ZFIN ID: ZDB-GENE-980526-144
Gene Name: hairy-related 6
Gene Symbol: her6    Nomenclature History

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Previous Names: cb129 (1), Hes1b (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in Notch signaling pathway; nervous system development; and somite specification. Predicted to localize to the nucleus. Is expressed in several structures, including anterior neural keel; mesoderm; nervous system; neuronal stem cell; and pectoral fin. Orthologous to human HES1 (hes family bHLH transcription factor 1).
Genome Resources: Alliance (1),  Gene:30288 (1),  Ensembl(GRCz11):ENSDARG00000006514 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
el633 Small Deletion Unknown Frameshift TALEN
sa59 Point Mutation Unknown Unknown ENU
sa20748 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38559 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-her6 N/A 3
    MO2-her6 N/A 1
    MO3-her6 N/A 2
    TALEN1-her6 1
    DISEASE ASSOCIATED WITH her6 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH her6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior pattern specification (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR003650 Orange domain
    Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA her6-201 (1)    Ensembl 1426
    ncRNA her6-002 (1)    Ensembl 788
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM her6
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(her6-HNF1-Mmu.Fos:GFP) her6 GFP Danio rerioMus musculus 2 3
    Tg(her6-Mmu.Fos:GFP) her6 GFP Danio rerioMus musculus 4 2
    Tg(her6-RBPJ-Mmu.Fos:GFP) her6 GFP Danio rerioMus musculus 2 3
    MARKER RELATIONSHIPS
    her6 Contained in: [BAC] DKEY-111K7 (1) (order this)
    her6 Encodes: [EST] cb129 (1) (order this)
    [cDNA] MGC:73203 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131079 (1) 1372 bp
    Genomic GenBank:BX950188 (1) 260558 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q90468 (1) 334 aa
    Sequence Information (all 17)
    ORTHOLOGY for her6 ( Chr: 6 )
    CITATIONS (111)