Gene

opa1

ID
ZDB-GENE-041114-7
Name
OPA1 mitochondrial dynamin like GTPase
Symbol
opa1 Nomenclature History
Previous Names
  • fk62d06
  • wu:fb77a10
  • wu:fk62d06
  • zgc:92092
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to enable GTPase activity; microtubule binding activity; and phospholipid binding activity. Acts upstream of or within chordate embryonic development; mitochondrion morphogenesis; and ventricular cardiac muscle cell development. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be active in microtubule and mitochondrial membrane. Is expressed in retina. Human ortholog(s) of this gene implicated in Behr syndrome; dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; optic atrophy; and optic atrophy 1. Orthologous to human OPA1 (OPA1 mitochondrial dynamin like GTPase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
14 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With opa1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Behr syndrome Alliance Behr syndrome 210000
dominant optic atrophy plus syndrome Alliance Optic atrophy plus syndrome 125250
mitochondrial DNA depletion syndrome 14 Alliance ?Mitochondrial DNA depletion syndrome 14 (encephalocardiomyopathic type) 616896
optic atrophy 1 Alliance Optic atrophy 1 165500
{Glaucoma, normal tension, susceptibility to} 606657
Associated With opa1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001401 Dynamin, GTPase domain
Domain IPR030381 Dynamin-type guanine nucleotide-binding (G) domain
Domain IPR045063 Dynamin, N-terminal
Domain IPR045817 Dynamin-like GTPase OPA1, C-terminal
Family IPR022812 Dynamin
Family IPR033047 Dynamin-like 120kDa protein, mitochondrial
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length Dynamin Dynamin, GTPase domain Dynamin-like 120kDa protein, mitochondrial Dynamin-like GTPase OPA1, C-terminal Dynamin, N-terminal Dynamin-type guanine nucleotide-binding (G) domain P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A0A0R4IJ30 1034
UniProtKB:A0A0R4ILJ7 454
UniProtKB:A0A2R8Q487 995
UniProtKB:A0A2R8Q0F5 1018
UniProtKB:Q5U3A7 966
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab2-opa1 monoclonal IgG1 Mouse
  • IHC
BD Biosciences
2
Ab3-opa1 monoclonal IgG1 Mouse
  • WB
BD Biosciences
3
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations