) gfap GFP Danio rerio 3 132
    tg(gfap:h2b-gcamp6f) gfap GCaMP Danio rerio 1 1
    tg(gfap:jrgeco1b) gfap RGECO Danio rerio 1 2
    Tg(gfap:LEXPR,LEXOP:EGFP) gfap EGFP Danio rerio 1 2
    tg(gfap:mcherry) gfap mCherry Danio rerio 1 1
    Tg(gfap:nGFP) gfap EGFPNLS Danio rerio 1 7
    Tg(gfap:NLS-mCherry) gfap mCherryNLS Danio rerio 1 1
    Tg(gfap:NTR-mCherry) gfap mCherryNTR Danio rerio 2 6
    tg(gfap:opto-a1ar-eyfp) gfap EYFPOpto-a1AR Danio rerio 1 1
    Tg(gfap:RTTA-VP16) gfap RTTAVP16 Danio rerio 1 1
    Tg(gfap:stat3-EGFP) gfap EGFPstat3 Danio rerio 1 5
    tg(gfap:tdtomato) gfap Tomato Danio rerio 1 1
    Tg(gfap:Tomato) gfap Tomato Danio rerio 1 4
    Tg1(gfap:GAL4) gfap GAL4 Danio rerio 0 1
    tg2(gfap:egfp) gfap EGFP Danio rerio 1 1
    tg2(gfap:gal4) gfap GAL4 Danio rerio 1 1
    tg2(gfap:gal4ff) gfap GAL4FF Danio rerio 1 1
    TgBAC(gfap:GAL4FF) gfap GAL4FF Danio rerio 1 4
    TgBAC(gfap:gfap-GFP) gfapGFP Danio rerio 1 12
    MARKER RELATIONSHIPS
    gfap Contained in: [BAC] DKEY-15N1 (1) (order this)
    gfap Contains: [SNP] rs3727711 (1)
    gfap Encodes: [EST] af506734, cb345 (1) (order this), fb34h11 (1), fk42c12 (1)
    [cDNA] MGC:110485 (1), MGC:191386 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131373 (1) 2570 nt
    Genomic GenBank:BX324157 (1) 272769 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B2GP50 (1) 444 aa
    Sequence Information (all 47)
    ORTHOLOGY for gfap ( Chr: 3 )
    CITATIONS (215)