ZFIN Gene: acvrl1

ZFIN ID: ZDB-GENE-021003-1

ZFIN ID: ZDB-GENE-021003-1

Gene Name:

activin A receptor like type 1

Gene Symbol:

acvrl1

Sequence Ontology ID :

SO:0000704

Previous Names:

vbg, alk1 (1), hm:zehn1109 (1), violet beauregarde, zehn1109

Location:

Chr: 23 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to contribute to activin receptor activity, type I. Involved in several processes, including artery morphogenesis; blood vessel endothelial cell migration; and determination of ventral ...

GENE EXPRESSION
All Expression Data:	7 figures from 5 publications
Directly Submitted Expression Data:	1 figure (1 image) from Thisse et al., 2005 [eu653]
Wild-type Stages, Structures:	Pharyngula:Prim-5 (24.0h-30.0h) to Pharyngula:Prim-25 (36.0h-42.0h)
	aortic arch 1 basal communicating artery caudal division of the internal carotid artery cranial division of the internal carotid artery cranial vasculature artery cranial vasculature dorsal aorta internal carotid artery lateral dorsal aorta optic artery optic vein posterior cardinal vein
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
ft09e	Point Mutation	Unknown	Premature Stop	ENU
s407	Point Mutation	Intron 8	Unknown	ENU
y6	Point Mutation	Unknown	Missense	ENU	Zebrafish International Resource Center (ZIRC) (order this)

Targeting reagents:

PHENOTYPE

Data:

23 figures from 9 publications

Observed in:

DISEASE ASSOCIATED WITH acvrl1 HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
hereditary hemorrhagic telangiectasia	Telangiectasia, hereditary hemorrhagic, type 2	600376

DISEASE ASSOCIATED WITH acvrl1 VIA EXPERIMENTAL MODELS

Human Disease	Fish	Conditions	Citations
arteriovenous malformation	WT + MO3-acvrl1	standard conditions	Walcott, 2014

GENE ONTOLOGY

Ontology	GO Term
Biological Process	determination of ventral identity (more)
Cellular Component	integral component of membrane (more)
Molecular Function	ATP binding (more)

GO Terms (all 30)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000333 (1) InterPro:IPR000719 (1) InterPro:IPR001245 (1) InterPro:IPR003605 (1) InterPro:IPR008271 (1) InterPro:IPR011009 (1) InterPro:IPR017441 (1)	PROSITE:PS00107 (1) PROSITE:PS00108 (1) PROSITE:PS50011 (1) PROSITE:PS51256 (1)	Pfam:PF07714 (1) Pfam:PF08515 (1)	EC:2.7.11.30 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	acvrl1-201 (1)	2794	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
	acvrl1-202 (1)	2321	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

SignaFish

ANTIBODIES

AB1-acvr1l (1)

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM acvrl1

Tg(fli1a:acvrl1-MYC)

MARKER RELATIONSHIPS

acvrl1Contained in:	[BAC] CH211-169D8 (1) (order this)
acvrl1Encodes:	[EST] eu653 (1), zehn1109 (1) [cDNA] MGC:111915 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_153643 (1)	2674bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR387931 (1)	144701bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:F1QH44 (1)	502aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:78142 (1)

Sequence Information (all 27)

OTHER acvrl1 GENE PAGES

Alliance (1)

Gene:266753 (1)

VEGA:OTTDARG00000028142 (1)

Ensembl(GRCz11):ENSDARG00000018179 (2)

ORTHOLOGY for acvrl1 (Chr: 23)

CITATIONS (53)

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