Gene

dla

ID
ZDB-GENE-980526-29
Name
deltaA
Symbol
dla Nomenclature History
Previous Names
  • cb335 (1)
  • delta A
  • fa04c10
  • wu:fa04c10 (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have Notch binding activity. Involved in several processes, including animal organ development; floor plate development; and regulation of Notch signaling pathway. Localizes to cell cortex and plasma membrane. Is expressed in several structures, including ectoderm; nervous system; neural keel; neural plate; and neural tube. Orthologous to human DLL1 (delta like canonical Notch ligand 1).
Genome Resources
Note
None
Expression
All Expression Data
115 figures from 69 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
19 figures from 9 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dla Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neurodevelopmental disorder with nonspecific brain abnormalities and with or without seizures 618709
Associated With dla Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR013032 EGF-like, conserved site
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR001774 Delta/Serrate/lag-2 (DSL) protein
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR011651 Notch ligand, N-terminal domain
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Domain Details Per Protein
Protein Length Delta/Serrate/lag-2 (DSL) protein EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like, conserved site EGF-like domain EGF-type aspartate/asparagine hydroxylation site Growth factor receptor cysteine-rich domain superfamily Notch ligand, N-terminal domain
UniProtKB:F1R7K3 772
UniProtKB:Q6DI48 772
UniProtKB:F1QWN4 795
UniProtKB:A1C3M9 772
UniProtKB:A4JYR8 764
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-dla monoclonal IgG1 Mouse
  • IHC
Zebrafish International Resource Center (ZIRC)  (order this)
6
Ab2-dla monoclonal IgG2a Mouse
  • IHC
1
Ab1-dld monoclonal IgG1 Mouse
  • IHC
  • WB
Abcam plc
19
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations