ZFIN ID: ZDB-GENE-050506-61
Gene Name: vinculin a
Gene Symbol: vcla
Previous Names: vcl, hm:zehn2160, im:6902790
Location: Chr: 13 Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 8 figures from 4 publications
Directly Submitted Expression Data: 4 figures (7 images) from Thisse et al., 2004 [IMAGE:6902790]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Adult (90d-730d, breeding adult)
  heart, lens, myotome, pectoral fin (all 8) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Mutagen Suppliers
la018484Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10865 Point Mutation ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14599 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents: MO1-vcla (1), MO2-vcla (1)
    PHENOTYPE
    Data: 3 figures from 2 publications
    Observed in: blood, blood circulation, cardiac muscle cell action potential, heart (all 8) expand
    DISEASE ASSOCIATED WITH vcla HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    dilated cardiomyopathy Cardiomyopathy, dilated, 1W 611407
    hypertrophic cardiomyopathy Cardiomyopathy, hypertrophic, 15 613255
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process heart contraction (more)
    Cellular Component actin cytoskeleton (more)
    Molecular Function actin filament binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000633 (1)
  • InterPro:IPR006077 (1)
  • PROSITE:PS00663 (1)
  • PROSITE:PS00664 (1)
  • Pfam:PF01044 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA vcla-001 (1) 4069
    ncRNA vcla-002 (1) 491
    GENE PRODUCT DESCRIPTION
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM vcla No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    vclaContained in: [BAC] DKEY-188I15 (1) (order this), DKEY-231F24 (1) (order this), DKEY-252G6 (1) (order this)
    vclaEncodes: [EST] IMAGE:6902790 (1) (order this), zehn2160
    [cDNA] MGC:194417 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001128681 (1) 3540bp
    Genomic GenBank:CR788251 (1) 150523bp
    Select Tool
    Polypeptide UniProtKB:B3DI32 (1) 1131aa
    Sequence Clusters UniGene:78221 (1)
    Sequence Information (all 30)
    OTHER vcla GENE PAGES
  • Gene:552980 (1)
  • VEGA:OTTDARG00000027752 (1)
  • Ensembl(GRCz10):ENSDARG00000044968 (1)
  • ORTHOLOGY for vcla (Chr: 13)
    Species Symbol Chromosome Accession # Evidence
    Human VCL 10
  • Gene:7414
  • OMIM:193065
  • HGNC:12665
  • Amino acid sequence comparison (3)
    Conserved genome location (synteny) (1)
    Mouse Vcl 14
  • MGI:98927
  • Gene:22330
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (22)