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ZIRC
ZFIN ID: ZDB-GENE-041114-7
Gene Name: OPA1 mitochondrial dynamin like GTPase
Gene Symbol: opa1
Sequence Ontology ID : SO:0001217

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Previous Names: fk62d06, wu:fb77a10, wu:fk62d06, zgc:92092

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(Including Attributions)
Location: Chr: 6 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have GTPase activity; microtubule binding activity; and phospholipid binding activity. Involved in chordate embryonic development; mitochondrion morphogenesis; and ventricular cardiac  ...
GENE EXPRESSION
All Expression Data: 9 figures from 7 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7155623]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7157256]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ws1357Tg Transgenic Insertion Intron 27 Unknown DNA
  • European Zebrafish Resource Center (EZRC) (order this)
  • Targeting reagents:
    DISEASE ASSOCIATED WITH opa1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    dominant optic atrophy plus syndrome Optic atrophy plus syndrome 125250
    mitochondrial DNA depletion syndrome 14 ?Mitochondrial DNA depletion syndrome 14 (encephalocardiomyopathic type) 616896
    optic atrophy 1 Optic atrophy 1 165500
    Behr syndrome 210000
    {Glaucoma, normal tension, susceptibility to} 606657
    DISEASE ASSOCIATED WITH opa1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chordate embryonic development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function cardiolipin binding (more)
    GO Terms (all 25)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA opa1-201 (1) 4305
    opa1-202 (1) 1463
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM opa1 No data available
    MARKER RELATIONSHIPS
    opa1 Contained in: [BAC] CH211-196H19 (1) (order this), DKEY-18A23 (1) (order this)
    opa1 Encodes: [EST] fb77a10, fk62d06 (1), IMAGE:7155623 (1) (order this), IMAGE:7157256 (1) (order this)
    [cDNA] MGC:92092 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001007298 (1) 4296 bp
    Genomic GenBank:BX004839 (1) 223000 bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0R4IJ30 (1) 1034 aa
    Sequence Clusters UniGene:37656 (1)
    Sequence Information (all 35)
    ORTHOLOGY for opa1 ( Chr: 6 )
    CITATIONS (36)