ZFIN ID: ZDB-GENE-990714-20
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Gene Name: teneurin transmembrane protein 4
Gene Symbol: tenm4    Nomenclature History

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Previous Names: tenm4, nrg1, odz4

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have cell adhesion molecule binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in axon guidance. Predicted to localize to several cellular components, including the neuron projection; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in essential tremor. Is expressed in several structures, including anterior neural plate; brain; midbrain hindbrain boundary neural rod; optic vesicle; and posterior neural tube. Orthologous to human TENM4 (teneurin transmembrane protein 4).
Genome Resources: Alliance (1),  Gene:30156 (1),  Ensembl(GRCz11):ENSDARG00000105088 (1)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la019130Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la027586Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa10710 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa12130 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa22594 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa24976 Point Mutation Unknown Premature Stop ENU
    sa35813 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa39035 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa42497 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa42498 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa44819 Point Mutation Unknown Unknown ENU
    sa44820 Point Mutation Unknown Unknown ENU
    sa44821 Point Mutation Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tenm4 N/A 1
    MO2-tenm4 N/A 1
    PHENOTYPE
    Data: Fig. 3 from Hor et al., 2015
    Observed in:
    DISEASE ASSOCIATED WITH tenm4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    essential tremor 5 Alliance Essential tremor, hereditary, 5 616736
    DISEASE ASSOCIATED WITH tenm4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon guidance (more)
    Cellular Component cytoplasm (more)
    Molecular Function protein heterodimerization activity (more)
    GO Terms (all 24)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000742 EGF-like domain
    Repeat IPR006530 YD repeat
    Homologous_superfamily IPR008969 Carboxypeptidase-like, regulatory domain superfamily
    Domain IPR009471 Teneurin intracellular, N-terminal
    Homologous_superfamily IPR011041 Soluble quinoprotein glucose/sorbosone dehydrogenase
    Homologous_superfamily IPR011042 Six-bladed beta-propeller, TolB-like
    Conserved_site IPR013032 EGF-like, conserved site
    Domain IPR022385 Rhs repeat-associated core
    Family IPR027691 Teneurin-4
    Domain IPR028916 Tox-GHH domain
    Repeat IPR031325 RHS repeat
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tenm4-201 (1)    Ensembl 534
    Select Tool
    tenm4-204 (1)    Ensembl 9523
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tenm4 No data available
    MARKER RELATIONSHIPS
    tenm4 Contained in: [BAC] CH73-388B5 (1), CH211-197B11 (1), DKEY-94I17 (1) (order this), DKEY-194O19 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130969 (1) 9264 bp
    Select Tool
    Genomic GenBank:AL807754 (1) 193544 bp
    Select Tool
    Polypeptide UniProtKB:A0A286Y9C5 (1) 2865 aa
    Select Tool
    Sequence Information (all 39)
    ORTHOLOGY for tenm4 ( Chr: 15 )
    CITATIONS (26)