Gene

th2

ID
ZDB-GENE-050201-1
Name
tyrosine hydroxylase 2
Symbol
th2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Exhibits tryptophan 5-monooxygenase activity. Involved in dopamine biosynthetic process and serotonin biosynthetic process. Predicted to localize to axon; cytoplasm; and perikaryon. Is expressed in head; kidney; liver; and nervous system.
Genome Resources
Note
None
Expression
All Expression Data
31 figures from 19 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
5 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With th2 Human Ortholog
No data available
Associated With th2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018301 Aromatic amino acid hydroxylase, iron/copper binding site
Domain IPR019774 Aromatic amino acid hydroxylase, C-terminal
Domain IPR041903 Tyrosine 3-monooxygenase, catalytic domain
Family IPR001273 Aromatic amino acid hydroxylase
Family IPR005962 Tyrosine 3-monooxygenase
Family IPR019773 Tyrosine 3-monooxygenase-like
Homologous_superfamily IPR036329 Aromatic amino acid monoxygenase, C-terminal domain superfamily
Homologous_superfamily IPR036951 Aromatic amino acid hydroxylase superfamily
Domain Details Per Protein
Protein Length Aromatic amino acid hydroxylase Aromatic amino acid hydroxylase, C-terminal Aromatic amino acid hydroxylase, iron/copper binding site Aromatic amino acid hydroxylase superfamily Aromatic amino acid monoxygenase, C-terminal domain superfamily Tyrosine 3-monooxygenase Tyrosine 3-monooxygenase, catalytic domain Tyrosine 3-monooxygenase-like
UniProtKB:Q6IVB6 471
UniProtKB:Q5RHI3 475
UniProtKB:Q1LWZ5 471
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
ab8-th Rabbit
  • WB
1
ab7-th IgY Chicken
  • IHC
  • WB
2
Ab4-th polyclonal Rabbit
  • IHC
  • WB
Millipore
28
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations