ZFIN ID: ZDB-GENE-041229-4
Gene Name: paired-like homeodomain 3
Gene Symbol: pitx3
Sequence Ontology ID : SO:0000704

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Previous Name: zgc:109716

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Location: Chr: 13 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 57 figures from 30 publications
Directly Submitted Expression Data: 6 figures (14 images) from Thisse et al., 2004 [MGC:109716]
Wild-type Stages, Structures: Cleavage:64-cell (2.0h-2.25h) to Adult (90d-730d, breeding adult)
  adenohypophyseal placode, adenohypophysis, anterior neural keel antero-lateral region, brain (all 41) expand
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3263 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa45 Point Mutation Unknown Splice Site ENU
    Targeting reagents: MO1-pitx3 (1), MO2-pitx3 (1), MO3-pitx3 (1), MO4-pitx3 (1)
    PHENOTYPE
    Data: 4 figures from 2 publications
    Observed in: amacrine cell, diencephalon dopaminergic neuron, diencephalon, dopaminergic neuron (all 12) expand
    DISEASE ASSOCIATED WITH pitx3 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    anterior segment mesenchymal dysgenesis Anterior segment mesenchymal dysgenesis 107250
    cataract 11 multiple types Cataract 11, multiple types 610623
    Cataract 11, syndromic 610623
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process adenohypophysis development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR003654 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR016233 (1)
  • InterPro:IPR017970 (1)
  • InterPro:IPR020479 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • PROSITE:PS50803 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF03826 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA pitx3-001 (1) 1865
    pitx3-002 (1) 884
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Ab1-pitx3 (1)
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM pitx3
    Tg(pitx3:EGFP)
    MARKER RELATIONSHIPS
    pitx3Contained in: [BAC] DKEY-183C23 (1) (order this), DKEY-196H17 (1) (order this)
    pitx3Encodes: [cDNA] MGC:109716 (1) (order this), MGC:192409 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_205675 (1) 1882bp
    Genomic GenBank:CR626878 (1) 201749bp Blast at MegaBLAST
    Polypeptide UniProtKB:B2GRZ8 (1) 293aa
    Sequence Clusters UniGene:89375 (1)
    Sequence Information (all 26)
    OTHER pitx3 GENE PAGES
  • Alliance (1)
  • Gene:402974 (1)
  • VEGA:OTTDARG00000020663 (1)
  • Ensembl(GRCz10):ENSDARG00000070069 (1)
  • ORTHOLOGY for pitx3 (Chr: 13)
    CITATIONS (62)