Gene

tenm4

ID

ZDB-GENE-990714-20

Name

teneurin transmembrane protein 4

Symbol

tenm4 Nomenclature History

Previous Names

tenm4
nrg1
odz4

Type

protein_coding_gene

Location

Chr: 15 Mapping Details/Browsers

Description

Predicted to have cell adhesion molecule binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in axon guidance. Predicted to localize to several cellular components, including neuron projection; nucleus; and plasma membrane. Is expressed in several structures, including brain; midbrain hindbrain boundary neural rod; neural tube; optic vesicle; and retina. Human ortholog(s) of this gene implicated in essential tremor 5. Orthologous to human TENM4 (teneurin transmembrane protein 4).

Genome Resources

Note

None

Expression

All Expression Data

7 figures from 2 publications

Cross-Species Comparison

High Throughput Data

No data available

Thisse Expression Data

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Hor et al., 2015
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tenm4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
essential tremor 5	Alliance	Essential tremor, hereditary, 5	616736

Associated With tenm4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR009471	Teneurin intracellular, N-terminal
Domain	IPR022385	Rhs repeat-associated core
Domain	IPR028916	Tox-GHH domain
Family	IPR027691	Teneurin-3/4
Homologous_superfamily	IPR008969	Carboxypeptidase-like, regulatory domain superfamily
Homologous_superfamily	IPR011041	Soluble quinoprotein glucose/sorbosone dehydrogenase
Homologous_superfamily	IPR011042	Six-bladed beta-propeller, TolB-like
Repeat	IPR006530	YD repeat
Repeat	IPR031325	RHS repeat

Domain Details Per Protein

Protein	Length	Carboxypeptidase-like, regulatory domain superfamily	EGF-like domain	RHS repeat	Rhs repeat-associated core	Six-bladed beta-propeller, TolB-like	Soluble quinoprotein glucose/sorbosone dehydrogenase	Teneurin-3/4	Teneurin intracellular, N-terminal	Tox-GHH domain	YD repeat
UniProtKB:A0A286Y9C5 InterPro	2865
UniProtKB:A0A2R8QIZ5 InterPro	2840
UniProtKB:A0A0R4ICV6 InterPro	2831
UniProtKB:A0A2R8Q661 InterPro	2792
UniProtKB:A0A0R4IN22 InterPro	2824
UniProtKB:A0A0R4IGJ8 InterPro	2772
UniProtKB:Q9W7R3 InterPro	2824
UniProtKB:A0A0R4IZR2 InterPro	83
UniProtKB:A0A2R8RZ80 InterPro	2798

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	tenm4-201 (1) Ensembl	534 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tenm4-204 (1) Ensembl	9523 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Gene Tree: Ensembl

Citations