Gene

itga6a

ID
ZDB-GENE-050309-23
Name
integrin, alpha 6a
Symbol
itga6a Nomenclature History
Previous Names
  • itga6
  • fb80g02
  • im:6897425
  • si:dkey-32o22.1
  • wu:fb80g02
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Involved in skeletal muscle tissue development. Predicted to localize to integrin complex. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and junctional epidermolysis bullosa with pyloric atresia. Is expressed in several structures, including axial chorda mesoderm; hypodermis; retina; solid lens vesicle; and trunk. Orthologous to human ITGA6 (integrin subunit alpha 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Goody et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With itga6a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Epidermolysis bullosa, junctional 6, with pyloric atresia 619817
Associated With itga6a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
Domain IPR013649 Integrin alpha-2
Family IPR000413 Integrin alpha chain
Homologous_superfamily IPR028994 Integrin alpha, N-terminal
Homologous_superfamily IPR032695 Integrin domain superfamily
Repeat IPR013517 FG-GAP repeat
Repeat IPR013519 Integrin alpha beta-propellor
Domain Details Per Protein
Protein Length FG-GAP repeat Integrin alpha-2 Integrin alpha beta-propellor Integrin alpha chain Integrin alpha chain, C-terminal cytoplasmic region, conserved site Integrin alpha, N-terminal Integrin domain superfamily
UniProtKB:A8WHQ8 1092
UniProtKB:Q5CZS5 496
UniProtKB:A8WHQ7 1071
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-itga6a polyclonal Guinea pig
1
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations