ZFIN ID: ZDB-GENE-990415-9
Gene Name: activin A receptor, type 1 like
Gene Symbol: acvr1l    Nomenclature History

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Previous Names: acvr1, alk2 (1), alk8, alk8sum, etID124543.2 (1), fk50h05, laf, lost a fin, lost-a-fin (2), mfn (1), mini fin (1), wu:fk50h05 (1), zalk8

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have ATP binding activity and transforming growth factor beta receptor activity, type I. Involved in several processes, including animal organ development; embryonic morphogenesis; and regionalization. Localizes to BMP receptor complex and cell cortex. Is expressed in brain; ceratobranchial 5 tooth; immature eye; liver; and tooth placode. Human ortholog(s) of this gene implicated in fibrodysplasia ossificans progressiva. Orthologous to human ACVR1 (activin A receptor type 1).
Genome Resources: Alliance (1),  Gene:30615 (1),  Ensembl(GRCz11):ENSDARG00000014986 (2)
GENE EXPRESSION
All Expression Data: 12 figures from 9 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7151393]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
acvr1l_unspecified Unspecified Unknown Unknown
gl2 Point Mutation Unknown Premature Stop ENU
m100 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2068 Point Mutation Unknown Splice Site ENU
    sa18736 Point Mutation Unknown Splice Site ENU
    sa38350 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39902 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sk42 Unknown Unknown Unknown ENU
    tm110b Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-acvr1l
    2
    CRISPR2-acvr1l
    2
    MO1-acvr1l N/A 3
    MO2-acvr1l N/A 7
    MO3-acvr1l N/A 3
    MO4-acvr1l N/A 1
    MO5-acvr1l N/A 1
    DISEASE ASSOCIATED WITH acvr1l HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH acvr1l VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of ventral identity (more)
    Cellular Component BMP receptor complex (more)
    Molecular Function protein binding (more)
    GO Terms (all 52)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA acvr1l-201 (1)    Ensembl 3499
    acvr1l-202 (1)    Ensembl 457
    ncRNA acvr1l-002 (1)    Ensembl 396
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    AB1-acvr1l polyclonal Rabbit 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM acvr1l
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:acvr1l) hsp70l acvr1l Danio rerio 1 4
    Tg(hsp70l:acvr1l-mCherry) hsp70l acvr1lmCherry Danio rerio 1 1
    Tg(hsp70l:acvr1l_Q204D-mCherry) hsp70l acvr1lmCherry Danio rerio 1 2
    MARKER RELATIONSHIPS
    acvr1l Contained in: [BAC] CH211-62C1 (1)
    acvr1l Encodes: [EST] fk50h05 (1), IMAGE:7151393 (1)
    [cDNA] MGC:193928 (1), MGC:193932 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131345 (1) 3474 nt
    Genomic GenBank:CT476817 (1) 173555 nt
    Select Tool
    Polypeptide UniProtKB:O73736 (1) 506 aa
    Sequence Information (all 24)
    ORTHOLOGY for acvr1l ( Chr: 2 )
    CITATIONS (112)