ZFIN ID: ZDB-GENE-990630-10
Gene Name: lefty1
Gene Symbol: lft1    Nomenclature History

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Previous Names: antivin, atv, cb73 (1), ik:tdsubc_2b12, xx:tdsubc_2b12

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have cytokine activity and transforming growth factor beta receptor binding activity. Involved in determination of left/right symmetry; dorsal/ventral pattern formation; and embryonic heart tube development. Predicted to localize to the extracellular space. Is expressed in several structures, including blastodisc; brain; germ ring; mesoderm; and tail bud. Orthologous to several human genes including LEFTY2 (left-right determination factor 2).
Genome Resources: Alliance (1),  Gene:30145 (1),  Ensembl(GRCz11):ENSDARG00000019920 (1)
GENE EXPRESSION
All Expression Data: 132 figures from 94 publications
Directly Submitted Expression Data: 7 figures (25 images) from Thisse et al., 2001 [cb73]
Wild-type Stages, Structures: Blastula:Sphere (4.0h-4.33h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a145 Indel Unknown Unknown TALEN
hg6 Point Mutation Unknown Unknown ENU
hg7 Point Mutation Unknown Unknown ENU
sa15195 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23761 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-lft1 N/A 7
    MO2-lft1 N/A 2
    MO3-lft1 N/A 3
    MO4-lft1 N/A 2
    MO5-lft1 N/A 1
    MO6-lft1 N/A 1
    TALEN1-lft1 1
    DISEASE ASSOCIATED WITH lft1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH lft1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal/ventral pattern formation (more)
    Cellular Component extracellular region (more)
    Molecular Function cytokine activity (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR017948 Transforming growth factor beta, conserved site
    Domain IPR001111 TGF-beta, propeptide
    Domain IPR001839 Transforming growth factor-beta, C-terminal
    Family IPR003942 Left- Right determination factor
    Family IPR015615 Transforming growth factor-beta-related
    Homologous_superfamily IPR029034 Cystine-knot cytokine
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lft1-201 (1)    Ensembl 1381
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    AB1-lft1 polyclonal 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lft1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-13.5lft1:EGFP) lft1 EGFP Danio rerio 1 6
    Tg(UAS:lft1-UTRnanos3) UAS lft1nanos3UTR Danio rerio 1 1
    MARKER RELATIONSHIPS
    lft1 Contained in: [BAC] DKEYP-8F4 (1)
    lft1 Encodes: [EST] cb73 (3) (order this), tdsubc_2b12 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_130960 (1) 1381 nt
    Genomic GenBank:BX470246 (1) 148286 nt
    Select Tool
    Polypeptide UniProtKB:Q9PW55 (1) 358 aa
    Sequence Information (all 11)
    ORTHOLOGY for lft1 ( Chr: 20 )
    CITATIONS (205)