Gene

tenm3

ID

ZDB-GENE-990714-19

Name

teneurin transmembrane protein 3

Symbol

tenm3 Nomenclature History

Previous Names

cb399 (1)
id:ibd3379
odd Oz/ten-m homolog 3 (1)
odz3 (1)
seizure resistant s334 (1)
srs334 (1)
tenascin-M3 (1)
zgc:153720

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Is predicted to enable cell adhesion molecule binding activity; protein heterodimerization activity; and protein homodimerization activity. Involved in several processes, including heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and regulation of homophilic cell adhesion. Acts upstream of or within dendrite guidance; retinal ganglion cell axon guidance; and visual perception. Predicted to be integral component of plasma membrane. Is expressed in several structures, including fin bud; immature eye; mesoderm; nervous system; and neural tube. Orthologous to human TENM3 (teneurin transmembrane protein 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 8 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

cb399 (23 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tenm3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Microphthalmia, syndromic 15	615145
		?Microphthalmia, isolated, with coloboma 9	615145

Associated With tenm3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000742	EGF-like domain
Domain	IPR009471	Teneurin intracellular, N-terminal
Domain	IPR022385	Rhs repeat-associated core
Domain	IPR028916	Tox-GHH domain
Family	IPR027691	Teneurin-3/4
Homologous_superfamily	IPR008969	Carboxypeptidase-like, regulatory domain superfamily
Homologous_superfamily	IPR011042	Six-bladed beta-propeller, TolB-like
Repeat	IPR006530	YD repeat

Domain Details Per Protein

Protein	Length	Carboxypeptidase-like, regulatory domain superfamily	EGF-like domain	Rhs repeat-associated core	Six-bladed beta-propeller, TolB-like	Teneurin-3/4	Teneurin intracellular, N-terminal	Tox-GHH domain	YD repeat
UniProtKB:D0EY69 InterPro	2590
UniProtKB:Q9W7R4 InterPro	2694
UniProtKB:Q0D280 InterPro	189
UniProtKB:F8W4C5 InterPro	2694

Transcripts

Genome Browsers

UCSC

Ensembl

ZFIN

Type	Name	Length (nt)	Analysis
mRNA	tenm3-201 (1) Ensembl	1469 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tenm3-204 (1) Ensembl	11289 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tenm3-206 (1) Ensembl	8719 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	tenm3-002 (1) Ensembl	627 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	tenm3-003 (1) Ensembl	653 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

Name	Type	Antigen Genes	Isotype	Host Organism	Assay	Source	Citations
Ab1-tenm3		tenm3		Rabbit	IHC		1

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations