Gene

mcf2la

ID
ZDB-GENE-090312-122
Name
mcf.2 cell line derived transforming sequence-like a
Symbol
mcf2la Nomenclature History
Previous Names
  • mcf2l
  • si:dkey-269p14.1
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of Rho protein signal transduction. Predicted to act upstream of or within intracellular signal transduction. Predicted to be active in cytoplasm. Predicted to be extrinsic component of membrane. Is expressed in several structures, including Kupffer's vesicle; chondrocyte; immature eye; mandibular arch skeleton; and yolk syncytial layer. Orthologous to human MCF2L (MCF.2 cell line derived transforming sequence like).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Mitchell et al., 2013
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mcf2la Human Ortholog
No data available
Associated With mcf2la Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR001331 Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain IPR000219 Dbl homology (DH) domain
Domain IPR001251 CRAL-TRIO lipid binding domain
Domain IPR001452 SH3 domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR035532 DBS, SH3 domain
Domain IPR035534 DBS, PH domain
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR035899 Dbl homology (DH) domain superfamily
Homologous_superfamily IPR036028 SH3-like domain superfamily
Homologous_superfamily IPR036865 CRAL-TRIO lipid binding domain superfamily
Domain Details Per Protein
Protein Length CRAL-TRIO lipid binding domain CRAL-TRIO lipid binding domain superfamily Dbl homology (DH) domain Dbl homology (DH) domain superfamily DBS, PH domain DBS, SH3 domain Guanine-nucleotide dissociation stimulator, CDC24, conserved site PH-like domain superfamily Pleckstrin homology domain SH3 domain SH3-like domain superfamily
UniProtKB:F1QQR4 213
UniProtKB:F1Q841 1166
UniProtKB:A0A0R4ISB6 1157
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations