ZFIN ID: ZDB-GENE-990914-3
Gene Name: glial fibrillary acidic protein
Gene Symbol: gfap
Previous Names: af506734 (1), cb345 (1), etID36982.3 (1), wu:fb34h11 (1), wu:fk42c12, xx:af506734 (1), zgc:110485, zrf-1 antigen (1)
Location: Chr: 3   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 67 figures from 42 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2001 [cb345]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
  alar plate midbrain region, anterior commissure axon, anterior commissure glial cell, anterior commissure glial cell (sensu Vertebrata) (all 50) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: CRISPR1-gfap (1), TALEN1-gfap (1)

Allele Type Mutagen Suppliers
sa20045 Point Mutation ENU
PHENOTYPE No data available
DISEASE ASSOCIATED WITH gfap HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
Alexander disease Alexander disease 203450
GENE ONTOLOGY
Ontology GO Term
Cellular Component cytoplasm (more)
Molecular Function structural molecule activity (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001664 (1)
  • InterPro:IPR002957 (1)
  • InterPro:IPR006821 (1)
  • InterPro:IPR018039 (1)
  • InterPro:IPR027701 (1)
  • PROSITE:PS00226 (1)
  • Pfam:PF00038 (1)
  • Pfam:PF04732 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA gfap-001 (1) 2651
    GENE PRODUCT DESCRIPTION
    ANTIBODIES
    Ab1-gfap (1), Ab2-gfap (1), Ab4-gfap (1), zrf-1 (1)
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM gfap
    Et(gfap:EGFP), Tg(2.3gfap:GFP), Tg(gfap:EGFP), Tg(gfap:GFP), Tg(gfap:LEXPR,LEXOP:EGFP) (all 9) expand
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    gfap Contained in: [BAC] DKEY-15N1 (1) (order this)
    gfap Contains: [SNP] rs3727711 (1)
    gfap Encodes: [EST] af506734, cb345 (1) (order this), fb34h11 (1), fk42c12 (1)
    [cDNA] MGC:110485 (1) (order this), MGC:191386 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131373 (1) 2570 bp
    Genomic GenBank:BX324157 (1) 272769 bp Blast at MegaBLAST
    Polypeptide UniProtKB:B2GP50 (1) 444 aa
    Sequence Clusters UniGene:32667 (1)
    Sequence Information (all 48)
    OTHER gfap GENE PAGES
  • Gene:30646 (1)
  • VEGA:OTTDARG00000019974 (1)
  • Ensembl(Zv9):ENSDARG00000025301 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA NT CL
    Zebrafish gfap 3  
    Human GFAP 17 (17q21)
  • OMIM:137780
  • Gene:2670
  • Mouse Gfap 11 ( 66.48 cM)
  • MGI:95697
  • Gene:14580
  • Orthology Details
    CITATIONS (102)