Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-050506-61
Gene Name: vinculin a
Gene Symbol: vcla
Previous Names: vcl, hm:zehn2160, im:6902790
Location: Chr: 13   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 7 figures from 3 publications
Directly Submitted Expression Data: 4 figures (7 images) from Thisse et al., 2004 [IMAGE:6902790]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Larval:Day 4 (96.0h-120.0h)
  lens, myotome, solid lens vesicle, somite border muscle tendon junction
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: la018484Tg, sa10865, sa14599
Knockdown reagents: MO1-vcla (1), MO2-vcla (1)
PHENOTYPE
Data: 2 figures from Vogel et al., 2009
Observed in: blood, blood circulation, heart, pericardium (all 7) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Cardiomyopathy, dilated, 1W 611407
Cardiomyopathy, familial hypertrophic, 15 613255
GENE ONTOLOGY
Ontology GO Term
Biological Process heart contraction (more)
Cellular Component actin cytoskeleton (more)
Molecular Function structural molecule activity (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000633 (1)
  • InterPro:IPR006077 (1)
  • InterPro:IPR017997 (1)
  • PROSITE:PS00663 (1)
  • PROSITE:PS00664 (1)
  • Pfam:PF01044 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA vcla-001 (1) 4069
    ncRNA vcla-002 (1) 491
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM vcla No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    vcla Contained in: [BAC] DKEY-188I15 (1), DKEY-231F24 (1), DKEY-252G6 (1)
    vcla Encodes: [EST] IMAGE:6902790 (1) (order this), zehn2160
    [cDNA] MGC:194417 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001128681 (1) 3540 bp
    Genomic GenBank:CR788251 (1) 150523 bp
    Select Tool
    Polypeptide UniProtKB:B3DI32 (1) 1131 aa
    Sequence Clusters UniGene:78221 (1)
    Sequence Information (all 30)
    OTHER vcla GENE PAGES
  • Gene:552980 (1)
  • VEGA:OTTDARG00000027752 (1)
  • Ensembl(Zv9):ENSDARG00000044968 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish vcla 13  
    Human VCL 10 (10q22.2)
  • OMIM:193065
  • Gene:7414
  • Mouse Vcl 14 ( 11.53 cM)
  • MGI:98927
  • Gene:22330
  • Orthology Details
    CITATIONS (19)