ZFIN ID: ZDB-GENE-980526-29
Gene Name: deltaA
Gene Symbol: dla    Nomenclature History

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Previous Names: cb335 (1), delta A, fa04c10, wu:fa04c10 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have Notch binding activity. Involved in several processes, including animal organ development; floor plate development; and regulation of Notch signaling pathway. Localizes to the cell cortex and plasma membrane. Is expressed in several structures, including ectoderm; nervous system; neural keel; neural plate; and neural tube. Orthologous to human DLL1 (delta like canonical Notch ligand 1).
Genome Resources: Alliance (1),  Gene:30131 (1),  Ensembl(GRCz11):ENSDARG00000010791 (2)
GENE EXPRESSION
All Expression Data: 113 figures from 68 publications
Directly Submitted Expression Data: 6 figures (24 images) from Thisse et al., 2001 [cb335]
Wild-type Stages, Structures: Gastrula:90%-epiboly (9.0h-10.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
dx2 Point Mutation Unknown Missense ENU
hi781Tg Transgenic Insertion Exon 2 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi840Tg Transgenic Insertion Exon 2 Unknown DNA
    hi3499Tg Transgenic Insertion 5' UTR Unknown DNA
    nkhspGFFDMC72AEt Transgenic Insertion Unknown Unknown DNA
    sa19611 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko1078a Indel Unknown Unknown CRISPR
    zko1078b Insertion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-dla 1
    MO1-dla N/A 10
    MO2-dla N/A 2
    MO3-dla N/A 2
    MO4-dla N/A 1
    DISEASE ASSOCIATED WITH dla HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures 618709
    DISEASE ASSOCIATED WITH dla VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process diencephalon development (more)
    Cellular Component cell cortex (more)
    Molecular Function protein binding (more)
    GO Terms (all 25)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
    Domain IPR000742 EGF-like domain
    Domain IPR001774 Delta/Serrate/lag-2 (DSL) protein
    Domain IPR001881 EGF-like calcium-binding domain
    Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
    Domain IPR011651 Notch ligand, N-terminal domain
    Conserved_site IPR013032 EGF-like, conserved site
    Conserved_site IPR018097 EGF-like calcium-binding, conserved site
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dla-201 (1)    Ensembl 3986
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-dla monoclonal IgG1 Mouse IHC Zebrafish International Resource Center (ZIRC)  (order this)
    6
    Ab2-dla monoclonal IgG2a Mouse IHC 1
    Ab1-dld monoclonal IgG1 Mouse IHC, WB Abcam plc
    18
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dla
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-2.9dla:GFP) dla GFP Danio rerio 1 2
    Tg(dla:GFP) dla GFP Danio rerio 1 6
    MARKER RELATIONSHIPS
    dla Contained in: [BAC] CH211-133L11 (1)
    dla Encodes: [EST] cb335 (1) (order this), fa04c10 (1)
    [cDNA] cssl:d399 (1), MGC:86576 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130954 (1) 3051 bp
    Genomic GenBank:AL929114 (1) 180158 bp
    Select Tool
    Polypeptide UniProtKB:F1QWN4 (1) 795 aa
    Sequence Information (all 24)
    ORTHOLOGY for dla ( Chr: 1 )
    CITATIONS (170)