ZFIN ID: ZDB-GENE-021003-1
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Gene Name: activin A receptor like type 1
Gene Symbol: acvrl1
Sequence Ontology ID : SO:0000704

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Previous Names: vbg, alk1 (1), hm:zehn1109 (1), violet beauregarde, zehn1109

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(Including Attributions)
Location: Chr: 23 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to contribute to activin receptor activity, type I; involved in several processes, including artery morphogenesis, blood vessel endothelial cell migration, and determination of ventral  ...
GENE EXPRESSION
All Expression Data: 7 figures from 5 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu653]
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Pharyngula:Prim-25 (36.0h-42.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ft09e Point Mutation Unknown Premature Stop ENU
s407 Point Mutation Intron 8 Unknown ENU
y6 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Targeting reagents:
    PHENOTYPE
    Data: 23 figures from 9 publications
    Observed in:
    DISEASE ASSOCIATED WITH acvrl1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    hereditary hemorrhagic telangiectasia Telangiectasia, hereditary hemorrhagic, type 2 600376
    DISEASE ASSOCIATED WITH acvrl1 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    arteriovenous malformation WT + MO3-acvrl1 standard conditions Walcott, 2014
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of ventral identity (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000333 (1)
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR003605 (1)
  • InterPro:IPR008271 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR017441 (1)
    		•
  • PROSITE:PS00107 (1)
  • PROSITE:PS00108 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS51256 (1)
    		•
  • Pfam:PF07714 (1)
  • Pfam:PF08515 (1)
    		•
  • EC:2.7.11.30 (1)
    		•
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA acvrl1-001 (1) 2794
    Select Tool
    acvrl1-002 (1) 2321
    Select Tool
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM acvrl1
    MARKER RELATIONSHIPS
    acvrl1Contained in: [BAC] CH211-169D8 (1) (order this)
    acvrl1Encodes: [EST] eu653 (1), zehn1109 (1)
    [cDNA] MGC:111915 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_153643 (1) 2674bp
    Select Tool
    Genomic GenBank:CR387931 (1) 144701bp
    Select Tool
    Polypeptide UniProtKB:F1QH44 (1) 502aa
    Select Tool
    Sequence Clusters UniGene:78142 (1)
    Sequence Information (all 27)
    OTHER acvrl1 GENE PAGES
  • Alliance (1)
  • Gene:266753 (1)
  • VEGA:OTTDARG00000028142 (1)
  • Ensembl(GRCz11):ENSDARG00000018179 (2)
    • ORTHOLOGY for acvrl1 (Chr: 23)
    CITATIONS (50)