ZFIN ID: ZDB-GENE-990714-19
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Gene Name: teneurin transmembrane protein 3
Gene Symbol: tenm3    Nomenclature History

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Previous Names: cb399 (1), id:ibd3379, odd Oz/ten-m homolog 3 (1), odz3 (1), seizure resistant s334 (1), srs334 (1), tenascin-M3 (1), zgc:153720

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have cell adhesion molecule binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in dendrite guidance; retinal ganglion cell axon guidance; and visual perception. Predicted to localize to the integral component of plasma membrane and neuron projection. Is expressed in several structures, including immature eye; mesoderm; nervous system; neural tube; and pectoral fin. Orthologous to human TENM3 (teneurin transmembrane protein 3).
Genome Resources: Alliance (1),  Gene:30155 (1),  Ensembl(GRCz11):ENSDARG00000005479 (2)
GENE EXPRESSION
All Expression Data: 18 figures from 8 publications
Directly Submitted Expression Data: 1 figure (1 image) from Kudoh et al., 2001 [ibd3379]
  6 figures (23 images) from Thisse et al., 2001 [cb399]
Wild-type Stages, Structures: Gastrula:Bud (10.0h-10.33h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
kg69 Small Deletion Unknown Frameshift, Premature Stop TALEN
la013653Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la013654Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la013655Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la021165Tg Transgenic Insertion Unknown Unknown DNA
    la021166Tg Transgenic Insertion Unknown Unknown DNA
    la021168Tg Transgenic Insertion Unknown Unknown DNA
    la021169Tg Transgenic Insertion Unknown Unknown DNA
    la028143Tg Transgenic Insertion Unknown Unknown DNA
    la028144Tg Transgenic Insertion Unknown Unknown DNA
    la028145Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • s334 Complex Unknown Unknown
    sa1982 Point Mutation Unknown Premature Stop ENU
    sa5941 Point Mutation Unknown Premature Stop ENU
    sa7384 Point Mutation Unknown Missense ENU
    sa19536 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa24853 Point Mutation Unknown Splice Site ENU
    sa32721 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • zko730a Insertion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
    • zko730b Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-tenm3 1
    MO1-tenm3 N/A 1
    MO2-tenm3 N/A 1
    TALEN1-tenm3 1
    PHENOTYPE
    Data: 5 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH tenm3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Microphthalmia, syndromic 15 615145
    ?Microphthalmia, isolated, with coloboma 9 615145
    DISEASE ASSOCIATED WITH tenm3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dendrite guidance (more)
    Cellular Component integral component of plasma membrane (more)
    Molecular Function protein heterodimerization activity (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000742 EGF-like domain
    Repeat IPR006530 YD repeat
    Homologous_superfamily IPR008969 Carboxypeptidase-like, regulatory domain superfamily
    Domain IPR009471 Teneurin intracellular, N-terminal
    Homologous_superfamily IPR011042 Six-bladed beta-propeller, TolB-like
    Conserved_site IPR013032 EGF-like, conserved site
    Domain IPR022385 Rhs repeat-associated core
    Family IPR027689 Teneurin-2/3
    Domain IPR028916 Tox-GHH domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tenm3-201 (1)    Ensembl 1469
    Select Tool
    tenm3-204 (1)    Ensembl 11289
    Select Tool
    tenm3-206 (1)    Ensembl 8719
    Select Tool
    ncRNA tenm3-002 (1) 627
    Select Tool
    tenm3-003 (1) 653
    Select Tool
    Browsers: UCSC,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-tenm3 Rabbit IHC 1
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tenm3
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(tenm3:GAL4FF) tenm3 GAL4FF Danio rerio 1 1
    MARKER RELATIONSHIPS
    tenm3 Contained in: [BAC] CH211-42A2 (1), CH211-79C1 (1), CH211-214H9 (1), RP71-38B8 (1)
    tenm3 Encodes: [EST] cb399 (1) (order this), ibd3379, fc68f07 (1)
    [cDNA] MGC:153720 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130968 (1) 8816 bp
    Select Tool
    Genomic GenBank:BX005481 (1) 170604 bp
    Select Tool
    Polypeptide UniProtKB:F8W4C5 (1) 2694 aa
    Select Tool
    Sequence Information (all 31)
    ORTHOLOGY for tenm3 ( Chr: 1 )
    CITATIONS (44)