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ZIRC
ZFIN ID: ZDB-GENE-050506-61
Gene Name: vinculin a
Gene Symbol: vcla    Nomenclature History

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Previous Names: vcl, hm:zehn2160, im:6902790

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have actin filament binding activity and structural molecule activity. Involved in heart contraction; membrane repolarization during cardiac muscle cell action potential; and sarcomere organization. Localizes to the focal adhesion. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; dilated cardiomyopathy 1W; hypertrophic cardiomyopathy; and hypertrophic cardiomyopathy 15. Is expressed in several structures, including heart; lens; pectoral fin; solid lens vesicle; and somite. Orthologous to human VCL (vinculin).
Genome Resources: Alliance (1),  Gene:552980 (1),  Ensembl(GRCz11):ENSDARG00000044968 (2)
GENE EXPRESSION
All Expression Data: 11 figures from 7 publications
Directly Submitted Expression Data: 4 figures (7 images) from Thisse et al., 2004 [IMAGE:6902790]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns241 Small Deletion Exon 8 Premature Stop CRISPR
bns300 Insertion Exon 22 Unknown CRISPR
hu10818 Small Deletion Exon 4 Frameshift, Premature Stop TALEN
la018484Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10865 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14599 Point Mutation Exon 12 Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35485 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-vcla 1
    CRISPR2-vcla
    1
    MO1-vcla N/A 3
    MO2-vcla N/A 1
    TALEN1-vcla 1
    DISEASE ASSOCIATED WITH vcla HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    dilated cardiomyopathy 1W Alliance Cardiomyopathy, dilated, 1W 611407
    hypertrophic cardiomyopathy 15 Alliance Cardiomyopathy, hypertrophic, 15 613255
    DISEASE ASSOCIATED WITH vcla VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process heart contraction (more)
    Cellular Component adherens junction (more)
    Molecular Function actin binding (more)
    GO Terms (all 10)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA vcla-202 (1)    Ensembl 4069
    ncRNA vcla-002 (1)    Ensembl 491
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab6-vcl monoclonal IgG1 Mouse IHC Sigma-Aldrich
    7
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM vcla
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(uas:dnvcla-gfp) UAS GFPvcla Danio rerio 1 1
    MARKER RELATIONSHIPS
    vcla Contained in: [BAC] DKEY-188I15 (1) (order this), DKEY-231F24 (1) (order this), DKEY-252G6 (1) (order this)
    vcla Encodes: [EST] IMAGE:6902790 (1) (order this), zehn2160
    [cDNA] MGC:194417 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001128681 (1) 3540 bp
    Genomic GenBank:CR788251 (1) 150523 bp
    Select Tool
    Polypeptide UniProtKB:B3DI32 (1) 1131 aa
    Sequence Clusters UniGene:78221 (1)
    Sequence Information (all 31)
    ORTHOLOGY for vcla ( Chr: 13 )
    CITATIONS (34)