ZFIN ID: ZDB-GENE-990914-3
Gene Name: glial fibrillary acidic protein
Gene Symbol: gfap
Previous Names: af506734 (1), cb345 (1), etID36982.3 (1), wu:fb34h11 (1), wu:fk42c12, xx:af506734 (1), zgc:110485, zrf-1 antigen (1)
Location: Chr: 3 Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 74 figures from 45 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2001 [cb345]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
  alar plate midbrain region, anterior commissure axon, anterior commissure glial cell, anterior commissure glial cell (sensu Vertebrata) (all 54) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Mutagen Suppliers
sa20045 Point Mutation ENU
Targeting reagents: CRISPR1-gfap (1), TALEN1-gfap (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH gfap HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
Alexander disease Alexander disease 203450
GENE ONTOLOGY
Ontology GO Term
Cellular Component cytoplasm (more)
Molecular Function structural molecule activity (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001664 (1)
  • InterPro:IPR002957 (1)
  • InterPro:IPR006821 (1)
  • InterPro:IPR018039 (1)
  • InterPro:IPR027701 (1)
  • PROSITE:PS00226 (1)
  • Pfam:PF00038 (1)
  • Pfam:PF04732 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA gfap-001 (1) 2651
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-gfap (1), Ab2-gfap (1), Ab4-gfap (1), zrf-1 (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM gfap
    Et(gfap:EGFP), Tg(2.3gfap:GFP), Tg(gfap:Cre-ERT2,cryaa:YFP), Tg(gfap:EGFP), Tg(gfap:GAL4FF) (all 11) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    gfapContained in: [BAC] DKEY-15N1 (1) (order this)
    gfapContains: [SNP] rs3727711 (1)
    gfapEncodes: [EST] af506734, cb345 (1) (order this), fb34h11 (1), fk42c12 (1)
    [cDNA] MGC:110485 (1) (order this), MGC:191386 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131373 (1) 2570bp
    Genomic GenBank:BX324157 (1) 272769bp Blast at MegaBLAST
    Polypeptide UniProtKB:B2GP50 (1) 444aa
    Sequence Clusters UniGene:32667 (1)
    Sequence Information (all 48)
    OTHER gfap GENE PAGES
  • Gene:30646 (1)
  • VEGA:OTTDARG00000019974 (1)
  • Ensembl(GRCz10):ENSDARG00000025301 (1)
  • ORTHOLOGY for gfap (Chr: 3)
    Species Symbol Chromosome Accession # Evidence
    Human GFAP 17
  • Gene:2670
  • OMIM:137780
  • HGNC:4235
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (1)
    Mouse Gfap 11
  • MGI:95697
  • Gene:14580
  • Nucleotide sequence comparison (1)
    Download Curated Orthology
    CITATIONS (112)