Gene

frzb

ID
ZDB-GENE-990715-1
Name
frizzled related protein
Symbol
frzb Nomenclature History
Previous Names
  • cb291 (1)
  • fzb1
  • id:ibd5075
  • ik:tdsubc_2e7 (1)
  • sfrp3 (1)
  • xx:tdsubc_2e7
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have Wnt-protein binding activity. Involved in chondrocyte proliferation. Predicted to localize to cytoplasm and extracellular space. Is expressed in several structures, including germ ring; head; hypochord; mesoderm; and nervous system. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and osteoarthritis. Orthologous to human FRZB (frizzled related protein).
Genome Resources
Note
None
Expression
All Expression Data
19 figures from 9 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
6 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With frzb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Osteoarthritis susceptibility 1} 165720
Associated With frzb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001134 Netrin domain
Domain IPR018933 Netrin module, non-TIMP type
Domain IPR020067 Frizzled domain
Domain IPR035813 Secreted frizzled-related protein 3, NTR domain
Domain IPR041759 SFRP3, cysteine-rich domain
Family IPR015526 Frizzled/secreted frizzled-related protein
Family IPR026556 Secreted frizzled-related protein 3
Homologous_superfamily IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Homologous_superfamily IPR036790 Frizzled cysteine-rich domain superfamily
Domain Details Per Protein
Protein Length Frizzled cysteine-rich domain superfamily Frizzled domain Frizzled/secreted frizzled-related protein Netrin domain Netrin module, non-TIMP type Secreted frizzled-related protein 3 Secreted frizzled-related protein 3, NTR domain SFRP3, cysteine-rich domain Tissue inhibitor of metalloproteinases-like, OB-fold
UniProtKB:Q9W6E0 315
UniProtKB:A0A0B5JQ70 315
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations