ZFIN ID: ZDB-GENE-060503-86
Gene Name: keratin 17
Gene Symbol: krt17    Nomenclature History

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Previous Name: si:dkeyp-113d7.7

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 19 Mapping Details/Browsers
Description: Predicted to have structural molecule activity. Involved in fin regeneration. Predicted to localize to the intermediate filament. Human ortholog(s) of this gene implicated in ectodermal dysplasia; hereditary mucosal leukokeratosis; and pachyonychia congenita. Is expressed in EVL. Orthologous to several human genes including KRT13 (keratin 13) and KRT17 (keratin 17).
Genome Resources: Alliance (1),  Gene:100034647 (1),  Ensembl(GRCz11):ENSDARG00000094041 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 3 publications
Wild-type Stages, Structures: Blastula:30%-epiboly (4.66h-5.25h) to Gastrula:Shield (6.0h-8.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa23427 Point Mutation Unknown Missense, Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29144 Point Mutation Unknown Premature Stop ENU
    sa43209 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43210 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-krt17
    2
    CRISPR2-krt17
    2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH krt17 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH krt17 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fin regeneration (more)
    Cellular Component intermediate filament (more)
    Molecular Function structural molecule activity (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR039008 Intermediate filament, rod domain
    Family IPR002957 Keratin, type I
    Homologous_superfamily IPR042180 Intermediate filament, rod domain, coil 1B
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA krt17-201 (1)    Ensembl 1500
    krt17-202 (1)    Ensembl 869
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-krt17 monoclonal IgG2b Mouse WB Thermo Scientific Pierce Protein Research Products
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM krt17 No data available
    MARKER RELATIONSHIPS
    krt17 Contained in: [BAC] DKEYP-113D7 (1)
    krt17 Encodes: [cDNA] MGC:174182 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001083105 (1) 1384 nt
    Genomic GenBank:BX323079 (1) 165200 nt
    Select Tool
    Polypeptide UniProtKB:Q1LXJ1 (1) 423 aa
    Sequence Information (all 12)
    ORTHOLOGY for krt17 ( Chr: 19 )
    CITATIONS (26)