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ZIRC
ZFIN ID: ZDB-GENE-990415-93
Gene Name: serpin peptidase inhibitor, clade H (heat shock protein 47), member 1b
Gene Symbol: serpinh1b    Nomenclature History

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Previous Names: hsp47, cb216 (1), fc56b02, id:ibd5060 (1), wu:fc56b02 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have serine-type endopeptidase inhibitor activity. Involved in fin regeneration. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 10 and preterm premature rupture of the membranes. Is expressed in several structures, including ectoderm; fin; germ ring; mesenchyme derived from head mesoderm; and mesoderm. Orthologous to human SERPINH1 (serpin family H member 1).
Genome Resources: Alliance (1),  Gene:30449 (1),  Ensembl(GRCz11):ENSDARG00000019949 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la019300Tg Transgenic Insertion Unknown Unknown DNA
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-serpinh1b
2
CRISPR3-serpinh1b
2
CRISPR4-serpinh1b
2
MO1-serpinh1b N/A 1
DISEASE ASSOCIATED WITH serpinh1b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
osteogenesis imperfecta type 10 Alliance Osteogenesis imperfecta, type X 613848
preterm premature rupture of the membranes Alliance {Preterm premature rupture of the membranes, susceptibility to} 610504
DISEASE ASSOCIATED WITH serpinh1b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process fin regeneration (more)
Cellular Component extracellular space (more)
Molecular Function collagen binding (more)
GO Terms (all 5)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA serpinh1b-201 (1)    Ensembl 2084
serpinh1b-204 (1)    Ensembl 848
ncRNA serpinh1b-003 (1)    Ensembl 804
serpinh1b-004 (1)    Ensembl 1130
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM serpinh1b No data available
MARKER RELATIONSHIPS
serpinh1b Contained in: [BAC] DKEY-52L18 (1) (order this)
serpinh1b Encodes: [EST] cb216 (1) (order this), fc56b02, ibd5060 (order this)
[cDNA] MGC:86594 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131204 (1) 2006 bp
Genomic GenBank:BX537138 (1) 144274 bp
Select Tool
Polypeptide UniProtKB:F1QQ04 (1) 405 aa
Sequence Clusters UniGene:32911 (1)
Sequence Information (all 21)
ORTHOLOGY for serpinh1b ( Chr: 15 )
CITATIONS (50)