ZFIN ID: ZDB-GENE-051010-1
Gene Name: Indian hedgehog signaling molecule a
Gene Symbol: ihha    Nomenclature History

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Previous Names: hh[a] (1), hha, qhh (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have calcium ion binding activity and patched binding activity. Involved in several processes, including intramembranous ossification; osteoblast differentiation; and swim bladder morphogenesis. Predicted to localize to extracellular space. Is expressed in several structures, including caudal fin skeleton; cranium; digestive system; pneumatic duct; and swim bladder bud. Human ortholog(s) of this gene implicated in acrocapitofemoral dysplasia; brachydactyly type A1; retinopathy of prematurity; and syndactyly type 1. Orthologous to human IHH (Indian hedgehog signaling molecule).
Genome Resources: Alliance (1),  Gene:619520 (1),  Ensembl(GRCz11):ENSDARG00000058733 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu2131 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa30645 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34554 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ihha N/A 4
    DISEASE ASSOCIATED WITH ihha HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acrocapitofemoral dysplasia Alliance Acrocapitofemoral dysplasia 607778
    brachydactyly type A1 Alliance Brachydactyly, type A1 112500
    DISEASE ASSOCIATED WITH ihha VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process intramembranous ossification (more)
    Cellular Component membrane (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    antisense ottdart00000059270 (1) 1666
    mRNA ihha-201 (1)    Ensembl 1600
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ihha
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(UAS:EGFP,UAS:ihha) UAS EGFPihha Danio rerio 1 2
    MARKER RELATIONSHIPS
    ihha Contained in: [BAC] CH211-67P4 (1)
    ihha Encodes: [cDNA] MGC:162443 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001034993 (1) 1616 nt
    Genomic GenBank:BX942813 (1) 96772 nt
    Select Tool
    Polypeptide UniProtKB:A3KNS3 (1) 413 aa
    Sequence Information (all 13)
    ORTHOLOGY for ihha ( Chr: 9 )
    CITATIONS (62)