ZFIN ID: ZDB-GENE-980526-171
Gene Name: T-box transcription factor 16, like
Gene Symbol: tbx16l    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: tbx6, tbx6l, z.TBX6 (1), ZF-TBX6 (1), cb123 (1), etID309793.5 (1), sb:cb123

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in paraxial mesoderm formation and somite development. Predicted to localize to nucleus. Is expressed in embryonic structure; hematopoietic system; mesoderm; and post-vent region. Human ortholog(s) of this gene implicated in spondylocostal dysostosis. Orthologous to human TBX6 (T-box transcription factor 6).
Genome Resources: Alliance (1),  Gene:30254 (1),  Ensembl(GRCz11):ENSDARG00000006939 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa31470 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • z34 Small Deletion Unknown Frameshift, Premature Stop TALEN
    z35 Small Deletion Unknown Frameshift, Premature Stop TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tbx16l N/A 1
    TALEN1-tbx16l
    1
    TALEN2-tbx16l 1
    PHENOTYPE
    Data: Fig. 4 from Morrow et al., 2017
    Observed in:
    DISEASE ASSOCIATED WITH tbx16l HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    spondylocostal dysostosis Alliance Spondylocostal dysostosis 5 122600
    DISEASE ASSOCIATED WITH tbx16l VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process paraxial mesoderm formation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tbx16l-201 (1)    Ensembl 3080
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tbx16l
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-1.7tbx16l:GFP) tbx16l GFP Danio rerio 1 5
    Tg(tbx16l:Cre,myl7:EGFP) myl7tbx16l CreEGFP Danio rerio 1 4
    Tg(tbx16l:Cre-ERT2,myl7:EGFP) myl7tbx16l CreEGFPERT2 Danio rerio 1 3
    Tg(tbx16l:fn1a-emGFP) tbx16l emGFPfn1a Danio rerio 1 1
    Tg(tbx16l:GAL4-VP16) tbx16l GAL4VP16 Danio rerio 1 4
    Tg(tbx16l:itga5-RFP) tbx16l itga5RFP Danio rerio 1 3
    MARKER RELATIONSHIPS
    tbx16l Contained in: [BAC] CH211-207C6 (1)
    tbx16l Encodes: [EST] cb123 (order this)
    [cDNA] MGC:109816 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131052 (1) 2871 nt
    Genomic GenBank:BX548073 (1) 222583 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B0S6U6 (1) 488 aa
    Sequence Information (all 20)
    ORTHOLOGY for tbx16l ( Chr: 5 )
    CITATIONS (138)