Gene

lft1

ID
ZDB-GENE-990630-10
Name
lefty1
Symbol
lft1 Nomenclature History
Previous Names
  • antivin
  • atv
  • cb73 (1)
  • ik:tdsubc_2b12
  • xx:tdsubc_2b12
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have cytokine activity. Involved in determination of left/right symmetry; dorsal/ventral pattern formation; and embryonic heart tube development. Predicted to localize to extracellular space. Is expressed in several structures, including blastodisc; brain; germ ring; mesoderm; and tail bud. Orthologous to several human genes including LEFTY2 (left-right determination factor 2).
Genome Resources
Note
None
Expression
All Expression Data
132 figures from 94 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With lft1 Human Ortholog
No data available
Associated With lft1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017948 Transforming growth factor beta, conserved site
Domain IPR001111 TGF-beta, propeptide
Domain IPR001839 Transforming growth factor-beta, C-terminal
Family IPR003942 Left- Right determination factor
Family IPR015615 Transforming growth factor-beta-related
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine Left- Right determination factor TGF-beta, propeptide Transforming growth factor beta, conserved site Transforming growth factor-beta, C-terminal Transforming growth factor-beta-related
UniProtKB:Q9W6I6 358
UniProtKB:Q9PW55 358
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
AB1-lft1 polyclonal
2
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations